We use publicly available data. Genetic and image derived phenotypes were obtained from the UK Biobank under Application Number 19526 and 89052. GWAS summary statistics were downloaded from the public domain (url in Table S6). BrainXcan software is available at https://github.com/hakyimlab/brainxcan. We are sharing image derived phenotypes prediction models at https://doi.org/10.5281/zenodo.4895174. The analysis code is at https://github.com/liangyy/ukb_idp_genetic_arch. Phi estimation code is at https://github.com/hakyimlab/twas-inflation

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