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L.C. Nguyen, D.T.M. Luu, H.T.N. Doan, N.M. Nguyen, H.T.T. Nguyen, T.T. Pham, N.B. Pham, T.P. Le, T.T. Nguyen, H.V. Nguyen
Gastroenterology and Hepatology Center, Bach Mai Hospital, Giai Phong Road, Ha Noi, Vietnam. nguyenconglong@bachmai.edu.vn
OBJECTIVE: Hepatocellular carcinoma (HCC) is a significant cause of morbidity and mortality worldwide. This study aims to comprehensively evaluate the prognostic factors influencing survival in patients diagnosed with HCC.
PATIENTS AND METHODS: This is a cross-sectional study aimed at identifying prognostic factors in HCC using Cox regression and Kaplan-Meier analysis. A cohort of 364 predominantly male HCC patients with a mean age of 61.6 ± 10.9 years was analyzed.
RESULTS: Significant risk factors for mortality included HCV infection, alcoholism, elevated alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA) II levels, and a Child-Pugh score of 8. HCV-positive patients had a hazard ratio (HR) of 2.25. Average survival time was 32.99 ± 31.64 months, with 1, 2, and 3-year survival rates of 73.6%, 44.5%, and 31.3%, respectively. Patients with PIVKA-II levels ≤ 125 mAU/mL had a significantly higher 50% chance of surviving 42 months. Patients with the Barcelona clinic liver cancer (BCLC) stage B1 displayed a higher survival rate, except at the 24-month time point, with BCLC A and B1 groups showing survival rates exceeding 80% in the first year.
CONCLUSIONS: The findings provide valuable insights into the prognostic implications and risk stratification in HCC, facilitating personalized treatment decisions and potentially improving patient outcomes.
L.C. Nguyen, D.T.M. Luu, H.T.N. Doan, N.M. Nguyen, H.T.T. Nguyen, T.T. Pham, N.B. Pham, T.P. Le, T.T. Nguyen, H.V. Nguyen
Prognostic factor and risk stratification in hepatocellular carcinoma: insights from Cox regression and Kaplan-Meier analysis in a male-dominated cohort
Eur Rev Med Pharmacol Sci
Year: 2024
Vol. 28 - N. 24
Pages: 4701-4711
DOI: 10.26355/eurrev_202412_37004
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