Calprotectin inhibition attenuates silica-induced lung fibrosis

Benmerzoug S et al (2018) STING-dependent sensing of self-DNA drives silica-induced lung inflammation. Nat Commun 9(1):5226

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bergna HE (1994) Colloid chemistry of silica. The colloid chemistry of silica. American Chemical Society, Washington, DC, pp 1–47

Chapter  Google Scholar 

Bhagia LJ (2012) Non-occupational exposure to silica dust. Indian J Occup Environ Med 16(3):95–100

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bormann T et al (2022) Role of matrix metalloprotease-2 and MMP-9 in experimental lung fibrosis in mice. Respir Res 23(1):180

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bredeck G et al (2023) Inhalable Saharan dust induces oxidative stress, NLRP3 inflammasome activation, and inflammatory cytokine release. Environ Int 172:107732

Article  CAS  PubMed  Google Scholar 

Carlos M et al (2021) Serum calprotectin as new biomarker for disease severity in idiopathic pulmonary fibrosis: a cross-sectional study in two independent cohorts. BMJ Open Respir Res 8(1):e000827

Article  Google Scholar 

Chen T et al (2014) Epithelial–mesenchymal transition involved in pulmonary fibrosis induced by multi-walled carbon nanotubes via TGF-beta/Smad signaling pathway. Toxicol Lett 226(2):150–162

Article  CAS  PubMed  Google Scholar 

Cheng F et al (2016) Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β–Slug signaling. Proc Natl Acad Sci 113(30):E4320–E4327

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ciambarella BT et al (2025) TNF-alpha mediates airway hyperreactivity in silicotic mice: effect of thalidomide treatment. Eur J Pharmacol 990:177263

Article  CAS  PubMed  Google Scholar 

Fernandez IE, Eickelberg O (2012) The impact of TGF-β on lung fibrosis. Proc Am Thorac Soc 9(3):111–116

Article  CAS  PubMed  Google Scholar 

Friedrich M et al (2021) IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies. Nat Med 27(11):1970–1981

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gairola S, Sinha A, Kaundal RK (2024) Linking NLRP3 inflammasome and pulmonary fibrosis: mechanistic insights and promising therapeutic avenues. Inflammopharmacology 32(1):287–305

Article  CAS  PubMed  Google Scholar 

Gilberti RM, Joshi GN, Knecht DA (2008) The phagocytosis of crystalline silica particles by macrophages. Am J Respir Cell Mol Biol 39(5):619–627

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gordon IO et al (2020) Histopathology scoring systems of stenosis associated with small bowel Crohn’s disease: a systematic review. Gastroenterology 158(1):137-150.e1

Article  PubMed  Google Scholar 

Greenberg MI, Waksman J, Curtis J (2007) Silicosis: a review. Dis Mon 53(8):394–416

Article  PubMed  Google Scholar 

Guo Q et al (2021) Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host Microbe 29(2):222-235.e4

Article  CAS  PubMed  Google Scholar 

Holmgaard DB et al (2013) Calprotectin—a marker of mortality in COPD? Results from a prospective cohort study. COPD J Chron Obstruct Pulm Dis 10(5):581–587

Article  Google Scholar 

Huo C et al (2024) Silica aggravates pulmonary fibrosis through disrupting lung microbiota and amino acid metabolites. Sci Total Environ 945:174028

Article  CAS  PubMed  Google Scholar 

Iversen IB et al (2024) Occupational exposure to respirable crystalline silica and incident idiopathic interstitial pneumonias and pulmonary sarcoidosis: a national prospective follow-up study. Occup Environ Med 81(6):279

Article  PubMed  Google Scholar 

Jia Q et al (2024) Investigation of the mechanism of silica-induced pulmonary fibrosis: the role of lung microbiota dysbiosis and the LPS/TLR4 signaling pathway. Sci Total Environ 912:168948

Article  CAS  PubMed  Google Scholar 

Jukic A et al (2021) Calprotectin: from biomarker to biological function. Gut 70(10):1978–1988

Article  CAS  PubMed  Google Scholar 

Kim DH et al (2020) Suppressive effects of S100A8 and S100A9 on neutrophil apoptosis by cytokine release of human bronchial epithelial cells in asthma. Int J Med Sci 17(4):498–509

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuley R et al (2025) Neutrophil activation markers and rheumatoid arthritis treatment response to the JAK1/2 inhibitor baricitinib. Arthritis Rheumatol 77(4):395–404

Article  CAS  PubMed  Google Scholar 

Lam M et al (2025) NLRP3 deficiency abrogates silica-induced neutrophil infiltration, pulmonary damage and fibrosis. Respir Res 26(1):109

Article  CAS  PubMed  PubMed Central  Google Scholar 

Linch KD et al (1998) Surveillance of respirable crystalline silica dust using OSHA compliance data (1979–1995). Am J Ind Med 34(6):547–558

Article  CAS  PubMed  Google Scholar 

Ma R et al (2024) Tetrandrine alleviates silica-induced pulmonary fibrosis through PI3K/AKT pathway: network pharmacology investigation and experimental validation. Inflammation 47(4):1109–1126

Article  CAS  PubMed  Google Scholar 

Madala SK et al (2012) MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation. Am J Respir Cell Mol Biol 46(3):380–388

Article  CAS  PubMed  PubMed Central  Google Scholar 

Majster M, Almer S, Boström EA (2019) Salivary calprotectin is elevated in patients with active inflammatory bowel disease. Arch Oral Biol 107:104528

Article  CAS  PubMed  Google Scholar 

Matute-Bello G et al (2011) An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol 44(5):725–738

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mdkhana B et al (2023) Nucleic acid sensor STING drives remodeling and its inhibition enhances steroid responsiveness in chronic obstructive pulmonary disease. PLoS ONE 18(7):e0284061

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nie W et al (2022) Crystalline silica induces macrophage necrosis and causes subsequent acute pulmonary neutrophilic inflammation. Cell Biol Toxicol 38(4):591–609

Article  CAS  PubMed  Google Scholar 

Nishikawa Y et al (2017) Calprotectin induces IL-6 and MCP-1 production via toll-like receptor 4 signaling in human gingival fibroblasts. J Cell Physiol 232(7):1862–1871

Article  CAS 

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