Interrelationship between type 2 diabetes mellitus and obstructive sleep apnea: Experts’ opinion with focus on development of a screening tool

Goyal R, Singhal M, Jialal I. Type 2 Diabetes. [Updated 2023 Jun 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK513253/

Obesity and Type 2 Diabetes: a Joint Approach to Halt the Rise A Policy Brief by the International Diabetes Federation and the World Obesity Federation. Available at: https://idf.org/media/uploads/2022/11/IDF-WOF-Obesity-and-type-2-diabetes_A-joint-approach-to-halt-the-rise-WEB-2.pdf Accessed 28 June 2024

International Diabetes Federation. https://idf.org/about-diabetes/diabetes-facts-figures/ Accessed 18 December 2023

IDF Diabetes Atlas 10th edition. https://diabetesatlas.org/data/en/country/93/in.htmlhttps://idf.org/our-network/regions-and-members/south-east-asia/members/india/ Accessed 16 December 2023

Anjana RM, Unnikrishnan R, Deepa M, Pradeepa R, Tandon N, Das AK, et al. ICMR-INDIAB Collaborative Study Group. Metabolic non-communicable disease health report of India: the ICMR-INDIAB national cross-sectional study (ICMR-INDIAB-17). Lancet Diabetes Endocrinol. 2023;11(7):474–89.

Article  PubMed  Google Scholar 

Das AK, Kalra S, Joshi S, Das AK, Kalra S, Joshi S, et al. LANDMARC study group. The LongitudinAl Nationwide stuDy on Management And Real-world outComes of diabetes in India over 3 years (LANDMARC trial). Endocrinol Diab Metab. 2023;6(5):e0422.

Article  Google Scholar 

Doumit J, Prasad B. Sleep Apnea in Type 2 Diabetes. Diabetes Spectr. 2016;29(1):14–9.

Article  PubMed  PubMed Central  Google Scholar 

de Araujo Dantas AB, Gonçalves FM, Martins AA, Alves GÂ, Stechman-Neto J, Corrêa CC, et al. Worldwide prevalence and associated risk factors of obstructive sleep apnea: a meta-analysis and meta-regression. Sleep Breath. 2023;27(6):2083–109.

Article  PubMed  Google Scholar 

Pamidi S, Tasali E. Obstructive sleep apnea and type 2 diabetes: is there a link? Front Neurol. 2012;3:126.

Article  PubMed  PubMed Central  Google Scholar 

Singh A, Chaudhary SC, Gupta KK, Sawlani KK, Singh A, Singh AB, et al. Prevalence of obstructive sleep apnea in diabetic patients. Ann Afr Med. 2021;20(3):206–11.

Article  PubMed  PubMed Central  Google Scholar 

Fallahi A, Jamil DI, Karimi EB, Baghi V, Gheshlagh RG. Prevalence of obstructive sleep apnea in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Metab Syndr. 2019;13(4):2463–8.

Article  PubMed  Google Scholar 

Saxena P, Singh D, Singh Y. Prevalence and impact of obstructive sleep apnea in type 2 diabetes mellitus: A descriptive cross-sectional study. Medical J Armed Forces India. 2024;80(supplement 1):S50–6. https://doi.org/10.1016/j.mjafi.2022.07.008.

Article  Google Scholar 

Schwartz AR, Patil SP, Squier S, Schneider H, Kirkness JP, Smith PL. Obesity and upper airway control during sleep. J Appl Physiol. 2010;108(2):430–5.

Article  PubMed  Google Scholar 

Eckert DJ, Oliven A. When insulin has to work hard to keep the sugar at bay the upper airway collapses away. Eur Respir J. 2016;47:1611–4.

Article  CAS  PubMed  Google Scholar 

Framnes SN, Arble DM. The Bidirectional Relationship Between Obstructive Sleep Apnea and Metabolic Disease. Front Endocrinol (Lausanne). 2018;9:440.

Article  PubMed  Google Scholar 

Kheirandish-Gozal L, Gozal D. Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines. Int J Mol Sci. 2019;20(3):459.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Loredo JS, Ziegler MG, Ancoli-Israel S, Clausen JL, Dimsdale JE. Relationship of arousals from sleep to sympathetic nervous system activity and BP in obstructive sleep apnea. Chest. 1999;116:655–9.

Article  CAS  PubMed  Google Scholar 

Lee CP, Kushida CA, Abisheganaden JA. Epidemiological and pathophysiological evidence supporting links between obstructive sleep apnoea and Type 2 diabetes mellitus. Singapore Med J. 2019;60(2):54–6. https://doi.org/10.11622/smedj.2019015.

Article  PubMed  PubMed Central  Google Scholar 

Swaroop JJ, Rajarajeswari D, Naidu JN. Association of TNF-α with insulin resistance in type 2 diabetes mellitus. Indian J Med Res. 2012;135(1):127–30. https://doi.org/10.4103/0971-5916.93435.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen H, Zhao J, Liu Y, Sun G. Interactions between and Shared Molecular Mechanisms of Diabetic Peripheral Neuropathy and Obstructive Sleep Apnea in Type 2 Diabetes Patients. J Diabetes Res. 2018;19(2018):3458615. https://doi.org/10.1155/2018/3458615.

Article  CAS  Google Scholar 

Arnardottir ES, Mackiewicz M, Gislason T, Teff KL, Pack AI. Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep. 2009;32(4):447–70. https://doi.org/10.1093/sleep/32.4.447.

Article  PubMed  PubMed Central  Google Scholar 

Rajkov B, Zdravković M, Ninić A, Brajković M, Klašnja S, Gardijan V, Memon L, Munjas J, Mihajlović M, Spasojević-Kalimanovska V, Radosavljević V, Sopić M. Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus. Sleep Breath. 2023;27(5):2031–9. https://doi.org/10.1007/s11325-023-02809-0.

Article  PubMed  Google Scholar 

Strausz S, Ruotsalainen S, Ollila HM, Karjalainen J, Kiiskinen T, Reeve M, et al. Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health. Eur Respir J. 2021;57(5):2003091. https://doi.org/10.1183/13993003.03091-2020

Shechter A. Obstructive sleep apnea and energy balance regulation: A systematic review. Sleep Med Rev. 2017;34:59–69.

Article  PubMed  Google Scholar 

Reutrakul S, Siwasaranond N, Nimitphong H, Saetung S, Chirakalwasan N, Chailurkit LO, et al. Associations between nocturnal urinary 6-sulfatoxymelatonin, obstructive sleep apnea severity and glycemic control in type 2 diabetes. Chronobiol Int. 2017;34:382–92.

Article  CAS  PubMed  Google Scholar 

Peschke E, Muhlbauer E. New evidence for a role of melatonin in glucose regulation. Best Pract Res Clin Endocrinol Metab. 2010;24:829–41.

Article  CAS  PubMed  Google Scholar 

Peschke E, Frese T, Chankiewitz E, Peschke D, Preiss U, Schneyer U, et al. Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status. J Pineal Res. 2006;40:135–43.

Article  CAS  PubMed  Google Scholar 

McMullan CJ, Schernhammer ES, Rimm EB, Hu FB, Forman JP. Melatonin secretion and the incidence of type 2 diabetes. JAMA. 2013;309:1388–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amin A, Ali A, Altaf QA, Piya MK, Barnett AH, Raymond NT, et al. Prevalence and associations of obstructive sleep apnea in South Asians and White Europeans with type 2 diabetes: a cross-sectional study. J Clin Sleep Med. 2017;13(4):583–9.

Article  PubMed  PubMed Central  Google Scholar 

Viswanathan V, Ramalingam IP, Ramakrishnan N. High Prevalence of Obstructive Sleep Apnea among People with Type 2 Diabetes Mellitus in a Tertiary Care Center. J Assoc Physicians India. 2017;65:38–42.

PubMed  Google Scholar 

Andayeshgar B, Janatolmakan M, Soroush A, et al. The prevalence of obstructive sleep apnea in patients with type 2 diabetes: a systematic review and meta-analysis. Sleep Science Practice. 2022;6:6. https://doi.org/10.1186/s41606-022-00074-w.

Article  Google Scholar 

Bhimwal RK, Makwana M, Jangid R, Bhati RL. To study the prevalence of obstructive sleep apnoea in type 2 diabetes patients in Western Rajasthan. India Int J Adv Med. 2017;4(4):894–902.

Article  Google Scholar 

Abdissa D. Prevalence of obstructive sleep apnea risk and associated factors among patients with type 2 diabetes mellitus on follow up at Jimma Medical Center. Southwest Ethiopia J Clin Transl Endocrinol. 2020;21: 100234.

PubMed  Google Scholar 

Sweed RA, Wahab NHAE, El Hooshy MS, et al. Obstructive sleep apnea in patients with type 2 diabetes mellitus in Egyptian population. Egypt J Bronchol. 2023;17:55.

Article  Google Scholar 

Bixler EO, Vgontzas AN, Ten Have T, Tyson K, Kales A. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med. 1998;157(1):144–8. https://doi.org/10.1164/ajrccm.157.1.9706079.

Article  CAS  PubMed  Google Scholar 

Kumar P, Rai DK, Kanwar MS. Comparison of clinical and polysomnographic parameters between obese and nonobese obstructive sleep apnea. J Family Med Prim Care. 2020;9(8):4170–3. https://doi.org/10.4103/jfmpc.jfmpc_56_20.

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