Involvement of the tryptophan-kynurenine pathway in the pathogenesis of autoimmune diseases

AbbreviationsACMSD

α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase

AIA

adjuvant-induced arthritis

AhR

aryl hydrocarbon receptor

CIA

collagen-induced arthritis

DSS

dextran sulfate sodium

EAE

experimental autoimmune encephalomyelitis

FLS

fibroblast-like synoviocytes

GPR35

G-protein-coupled receptor 35

HAAO

3-hydroxyanthranilate 3,4-dioxygenase

IBD

inflammatory bowel diseases

IDO1

indoleamine 2,3-dioxygenase 1

mTOR

mammalian target of rapamycin

NAD+

nicotinamide adenine dinucleotide

KAT

kynurenine amino-transferase

KMO

kynurenine 3-monooxygenase

PBMC

peripheral blood mononuclear cells

PPMS

primary progressive MS

PRMS

progressive-relapsing MS

pSS

primary Sjogren's syndrome

QPRT

quinolinic phosphate ribosyltransferase

RRMS

relapsing-remitting MS

SLE

systemic lupus erythematosus

SPMS

secondary progressive MS

TDO2

tryptophan 2,3-dioxygenase 2

TGF-β

transforming growth factor-β

TNBS

2,4,6-trinitrobenzene sulfonic acid

TNF-α

tumor necrosis factor-α

US-MSCs

umbilical cord derived mesenchymal stem cells

3,4-DAA

N-(3′,4′-Dimethoxycinnamonyl) anthranilic acid

3-HAA

3-hydroxyanthranilic acid

Keywords

Autoimmune disease

Tryptophan

Kynurenine pathway

Indoleamine 2,3-dioxygenase

Tryptophan 2,3- dioxygenase

Metabolism

Comments (0)

No login
gif