Impact of morbid obesity on surgical and oncological outcomes in patients with endometrial cancer undergoing robotic assisted laparoscopic hysterectomy and pelvic lymph node staging

Endometrial cancer represents the fourth cause of cancer in women in France, with over 8000 cases per year in 2018 [1,2]. Gold-standard surgery for most cases is total hysterectomy and bilateral adnexectomy with pelvic lymph node staging which is amenable to minimally invasive surgery [3]. Indeed, compared to open surgery, conventional and robotic assisted laparoscopy allow to have significantly more favorable perioperative outcomes (less bleeding, shorter hospital stays, use of less pain-relieving medication) without impacting oncological outcomes [[4], [5], [6]].

Obesity is a significant risk factor for endometrial cancer and approximately 60 % of patients with this disease have a Body Mass Index (BMI) > 30 kg/m [7,8]. In this specific population, several perioperative challenges, due to increasing BMI and comorbid condition, exist and can lead to important surgical morbidity [9]. Although minimally invasive approach has been shown to be the surgical technique of choice to reduce operative complications, conventional laparoscopy has limitations and notably in patients with very high BMI [10]. In those cases, robotic assisted laparoscopy may have more interest for the ergonomic impacts on the surgical team: articulated instruments, 3-D visualization, tremor reduction, shorter learning curve, and decreased pneumoperitoneum insufflation pressures [[11], [12], [13]]. Moreover, some studies demonstrated that robotic assisted laparoscopy has less blood loss and shorter hospital stays in very obese patients [12,14,15].

Morbid obesity can still impact perioperative outcomes even in robotic assisted laparoscopy. The aim of our retrospective study was to compare surgical and oncological outcomes between patients with BMI < 35 kg/m2 and patients with BMI ≥ 35 kg/m2 (morbid obesity) who underwent robotic assisted laparoscopic total hysterectomy with bilateral adnexectomy and pelvic lymph node staging.

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