Neuroretinitis is an ocular disorder that can be caused by infectious or non-infectious diseases and is characterized by optic disc edema and macular star formation. It typically occurs in the third or fourth decade of life, with no gender-related difference. Bartonella henselae is the causative agent in 2/3 of cases. Other causes of neuroretinitis include idiopathic origins; inflammatory diseases, such as sarcoidosis, inflammatory bowel disease, and polyarteritis nodosa; and infectious diseases, such as Toxoplasmosis gondii, syphilis, tuberculosis, leptospirosis, and Lyme disease [1].

Neuroretinitis can result in various ocular complications, including retinal artery occlusion, serous retinal detachment, vitreous hemorrhage, and macular holes [2]. In the literature, there is a small number of cases in which a full-thickness macular hole (FTMH) developed secondary to neuroretinitis.

In this report, we aim to present the treatment of resistant FTMH cases developing secondary to neuroretinitis using amniotic membrane transplantation (AMT).