Available online 9 August 2025

Oral cancer and subsequent surgical interventions can lead to orofacial deformities that significantly affect a patient’s Oral Health Related Quality of Life (OHRQoL) by impairing essential functions, causing pain and psychological discomfort, and creating physical, psychological, and social disabilities. Studies on the impact of prosthetic rehabilitation for oral cancer on the OHRQoL are sparse.

The purpose of the present prospective case series was to evaluate the impact of prosthetic rehabilitation on the OHRQoL of patients with postsurgical defects from oral cancer and determine the clinical significance of these changes.

This prospective case series enrolled 20 consenting adults with unilateral maxillary, mandibular, or tongue defects after surgical resection for oral cancer. Using the Oral Health Impact Profile-14 (OHIP-14), participants completed baseline surveys during the initial postsurgical prosthodontic appointment, and final surveys were completed 1 month after the definitive maxillofacial prosthesis had been delivered. The survey provided a comprehensive measure of patient changes attributable to their oral conditions. OHIP-14 has a total score and 7 domains: Functional Limitation, Physical Pain, Psychological Discomfort, Physical Disability, Psychological Disability, Social Disability, and Handicap. Statistical analyses evaluated the changes in OHIP-14 scores by subtracting the final scores from the baseline scores. The paired t test evaluated changes in the OHIP-14 (α=.05). The effect size for the change in the overall OHIP-14 score from baseline to final was assessed using the Cohen d to quantify the magnitude and clinical significance of the observed changes.

Improvement from baseline to 1-month after insertion was statistically significant for the OHIP-14 total score (P<.001) and for all domains (all P≤003). Clinically significant improvement was observed for the OHIP-14 total score with a change of −15 points, which was greater than the minimal important difference of 3 to 4 points. Using the Cohen d, changes in 6 of the 7 domains had a big effect (range of d: −0.95 to −1.80) with Social Disability, Psychological Disability, and Handicap having the biggest effects.

The findings of the present prospective case series demonstrate both statistically and clinically significant improvements in the OHRQoL of participants. The magnitude of the effect size for the change in OHIP total score indicated that the prosthetic rehabilitation of surgical defects had a substantial impact on OHRQoL, with the most improvement in the Social Disability domain.

Copyright © 2025 The Authors. Published by Elsevier Inc. on behalf of the Editorial Council of The Journal of Prosthetic Dentistry.