Abdulhafiz F, Mohammed A, Reduan MFH, Kari ZA, Wei LS, Goh KW (2022) Plant cell culture technologies: A promising alternatives to produce high-value secondary metabolites. Arab J Chem 15:104161. https://doi.org/10.1016/J.ARABJC.2022.104161

Article  Google Scholar 

Agostini E, Talano MA, González PS, Oller ALW, Medina MI (2013) Application of hairy roots for phytoremediation: what makes them an interesting tool for this purpose? Appl Microbiol Biot 97:1017–1030. https://doi.org/10.1007/S00253-012-4658-Z

Article  Google Scholar 

Agrawal S, Rami E (2022) A review: Agrobacterium-mediated gene transformation to increase plant productivity. J Phytopharmacol 11:111–117. https://doi.org/10.31254/PHYTO.2022.11211

Article  Google Scholar 

Ahadi H, Shokrpour M, Fatahi R, Naghavi MR, Mirjalili MH (2023) Essential oil, flavonoids and anthocyanins profiling of some Iranian damask rose (Rosa damascena Mill.) genotypes. Ind Crops Prod 205:117579. https://doi.org/10.1016/J.INDCROP.2023.117579

Article  Google Scholar 

Ahlawat S, Saxena P, Alam P, Wajid S, Abdin MZ (2014) Modulation of artemisinin biosynthesis by elicitors, inhibitor, and precursor in hairy root cultures of Artemisia annua L. J Plant Interact 9:811–824. https://doi.org/10.1080/17429145.2014.949885

Article  Google Scholar 

Andersen DC, Krummen L (2002) Recombinant protein expression for therapeutic applications. Curr Opin Biot 13:117–123. https://doi.org/10.1016/S0958-1669(02)00300-2

Article  Google Scholar 

Ansari WA, Chandanshive SU, Bhatt V, Nadaf AB, Vats S, Katara JL, Sonah H, Deshmukh R (2020) Genome editing in cereals: approaches, applications and challenges. Int JMol Sci 21:4040. https://doi.org/10.3390/IJMS21114040

Article  Google Scholar 

Aragão MM, Alvarez MA, Caiafa L, Santos MO (2023) Nicotiana hairy roots for recombinant protein expression, where to start? A systematic review. Mol Biol Rep 50:4587–4604. https://doi.org/10.1007/S11033-023-08360-1/METRICS

Article  PubMed  Google Scholar 

Arcalis E, Marcel S, Altmann F, Kolarich D, Drakakaki G, Fischer R, Christou P, Stoger E (2004) Unexpected deposition patterns of recombinant proteins in post-endoplasmic reticulum compartments of wheat endosperm. Plant Physiol 136:3457–3466. https://doi.org/10.1104/PP.104.050153

Article  PubMed  PubMed Central  Google Scholar 

Arnau J, Lauritzen C, Petersen GE, Pedersen J (2006) Current strategies for the use of affinity tags and tag removal for the purification of recombinant proteins. Protein Expr Purif 48:1–13. https://doi.org/10.1016/J.PEP.2005.12.002

Article  PubMed  Google Scholar 

Asmani F, Khavari-Nejad RA, Salmanian AH, Amani J (2022) Immunological evaluation of recombinant chimeric construct from enterotoxigenic E. coli expressed in hairy roots. Mol Immunol 147:81–89. https://doi.org/10.1016/J.MOLIMM.2022.02.010

Article  PubMed  Google Scholar 

Assenberg R, Wan PT, Geisse S, Mayr LM (2013) Advances in recombinant protein expression for use in pharmaceutical research. Curr Opin Struct Biol 23:393–402. https://doi.org/10.1016/J.SBI.2013.03.008

Article  PubMed  Google Scholar 

Ayan A, Meriç S, Gümüş T, Atak Ç (2022) Next generation of transgenic plants: from farming to pharming. In: Genetically modified plants and beyond, vol 49. IntechOpen, London.

Baghalian K, Naghavi MR, Ziai SA, Badi HN (2006) Post-planting evaluation of morphological characters and allicin content in Iranian garlic (Allium sativum L.) ecotypes. Sci Hortic 107:405–410. https://doi.org/10.1016/J.SCIENTA.2005.11.008

Article  Google Scholar 

Bais HP, Loyola-Vargas VM, Flores HE, Vivanco JM (2001) Root-specific metabolism: the biology and biochemistry of underground organs. In Vitro Cell Dev Biol - Plant 37:730–741. https://doi.org/10.1007/S11627-001-0122-Y/METRICS

Article  Google Scholar 

Baldi L, Hacker DL, Adam M, Wurm FM (2007) Recombinant protein production by large-scale transient gene expression in mammalian cells: State of the art and future perspectives. Biotechnol Lett 29:677–684. https://doi.org/10.1007/S10529-006-9297-Y/TABLES/1

Article  PubMed  Google Scholar 

Bapat VA, Kavi Kishor PB, Jalaja N, Jain SM, Penna S (2023) Plant cell cultures: bio factories for the production of bioactive compounds. Agronomy 13:858. https://doi.org/10.3390/AGRONOMY13030858

Article  Google Scholar 

Bertucci C, Pistolozzi M, De Simone A (2011) Structural characterization of recombinant therapeutic proteins by circular dichroism. Curr Pharm Biotechnol 12:1508–1516. https://doi.org/10.2174/138920111798357276

Article  PubMed  Google Scholar 

Beygmoradi A, Homaei A, Hemmati R, Fernandes P (2023) Recombinant protein expression: challenges in production and folding related matters. Int J Biol Macromol 233:123407. https://doi.org/10.1016/J.IJBIOMAC.2023.123407

Article  PubMed  Google Scholar 

Bhat KA, Tariq L, Ayaz A, Manzoor M, Zargar SM, Shah AA (2022) Molecular farming: sustainable manufacturing of vaccines, antibodies, and other therapeutic substances. In: Metabolic Engineering: Concepts and Applications. In: Williams HS (eds) Metabolic Engineering, vol 1. Springer, New York, pp 239–261. https://doi.org/10.1007/978-981-16-7262-0_10

Bouchez D, Tourneur J (1991) Organization of the agropine synthesis region of the T-DNA of the Ri plasmid from Agrobacterium rhizogenes. Plasmid 25:27–39. https://doi.org/10.1016/0147-619X(91)90004-G

Article  PubMed  Google Scholar 

Brondyk WH (2009) Selecting an appropriate method for expressing a recombinant protein. In: Methods Enzymol, vol 463, Elsevier, pp 131–147. https://doi.org/10.1016/S0076-6879(09)63011-1

Burnett MJB, Burnett AC (2020) Therapeutic recombinant protein production in plants: Challenges and opportunities. Plants People Planet 2:121–132. https://doi.org/10.1002/PPP3.10073

Article  Google Scholar 

Cardon F, Pallisse R, Bardor M, Caron A, Vanier J, Ele Ekouna JP, Lerouge P, Boitel-Conti M, Guillet M (2019) Brassica rapa hairy root-based expression system leads to the production of highly homogenous and reproducible profiles of recombinant human alpha-L-iduronidase. Plant Biotechnol J 17:505–516. https://doi.org/10.1111/PBI.12994

Article  PubMed  Google Scholar 

Chaghakaboodi Z, Kahrizi D, Nasiri J (2023) Callus and hairy root induction in the medicinal plant of Withania coagulans (Stocks) Dunal. Intl J Med Plants By-Prod. https://doi.org/10.22034/JMPB.2023.362344.1563

Chahardoli M, Fazeli A, Ghabooli M (2018) Recombinant production of bovine lactoferrin-derived antimicrobial peptide in tobacco hairy roots expression system. Plant Physiol Biochem 123:414–421. https://doi.org/10.1016/J.PLAPHY.2017.12.037

Article  PubMed  Google Scholar 

Chandra S (2012) Natural plant genetic engineer Agrobacterium rhizogenes: role of T-DNA in plant secondary metabolism. Biotechnol Lett 34:407–415. https://doi.org/10.1007/S10529-011-0785-3/TABLES/1

Article  PubMed  Google Scholar 

Chandra S, Chandra R (2011) Engineering secondary metabolite production in hairy roots. Phytochem Rev 10:371–395. https://doi.org/10.1007/S11101-011-9210-8

Article  Google Scholar 

Chandran H, Meena M, Barupal T, Sharma K (2020) Plant tissue culture as a perpetual source for production of industrially important bioactive compounds. Biotechnol Rep 26:e00450. https://doi.org/10.1016/J.BTRE.2020.E00450

Article  Google Scholar 

Chen MH, Huang LF, Li HM, Chen YR, Yu SM (2004) Signal peptide-dependent targeting of a rice α-Amylase and cargo proteins to plastids and extracellular compartments of plant cells. Plant Physiol 135:1367–1377. https://doi.org/10.1104/PP.104.042184

Article  PubMed  PubMed Central  Google Scholar 

Chen Q, Lai H (2015) Gene delivery into plant cells for recombinant protein production. Biomed Res Int 2015:10. https://doi.org/10.1155/2015/932161

Article  Google Scholar 

Condori J, Nopo-Olazabal C, Medrano G, Medina-Bolivar F (2011) Selection of reference genes for qPCR in hairy root cultures of peanut. BMC Res Notes 4:1–20. https://doi.org/10.1186/1756-0500-4-392/FIGURES/10

Article  Google Scholar 

Corrado G, Karali M (2009) Inducible gene expression systems and plant biotechnology. Biotechnol Adv 27:733–743. https://doi.org/10.1016/J.BIOTECHADV.2009.05.006

Article  PubMed  Google Scholar 

Cutt JR, Harpster MH, Dixon DC, Carr JP, Dunsmuir P, Klessig DF (1989) Disease response to tobacco mosaic virus in transgenic tobacco plants that constitutively express the pathogenesis-related PR1b gene. Virology 173:89–97. https://doi.org/10.1016/0042-6822(89)90224-9

Article  PubMed  Google Scholar 

Dehdashti SM, Acharjee S, Nomani A, Deka M (2020) Production of pharmaceutical active recombinant globular adiponectin as a secretory protein in Withania somnifera hairy root culture. J Biotechnol 323:302–312. https://doi.org/10.1016/J.JBIOTEC.2020.07.012

Article  PubMed  Google Scholar 

Deng C, Hao X, Shi M, Fu R, Wang Y, Zhang Y, Zhou W, Feng Y, Makunga NP, Kai G (2019) Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots. Plant Sci 284:1–8. https://doi.org/10.1016/J.PLANTSCI.2019.03.007

Article  PubMed  Google Scholar 

Deng H, Li Q, Cao R, Ren Y, Wang G, Guo H, Bu S, Liu J, Ma P (2023) Overexpression of SmMYC2 enhances salt resistance in Arabidopsis thaliana and Salvia miltiorrhiza hairy roots. J Plant Physiol 280:153862. https://doi.org/10.1016/J.JPLPH.2022.153862

Article