Senolytics: charting a new course or enhancing existing anti-tumor therapies?

M. Roser, H. Ritchie, Cancer. Published online at OurWorldInData.org (2019). Retrieved December 2, 2023, from: https://ourworldindata.org/cancer

S. Chakraborty, T. Rahman, The difficulties in cancer treatment. Ecancermedicalscience. 6, ed16 (2012). https://doi.org/10.3332/ecancer.2012.ed16

Article  PubMed  PubMed Central  Google Scholar 

World Demographics 2023 (Population, Age, Sex, Trends) - Worldometer. (b. d.). Worldometer - real time world statistics. https://www.worldometers.info/demographics/world-demographics/. Accessed 2 Dec 2023

C.A. Schmitt, Cellular senescence and cancer treatment. Biochim. Biophys. Acta (BBA) - reviews on Cancer 1775(1), 5–20 (2007). https://doi.org/10.1016/j.bbcan.2006.08.005

L. Wang, L. Lankhorst, R. Bernards, Exploiting senescence for the treatment of cancer. Nat. Rev. Cancer (2022). https://doi.org/10.1038/s41568-022-00450-9

Article  PubMed  Google Scholar 

T. Saleh, S. Bloukh, V.J. Carpenter, E. Alwohoush, J. Bakeer, S. Darwish, B. Azab, D.A. Gewirtz, Therapy-induced senescence: an old friend becomes the enemy. Cancers 12(4), 822 (2020). https://doi.org/10.3390/cancers12040822

C.J. Sieben, I. Sturmlechner, van de B. Sluis, van J.M. Deursen, Two-step senescence-focused Cancer therapies. Trends Cell Biol. 28(9), 723–737 (2018). https://doi.org/10.1016/j.tcb.2018.04.006

Article  CAS  PubMed  PubMed Central  Google Scholar 

C. Nardella, J.G. Clohessy, A. Alimonti, P.P. Pandolfi, Pro-senescence therapy for cancer treatment. Nat. Rev. Cancer 11(7), 503–511 (2011). https://doi.org/10.1038/nrc3057

Article  CAS  PubMed  Google Scholar 

E. Sikora, A. Bielak-Zmijewska, G. Mosieniak, Targeting normal and cancer senescent cells as a strategy of senotherapy. Ageing Res. Rev. 55, 100941 (2019). https://doi.org/10.1016/j.arr.2019.100941

Article  CAS  PubMed  Google Scholar 

L. Hayflick, The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37(3), 614–636 (1965). https://doi.org/10.1016/0014-4827(65)90211-9

Article  CAS  PubMed  Google Scholar 

T. Kuilman, C. Michaloglou, W.J. Mooi, D.S. Peeper, The essence of senescence. Genes Dev. 24(22), 2463–2479 (2010). https://doi.org/10.1101/gad.1971610

Article  CAS  PubMed  PubMed Central  Google Scholar 

J.M. van Deursen, The role of senescent cells in ageing. Nature 509(7501), 439–446 (2014). https://doi.org/10.1038/nature13193

Article  CAS  PubMed  PubMed Central  Google Scholar 

M. Demaria, N. Ohtani, S.A. Youssef, F. Rodier, W. Toussaint, J.R. Mitchell, R.-M. Laberge, J. Vijg, Van H. Steeg, M.E.T. Dollé, J.H.J. Hoeijmakers, de A. Bruin, E. Hara, J. Campisi, An essential role for senescent cells in Optimal Wound Healing through Secretion of PDGF-AA. Dev. Cell 31(6), 722–733 (2014). https://doi.org/10.1016/j.devcel.2014.11.012

Article  CAS  PubMed  PubMed Central  Google Scholar 

D. Muñoz-Espín, M. Cañamero, A. Maraver, G. Gómez-López, J. Contreras, S. Murillo-Cuesta, A. Rodríguez-Baeza, I. Varela-Nieto, J. Ruberte, M. Collado, M. Serrano, Programmed cell senescence during mammalian Embryonic Development. Cell 155(5), 1104–1118 (2013). https://doi.org/10.1016/j.cell.2013.10.019

Article  CAS  PubMed  Google Scholar 

J. Campisi, Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 11(11) (2001). https://doi.org/10.1016/s0962-8924(01)02151-1. 27—S31

N. Herranz, J. Gil, Mechanisms and functions of cellular senescence. J. Clin. Invest. 128(4), 1238–1246 (2018). https://doi.org/10.1172/jci95148

Article  PubMed  PubMed Central  Google Scholar 

J. Beck, I. Horikawa, C. Harris, Cellular senescence: mechanisms, morphology, and mouse models. Vet. Pathol. 57(6), 747–757 (2020). https://doi.org/10.1177/030098582094384

Article  CAS  PubMed  Google Scholar 

E. Sikora, G. Mosieniak, M. Alicja Sliwinska, Morphological and functional characteristic of senescent cancer cells. Curr. Drug Targets 17(4), 377–387 (2016)

Article  CAS  PubMed  Google Scholar 

C. Druelle, C. Drullion, J. Desle, N. Martini, L. Saas, J. Cormenier, N. Malaquin, L. Huot, C. Slomianny, F. Bouali, O. Pluquet, ATF6 alpha regulates morphological changes associated with senescence in human fibroblasts. Oncotarget 7(42), 67699–67715 (2016). https://doi.org/10.18632/oncotarget.11505

R. Kumari, P. Jat, Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype. Front. cell. Dev. Biology. 9, 645593 (2021). https://doi.org/10.3389/fcell.2021.645593

Article  Google Scholar 

A. Hernandez-Segura, J. Nehme, M. Demaria, Hallmarks of cellular senescence. Trends Cell Biol. 28(6), 436–453 (2018). https://doi.org/10.1016/j.tcb.2018.02.001

Article  CAS  PubMed  Google Scholar 

S.J. Ryu, Y.S. Oh, S.C. Park, Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts. Cell. Death Differ. 14(5), 1020–1028 (2007). https://doi.org/10.1038/sj.cdd.4402091

Article  CAS  PubMed  Google Scholar 

M. Althubiti, L. Lezina, S. Carrera, R. Jukes-Jones, S.M. Giblett, A. Antonov, N. Barlev, G.S. Saldanha, C.A. Pritchard, K. Cain, S. Macip, Characterization of novel markers of senescence and their prognostic potential in cancer. Cell Death Dis. 5(11), e1528–e1528 (2014). https://doi.org/10.1038/cddis.2014.489

K.M. Kim, J.H. Noh, M. Bodogai, J.L. Martindale, X. Yang, F.E. Indig, S.K. Basu, K. Ohnuma, C. Morimoto, P.F. Johnson, M. Gorospe, Identification of senescent cell surface targetable protein DPP4. Genes Dev. 31(15), 1529–1534 (2017). https://doi.org/10.1101/gad.302570.117

V.I. Korolchuk, S. Miwa, B. Carroll, Von T. Zglinicki, Mitochondria in cell senescence: is mitophagy the weakest link? EBioMedicine. 21, 7–13 (2017). https://doi.org/10.1016/j.ebiom.2017.03.020

Article  PubMed  PubMed Central  Google Scholar 

S. Cho, E.S. Hwang, Status of mTOR activity may phenotypically differentiate senescence and quiescence. Mol. Cells. 33, 597–604 (2012). https://doi.org/10.1007/s10059-012-0042-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

G.P. Dimri, X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E.E. Medrano, M. Linskens, I. Rubelj, O. Pereira-Smith, A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. 92(20), 9363–9367 (1995). https://doi.org/10.1073/pnas.92.20.9363

B.M. Hall, V. Balan, A.S. Gleiberman, E. Strom, P. Krasnov, L.P. Virtuoso, E. Rydkina, S. Vujcic, K. Balan, I.I. Gitlin, K.I. Leonova, C.R. Consiglio, S.O. Gollnick, O.B. Chernova, A.V. Gudkov, p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli. Aging. 9(8), 1867–1884 (2017). https://doi.org/10.18632/aging.101268

Article  CAS  PubMed  PubMed Central  Google Scholar 

M. Sadaie, R. Salama, T. Carroll, K. Tomimatsu, T. Chandra, A.R. Young, M. Narita, P.A. Pérez-Mancera, D.C. Bennett, H. Chong, M. Narita, Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev. 27(16), 1800–1808 (2013). https://doi.org/10.1101/gad.217281.113

K.M. Aird, R. Zhang, Detection of senescence-associated heterochromatin foci (SAHF). Cell. Senescence: Methods Protocols. 185–196 (2013). https://doi.org/10.1007/978-1-62703-239-1_12

M. Takasugi, Y. Yoshida, E. Hara, N. Ohtani, The role of cellular senescence and SASP in tumour microenvironment. FEBS J. 290(5), 1348–1361 (2023). https://doi.org/10.1111/febs.16381

Article  CAS  PubMed  Google Scholar 

T. Kuilman, D.S. Peeper, Senescence-messaging secretome: SMS-ing cellular stress. Nat. Rev. Cancer. 9(2), 81–94 (2009). https://doi.org/10.1038/nrc2560

Article  CAS  PubMed  Google Scholar 

J.-P. Coppé, C.K. Patil, F. Rodier, Y. Sun, D.P. Muñoz, J. Goldstein, P.S. Nelson, P.-Y. Desprez, J. Campisi, Senescence-Associated secretory phenotypes reveal cell-nonautonomous functions of Oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 6(12) (2008). Artykuł e301. https://doi.org/10.1371/journal.pbio.0060301

J.-P. Coppé, P.-Y. Desprez, A. Krtolica, J. Campisi, The Senescence-Associated Secretory phenotype: the Dark side of Tumor suppression. Annu. Rev. Pathol. 5(1), 99–118 (2010). https://doi.org/10.1146/annurev-pathol-121808-102144

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. Lujambio, L. Akkari, J. Simon, D. Grace, D.F. Tschaharganeh, J.E. Bolden, Z. Zhao, V. Thapar, J.A. Joyce, V. Krizhanovsky, S.W. Lowe, Non-cell-autonomous tumor suppression by p53. Cell. 153(2), 449–460 (2013). https://doi.org/10.1016/j.cell.2013.03.020

Article  CAS  PubMed  PubMed Central  Google Scholar 

S. Yoshimoto, T.M. Loo, K. Atarashi, H. Kanda, S. Sato, S. Oyadomari, Y. Iwakura, K. Oshima, H. Morita, M. Hattori, K. Honda, Y. Ishikawa, E. Hara, N. Ohtani, Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature. 499(7456), 97–101 (2013). https://doi.org/10.1038/nature12347

Article  CAS  PubMed 

Comments (0)

No login
gif