This clinical report presents a novel approach for rehabilitating of a 59-year-old man with a severe nasal defect resulting from a high-voltage electrical burn injury. The digital workflow utilized 3-dimensional (3D) facial scanning, computer-aided design (CAD), and 3D printing to fabricate a custom nasal prosthesis. The defect was first captured using a handheld 3D scanner, allowing for precise modeling in a CAD software program based on pre-injury photographs. A trial prosthesis was fabricated and clinically evaluated for esthetics and fit. To secure the definitive prosthesis, a custom-designed nose pad retention system was integrated into the definitive prosthesis, to attach to the patient’s eyeglasses, providing stable retention without adhesives. This attachment system offered the benefits of comfort, ease of use, and the flexibility of using different eyeglass frames as needed. The use of a fully digital workflow enabled the production of an anatomically accurate, esthetically satisfactory, and patient-centered nasal prosthesis. This treatment approach demonstrated the potential of digital workflows in maxillofacial prosthetics, particularly for complex facial defects, by reducing treatment time, enhancing esthetic outcomes, and improving patient satisfaction.