Document Type : review article

Authors

1 Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Clinical Research Development Unit of Akbar Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

10.22038/jpp.2025.88294.5554

Abstract

Auto-inflammatory diseases (AIDs) are a diverse group of disorders characterized by inappropriate activation of the innate immune system, leading to chronic inflammation. In children, these conditions can significantly impact multiple organs, including the kidneys. This review article is based on the most recent studies published after 2020, focusing on various auto-inflammatory diseases and their impact on kidney function. The review aims to provide a comprehensive overview of auto-inflammatory diseases and their renal involvement in pediatric patients, focusing on advancements in understanding the molecular mechanisms, diagnostic strategies, and treatment options. By examining the latest research, this article aims to enhance clinical awareness of renal manifestations and improve management strategies for pediatric rheumatologists.

Keywords