Prostatic amyloidosis: pathological features of an underdiagnosed condition

King LS (1948) Atypical amyloid disease, with observations on a new silver stain for amyloid. Am J Pathol 24(5):1095–1115

PubMed  PubMed Central  Google Scholar 

Dahlin DC (1949) Primary amyloidosis, with report of six cases. Am J Pathol 25(1):105–123

PubMed  PubMed Central  Google Scholar 

Mcdonald JH, Heckel NJ (1956) Primary amyloidosis of the lower genitourinary tract. J Urol 75(1):122–132. https://doi.org/10.1016/S0022-5347(17)66786-7

Article  PubMed  Google Scholar 

Tripathi VN, Desautels RE (1969) Primary amyloidosis of the urogenital system: a study of 16 cases and brief review. J Urol 102(1):96–101. https://doi.org/10.1016/s0022-5347(17)62084-6

Article  PubMed  Google Scholar 

Lupovitch A (1972) The prostate and amyloidosis. J Urol 108(2):301–302. https://doi.org/10.1016/s0022-5347(17)60719-5

Article  PubMed  Google Scholar 

Wilson SK, Buchanan RD, Stone WJ, Rhamy RK (1973) Amyloid deposition in the prostate. J Urol 110(3):322–323. https://doi.org/10.1016/s0022-5347(17)60202-7

Article  PubMed  Google Scholar 

Carris CK, McLaughlin AP 3rd, Gittes RF (1976) Amyloidosis of the lower genitourinary tract. J Urol 115(4):423–426. https://doi.org/10.1016/s0022-5347(17)59226-5

Article  PubMed  Google Scholar 

Mazanec K, McClure J, Bartley CJ, Newbould MJ, Ackrill P (1992) Systemic amyloidosis of beta 2 microglobulin type. J Clin Pathol 459(9):832–833. https://doi.org/10.1136/jcp.45.9.832

Article  Google Scholar 

Mattocks S, Molyneux AJ, Doyle P (1993) Localised amyloidosis of the prostate. Br J Urol 72(5Pt1):655–656. https://doi.org/10.1111/j.1464-410x.1993.tb16227.x

Article  PubMed  Google Scholar 

Mark IR, Goodlad J, Lloyd-Davies RW (1995) Localized amyloidosis of the genito-urinary tract. J R Soc Med 88(6):320–324

PubMed  PubMed Central  Google Scholar 

Esslimani M, Serre I, Granier M, Robert M, Baldet P, Costes V (1999) Urogenital amyloidosis: clinico-pathological study of 8 cases. Ann Pathol 19(6):487–491

PubMed  Google Scholar 

Lawrentschuk N, Pan D, Stillwell R, Bolton DM (2004) Implications of amyloidosis on prostatic biopsy. Int J Urol 11(10):925–927. https://doi.org/10.1111/j.1442-2042.2004.00921.x

Article  PubMed  Google Scholar 

Singh SK, Wadhwa P, Nada R, Mohan VC, Singh P, Jha V (2005) Localized primary amyloidosis of the prostate, bladder and ureters. Int Urol Nephrol 37(3):495–497. https://doi.org/10.1007/s11255-005-2088-x

Article  PubMed  Google Scholar 

Snyder ME, Haidar GR, Spencer B, Maurer MS (2011) Transthyretin cardiac amyloidosis diagnosed by analyzing a prostatic tissue sample: a case report. J Am Geriatr Soc 59(9):1745–1747. https://doi.org/10.1111/j.1532-5415.2011.03549.x

Article  PubMed  Google Scholar 

Ogawa Y, Nakagawa M, Ikeda S-I (2013) Prostate amyloid tumor is a clue leading to the diagnosis of systemic AL amyloidosis. Amyloid 20(3):193–194. https://doi.org/10.3109/13506129.2013.797390

Article  PubMed  Google Scholar 

Nevo A, Muchtar E, Stern KL et al (2020) The clinical implication of incidental prostatic amyloidosis. Urology 145:253–257. https://doi.org/10.1016/j.urology.2020.08.053

Article  PubMed  Google Scholar 

Ledesma FL, Castelli JB (2021) Autopsy findings in a patient with primary systemic AL (kappa light chain) amyloidosis. Autops Case Rep 11:e2021273. https://doi.org/10.4322/acr.2021.273

Article  PubMed  PubMed Central  Google Scholar 

Maeda K, Kubota Y, Kitagawa S, Ueda M, Ando Y, Ito Y (2021) The prostate as a good candidate organ for proving amyloid deposition in non-endemic late onset hereditary transthyretin amyloidosis: Report of two cases. J Neurol Sci 424:117418. https://doi.org/10.1016/j.jns.2021.117418

Article  PubMed  Google Scholar 

Dasari S, Dispenzieri A, Mansour S et al (2021) Non-cardiac biopsy sites with high frequency of transthyretin amyloidosis. ESC Heart Fail 8(1):750–755. https://doi.org/10.1002/ehf2.13130

Article  PubMed  Google Scholar 

Nemov I, Hougen HY, Iakymenko OA, Jorda M, Gonzalgo ML, Kryvenko ON (2022) Localized amyloidosis of the seminal tract is not associated with subsequent development of systemic amyloidosis. Urology 164:46–49. https://doi.org/10.1016/j.urology.2021.12.008

Article  PubMed  Google Scholar 

Nguyen J, Alhamar M, Williamson S (2022) Amyloid is underdiagnosed in prostate specimens and may be clinically significant (abs598). In “Genitourinary Pathology (including renal tumors).” Mod Pathol 35(suppl 2):642–643

Google Scholar 

Sibley RR, Ellison B, Siegert JJ, Gorder MAV (2022) Isolated prostate amyloidosis; a case report. Urol Case Rep 45:102229. https://doi.org/10.1016/j.eucr.2022.102229

Article  PubMed  PubMed Central  Google Scholar 

Foix MP, Calvo DF, Mundó CI et al (2022) Clinical relevance of amyloid in prostate samples: a report on 40 patients. Histopathology 81(3):363–370. https://doi.org/10.1111/his.14717

Article  PubMed  Google Scholar 

Gilani SI, Dasari S, Tekin B et al (2023) Identification of amyloidosis of the urinary tract and prostate: opportunities for early diagnosis & intervention in systemic disease. Hum Pathol 142:62–67. https://doi.org/10.1016/j.humpath.2023.11.001

Article  PubMed  Google Scholar 

Yang Z, Laird A, Monaghan A, Seywright M, Ahmad I, Leung HY (2013) Incidental seminal vesicle amyloidosis observed in diagnostic prostate biopsies–are routine investigations for systemic amyloidosis warranted? Asian J Androl 15(1):149–151. https://doi.org/10.1038/aja.2012.125

Article  PubMed  Google Scholar 

Collins K, Al-Obaidy K, Warmke L, Cary C, Chen S (2021) Localized amyloidosis of the prostatic urethra mimicking urothelial carcinoma. Am J Clin Exp Urol 9(5):403–412

PubMed  PubMed Central  Google Scholar 

Coelho T, Dispenzieri A, Grogan M et al (2023) Patients with transthyretin amyloidosis enrolled in THAOS between 2018 and 2021 continue to experience substantial diagnostic delay. Amyloid 30(4):445–448. https://doi.org/10.1080/13506129.2023.2229484

Article  PubMed  Google Scholar 

Riefolo M, Conti M, Longhi S, Fabbrizio B, Leone O (2022) Amyloidosis: what does pathology offer? The evolving field of tissue biopsy. Front Cardiovasc Med 9:1081098. https://doi.org/10.3389/fcvm.2022.1081098

Article  PubMed  PubMed Central  Google Scholar 

Manso MC, Marques DP, Rocha SL, Rodeia SC, Domingos R (2017) Senile systemic amyloidosis an underdiagnosed disease. Eur J Case Rep Intern Med 4(9):000725. https://doi.org/10.12890/2017_000725

Article  PubMed  PubMed Central  Google Scholar 

Noborn F, Thomsen C, Vorontsov E et al (2023) Subtyping of cardiac amyloidosis by mass spectrometry-based proteomics of endomyocardial biopsies. Amyloid 30(1):96–108. https://doi.org/10.1080/13506129.2022.2127088

Article  PubMed  Google Scholar 

Garcia-Pavia P, Rapezzi C, Adler Y et al (2021) Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases. Eur Heart J 42(16):1554–1568. https://doi.org/10.1093/eurheartj/ehab072

Article  PubMed  PubMed Central  Google Scholar 

Terentes-Printzios D, Antonopoulos AS, Omer M et al (2023) Cardiac amyloidosis remains significantly underdiagnosed in patients undergoing TAVR: analysis of National Inpatient Sample. Amyloid 30(2):246–247. https://doi.org/10.1080/13506129.2022.2159369

Article  PubMed  Google Scholar 

Porcari A, Bussani R, Merlo M et al (2021) Incidence and characterization of concealed cardiac amyloidosis among unselected elderly patients undergoing post-mortem examination. Front Cardiovasc Med 8:749523. https://doi.org/10.3389/fcvm.2021.749523

Article  PubMed  PubMed Central 

Comments (0)

No login
gif