Kinthada LK, Medisetty SR, Parida A, Babu KN, Bisai A (2017) FeCl3- catalyzed allylation reactions onto 3-Hydroxy-2-oxindoles: formal total syntheses of Bis-cyclotryptamine Alkaloids,(±)-Chimonanthine, and (±)- Folicanthine. J Org Chem 82(16):8548–8567. https://doi.org/10.1021/acs.joc.7b01232

Article  PubMed  CAS  Google Scholar 

Kumar RS, Almansour AI, Arumugam N, Soliman SM, Kumar PR, Altaf M, Ghabbour HA, Krishnamoorthy BS (2018) Stereoselective green synthesis and molecular structures of highly functionalized spirooxindolepyrrolidine hybrids–A combined experimental and theoretical investigation. J Mol Stru 1152:266–275. https://doi.org/10.1016/j.molstruc.2017.09.073

Article  CAS  Google Scholar 

Rudrangi RS, Bontha VK, Manda VR, Bethi S (2011) Oxindoles and their pharmaceutical significance-an overview. Asian J Res Chem 4(3):335–338

Google Scholar 

Xu Q, Wang D, Wei Y, Shi M (2014) Highly efficient and stereoselective construction of Bispirooxindole derivatives via a Three-Component 1, 3‐Dipolar cycloaddition reaction. Chem Open 3(3):93–98. https://doi.org/10.1002/open.201402003

Article  CAS  Google Scholar 

Millemaggi A, Taylor RJ (2010) 3-Alkenyl‐oxindoles: natural products, pharmaceuticals, and recent synthetic advances in tandem/telescoped approaches. Eur J Org Chem 24:4527–4547. https://doi.org/10.1002/ejoc.201000643

Article  CAS  Google Scholar 

Sun Y, Liu J, Sun T, Zhang X, Yao J, Kai M, Jiang X, Wang R (2014) Anticancer small molecule JP-8 g exhibits potent in vivo anti-inflammatory activity. Sci Rep 14(4):4372–4377. https://doi.org/10.1038/srep04372

Article  CAS  Google Scholar 

Galliford CV, Scheidt KA (2007) Pyrrolidinyl-Spirooxindole natural products as inspirations for the development of potential therapeutic agents. Angew Chem Int Ed 46(46):8748–8758. https://doi.org/10.1002/anie.200701342

Article  CAS  Google Scholar 

Ding K, Lu Y, Nikolovska-Coleska Z, Qiu S, Ding Y, Gao W, Stuckey J, Krajewski K, Roller PP, Tomita Y, Parrish DA (2005) Structurebased design of potent non-peptide MDM2 inhibitors. J Am Chem Soc 127(29):10130–10131. https://doi.org/10.1021/ja051147z

Article  PubMed  CAS  Google Scholar 

Barakat A, Mostafa A, Ali M, Al-Majid AM, Domingo LR, Kutkat O, Moatasim Y, Zia K, Ul-Haq Z, Elshaier YAMM (2022) Design, synthesis and in vitro evaluation of Spirooxindole-Based phenylsulfonyl moiety as a candidate Anti-SAR-CoV-2 and MERS-CoV-2 with the implementation of combination studies. Int J Mol Sci 23(19):11861–11821. https://doi.org/10.3390/ijms231911861

Article  PubMed  PubMed Central  CAS  Google Scholar 

El-Kalyoubi SA, Ragab A, Abu Ali OA, Ammar YA, Seadawy MJ, Ahmed A, Fayed EA (2022) One-pot synthesis and molecular modeling studies of new bioactive spiro-oxindoles based on uracil derivatives as sars-cov-2 inhibitors targeting Rna polymerase and Spike glycoprotein. Pharmaceuticals 15(3):376–389. https://doi.org/10.3390/ph15030376

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang MZ, Chen Q, Yang GF (2015) A reviews on recent developments of indole-containing antiviral agents. Eur J Med Chem 89:421–441. https://doi.org/10.1016/j.ejmech.2014.10.065

Article  PubMed  CAS  Google Scholar 

Girgis AS (2009) Regioselective synthesis of dispiro [1H-indene-2, 3′- pyrrolidine-2′, 3 ″-[3H] indole]-1, 2 ″(1 ″H)-diones of potential anti-tumor properties. Eur J Med Chem 44(1):91–100. https://doi.org/10.1016/j.ejmech.2008.03.013

Article  PubMed  CAS  Google Scholar 

Murugan R, Anbazhagan S, Narayanan SS (2009) Synthesis and in vivo antidiabetic activity of novel dispiropyrrolidines through [3 + 2] cycloaddition reactions with Thiazolidinedione and Rhodanine derivatives. Euro J Med Chem 44(8):3272–3279. https://doi.org/10.1016/j.ejmech.2009.03.035

Article  CAS  Google Scholar 

Feng GL, Li Y, Geng LG (2015) A facile regioselective 1, 3-Dipolar cycloaddition reaction for the synthesis of Dispiro[Indole-3,2-Pyrrolidine-3′,5″-[1,3]Thiazolidine] derivatives. J Chem Res 39:134–139. https://doi.org/10.3184/174751915X14231323398218

Article  CAS  Google Scholar 

Coldham I, Hufton R (2005) Intramolecular dipolar cycloaddition reactions of azomethine ylides. Chem Rev 105(7):2765–2810. https://doi.org/10.1021/cr040004c

Article  PubMed  CAS  Google Scholar 

Pandey G, Banerjee P, Gadre SR (2006) Construction of enantiopure pyrrolidine ring system via asymmetric [3 + 2]-cycloaddition of azomethine ylides. Chem Rev 106(11):4484–4517. https://doi.org/10.1021/cr050011g

Article  PubMed  CAS  Google Scholar 

Ruck-Braun K, Wierschem F (2005) 1, 3-Dipolar cycloaddition on solid supports: nitrone approach towards isoxazolidines and isoxazolines and subsequent transformations. Chem Soc Rev 34(6):507–516. https://doi.org/10.1039/B311200B

Article  PubMed  Google Scholar 

Li J, Wang J, Xu Z, Zhu S (2014) Combinatorial synthesis of functionalized Spirooxindole-Pyrrolidine/Pyrrolizidine/Pyrrolothiazole derivatives via Three-Component 1,3-Dipolar cycloaddition reactions. ACS Comb Sci 16(9):506–512. https://doi.org/10.1021/co500085t

Article  PubMed  CAS  Google Scholar 

Orru RVA, de Greef M (2003) Recent advances in So- lution-Phase multicomponent methodology for the synthesis of heterocyclic compounds. Synthesis 10:1471–1499. https://doi.org/10.1055/s-2003-40507

Article  Google Scholar 

Poornachandran M, Raghunathan R (2006) Synthesis of dispirooxindolecycloalka [d] Pyrimidino [2, 3-b]-thiazole pyrrolidine/thiapyrrolizidine ring systems. Tetrahedron 62(48):11274–11281. https://doi.org/10.1016/j.tet.2006.09.008

Article  CAS  Google Scholar 

Yang J, Liu XW, Wang DD, Tian MY, Han SN, Feng TT, Liu XL, Mei RQ, Zhou Y (2016) Diversity-oriented one-pot multicomponent synthesis of Spirooxindole derivatives and their biological evaluation for anticancer activities. Tetrahedron 72(52):8523–8536. https://doi.org/10.1016/j.tet.2016.10.050

Article  CAS  Google Scholar 

Hu Y, Zou Y, Wu H, Shi D (2012) A facile and efficient ultrasound-assisted synthesis of novel dispiroheterocycles through 1, 3-dipolar cycloaddition reactions. Ultrason Sonochem 19(2):264–269. https://doi.org/10.1016/j.ultsonch.2011.07.006

Article  PubMed  CAS  Google Scholar 

Hamzehloueian M, Sarrafi Y, Aghaei Z (2015) An experimental and theoretical study on the regioselective synthesis of a new class of spiropyrrolothiazoles with Quinoxaline motifs via a 1, 3-dipolar cycloaddition reaction. An evaluation of DFT method. RSC Adv 5:76368–76376. https://doi.org/10.1039/C5RA14071D

Article  CAS  Google Scholar 

Ponnala S, Sahu DP, Kumar R, Maulik PR (2006) One pot synthesis of novel dispiro[oxindole-thiazolidinedione/thioxo-thiazolidinone/dihydro pyrazolone]-pyrrolidines via 1,3-dipolar cycloaddition reaction of azomethine ylides. J Heterocycl Chem 43(6):1635–1640. https://doi.org/10.1002/jhet.5570430631

Article  CAS  Google Scholar 

Sutariya TR, Brahmbhatt GC, Atara HD, Parmar NJ, Kant R, Gupta VK, Lagunes I, Padrón JM, Murumkar PR, Sharma MK, Yadav MR (2024) An efficient one-pot synthesis and Docking studies of bioactive new antiproliferative dispiro[oxindole/acenaphthylenone–benzofuranone] pyrrolidine scaffolds. Mol Divers 28(5):3165–3180. https://doi.org/10.1007/s11030-023-10741-4

Article  PubMed  CAS  Google Scholar 

Hammouda MB, Boudriga S, Hamden K, Askri M, Knorr M, Strohmann C, Brieger L, Krupp A, Anouar EH, Snoussi M, Aouadi K, Kadri A (2022) New spiropyrrolothiazole derivatives bearing an Oxazolone moiety as potential antidiabetic agent: design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular Docking studies. J Mol Struct 1254:132398–132418. https://doi.org/10.1016/j.molstruc.2022.132398

Article  CAS  Google Scholar 

Li X, Zhang Y, Liu J, Cao J, Ma N, Tao M, Zhang W (2024) Synthesis of spiroindoline derivatives and biphenyl compounds in green solvent via a capture–release mechanism using modified polyacrylonitrile fiber as a catalyst. Chem Eng J 496:153906–153918. https://doi.org/10.1016/j.cej.2024.153906

Article  CAS  Google Scholar 

Liu H, Zou Y, Hu Y, Shi DQ (2011) An efficient one-pot synthesis of Dispiropyrrolidine derivatives through 1, 3-dipolar cycloaddition reactions under ultrasound irradiation. J Heterocycl Chem 48(4):877–881. https://doi.org/10.1002/jhet.654

Article  CAS  Google Scholar 

Barakat A, Soliman SM, Al-Majid AM, Ali M, Islam MS, Elshaier YA, Ghabbour HA (2018) New spiro-oxindole constructed with pyrrolidine/thioxothiazolidin-4-one derivatives: regioselective synthesis, X-ray crystal structures, Hirshfeld surface analysis, DFT, Docking and antimicrobial studies. J Mol Struct 1152:101–114. https://doi.org/10.1016/j.molstruc.2017.09.086

Article  CAS  Google Scholar