Li, Z., Zhang, Z., Ren, Y., Wang, Y., Fang, J., Yue, H., Ma, S., & Guan, F. (2021). Aging and age-related diseases: From mechanisms to therapeutic strategies. Biogerontology, 22, 165–187. https://doi.org/10.1007/s10522-021-09910-5.
Article PubMed PubMed Central Google Scholar
Fekete, M., Szarvas, Z., Fazekas-Pongor, V., Feher, A., Csipo, T., Forrai, J., Dosa, N., Peterfi, A., Lehoczki, A., Tarantini, S., & Varga, J. T. (2022). Nutrition strategies promoting healthy aging: From improvement of cardiovascular and brain health to prevention of Age-Associated diseases. Nutrients, 15, 47. https://doi.org/10.3390/nu15010047.
Article CAS PubMed PubMed Central Google Scholar
Wicaksono, D., Taslim, N. A., Lau, V., Syahputra, R. A., Alatas, A. I., Putra, P. P., Tallei, T. E., Tjandrawinata, R. R., Tsopmo, A., Kim, B., & Nurkolis, F. (2024). Elucidation of anti-human melanoma and anti-aging mechanisms of compounds from green seaweed Caulerpa racemosa. Scientific Reports, 14, 27534. https://doi.org/10.1038/s41598-024-78464-6.
Article CAS PubMed PubMed Central Google Scholar
Hayes, C., Nurkolis, F., Laksemi, D. A. A. S., Chung, S., Park, M. N., Choi, M., Choi, J., Darmaputra, I. G. N., Gunawan, W. B., Lele, J. A. J. M. N., Khumaidi, M. A., Taslim, N. A., & Kim, B. (2023). Coffee Silverskin phytocompounds as a novel Anti-Aging functional food: A pharmacoinformatic approach combined with in vitro study. Molecules, 28, 7037. https://doi.org/10.3390/molecules28207037.
Article CAS PubMed PubMed Central Google Scholar
Alum, E. U., Uti, D. E., Egba, S. I., Ugwu, O. P. C., & Aja, P. M. (2025). The role of phytochemicals in Age-Related cognitive decline: A natural solution for brain health. Natural Product Communications, 20, 1934578X251350761. https://doi.org/10.1177/1934578X251350761.
Okoro, N. O., Odiba, A. S., Osadebe, P. O., Omeje, E. O., Liao, G., Fang, W., Jin, C., & Wang, B. (2021). Bioactive phytochemicals with Anti-Aging and lifespan extending potentials in caenorhabditis elegans. Molecules, 26, 7323. https://doi.org/10.3390/molecules26237323.
Article CAS PubMed PubMed Central Google Scholar
Alum, E. U., & Ugwu, O. P. C. (2023). Beyond nutrients: Exploring the potential of phytochemicals for human health. IAA JAS, 10, 1–7. https://doi.org/10.59298/IAAJAS/2023/4.1.3211.
Maldonado, E., Morales-Pison, S., Urbina, F., & Solari, A. (2023). Aging hallmarks and the role of oxidative stress. Antioxidants (Basel), 12, 651. https://doi.org/10.3390/antiox12030651.
Article CAS PubMed Google Scholar
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023). Hallmarks of aging: An expanding universe. Cell, 186, 243–278. https://doi.org/10.1016/j.cell.2022.11.001.
Article CAS PubMed Google Scholar
Alum, E. U. (2022). Antioxidant effect of Buchholzia coriacea ethanol Leaf-Extract and fractions on freund’s Adjuvant-induced arthritis in albino rats: A comparative study. Slovenian Veterinary Research, 59. https://doi.org/10.26873/SVR-1150-2022.
Lee, B. Y., Ordovás, J. M., Parks, E. J., Anderson, C. A. M., Barabási, A. L., Clinton, S. K., de la Haye, K., Duffy, V. B., Franks, P. W., Ginexi, E. M., Hammond, K. J., Hanlon, E. C., Hittle, M., Ho, E., Horn, A. L., Isaacson, R. S., Mabry, P. L., Malone, S., Martin, C. K., Mattei, J., Meydani, S. N., Nelson, L. M., Neuhouser, M. L., Parent, B., Pronk, N. P., Roche, H. M., Saria, S., Scheer, F. A. J. L., Segal, E., Sevick, M. A., Spector, T. D., Van Horn, L., Varady, K. A., Voruganti, V. S., & Martinez, M. F. (2022). Research gaps And opportunities in precision nutrition: An NIH workshop report. American Journal of Clinical Nutrition, 116, 1877–1900. https://doi.org/10.1093/ajcn/nqac237.
Article CAS PubMed PubMed Central Google Scholar
Dwivedi, Y. K., Ismagilova, E., Hughes, D. L., Carlson, J., Filieri, R., Jacobson, J., Jain, V., Karjaluoto, H., Kefi, H., Krishen, A. S., Kumar, V., Rahman, M. M., Raman, R., Rauschnabel, P. A., Rowley, J., Salo, J., Tran, G. A., & Wang, Y. (2021). Setting the future of digital and social media marketing research: Perspectives and research propositions. International Journal of Information Management, 59, 102168. https://doi.org/10.1016/j.ijinfomgt.2020.102168.
Yousefzadeh, M., Henpita, C., Vyas, R., Soto-Palma, C., Robbins, P., & Niedernhofer, L. (2021). DNA damage—how and why we age?. eLife, 10, e62852. https://doi.org/10.7554/eLife.62852.
Article CAS PubMed PubMed Central Google Scholar
Yu, M., Zhang, H., Wang, B., Zhang, Y., Zheng, X., Shao, B., Zhuge, Q., & Jin, K. (2021). Key signaling pathways in aging and potential interventions for healthy aging. Cells, 10, 660. https://doi.org/10.3390/cells10030660.
Article CAS PubMed PubMed Central Google Scholar
Querfurth, H., & Lee, H. K. (2021). Mammalian/mechanistic target of Rapamycin (mTOR) complexes in neurodegeneration. Molecular Neurodegeneration, 16, 44. https://doi.org/10.1186/s13024-021-00428-5.
Article CAS PubMed PubMed Central Google Scholar
Panwar, V., Singh, A., Bhatt, M., Tonk, R. K., Azizov, S., Raza, A. S., Sengupta, S., Kumar, D., & Garg, M. (2023). Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. Sig Transduct Target Ther, 8, 375. https://doi.org/10.1038/s41392-023-01608-z.
Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD + in regulating cellular and metabolic signaling pathways. Mol Metab, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195.
Article CAS PubMed PubMed Central Google Scholar
Guan, G., Chen, Y., & Dong, Y. (2025). Unraveling the AMPK-SIRT1-FOXO pathway: The In-Depth analysis and breakthrough prospects of oxidative Stress-Induced diseases. Antioxidants (Basel), 14, 70. https://doi.org/10.3390/antiox14010070.
Article CAS PubMed Google Scholar
Gupta, A., & Singh, R. (2025). AMP-Activated protein kinase (AMPK): A cellular energy sensor and the guardian of metabolism. International Journal of Biochemistry Research & Review, 34, 147–153. https://doi.org/10.9734/ijbcrr/2025/v34i2972.
Fakhri, S., Moradi, S. Z., Moradi, S. Y., Piri, S., Shiri Varnamkhasti, B., Piri, S., Khirehgesh, M. R., Bishayee, A., Casarcia, N., & Bishayee, A. (2024). Phytochemicals regulate cancer metabolism through modulation of the AMPK/PGC-1α signaling pathway. Bmc Cancer, 24, 1079. https://doi.org/10.1186/s12885-024-12715-7.
Article CAS PubMed PubMed Central Google Scholar
Qian, L., Zhu, Y., Deng, C., Liang, Z., Chen, J., Chen, Y., Wang, X., Liu, Y., Tian, Y., & Yang, Y. (2024). Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases. Signal Transduct Target Ther, 9, 50. https://doi.org/10.1038/s41392-024-01756-w.
Article CAS PubMed PubMed Central Google Scholar
García-Juan, M., Villa, M., Benito-Cuesta, I., Ordóñez-Gutiérrez, L., & Wandosell, F. (2024). Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system. Neural Regen Res, 20, 3209–3210. https://doi.org/10.4103/NRR.NRR-D-24-00733.
Article CAS PubMed PubMed Central Google Scholar
Ahmed, M. (2025). Targeting aging pathways with natural compounds: A review of curcumin, Epigallocatechin gallate, thymoquinone, and Resveratrol. Immun Ageing, 22, 28. https://doi.org/10.1186/s12979-025-00522-y.
Article PubMed PubMed Central Google Scholar
Uti, D. E., Atangwho, I. J., Alum, E. U., Ntaobeten, E., Obeten, U. N., Bawa, I., Agada, S. A., Ukam, C. I. O., & Egbung, G. E. (2025). Antioxidants in cancer therapy mitigating lipid peroxidation without compromising treatment through nanotechnology. Discover Nano, 20, 70. https://doi.org/10.1186/s11671-025-04248-0.
Article CAS PubMed PubMed Central Google Scholar
García-García, V. A., Alameda, J. P., Page, A., & Casanova, M. L. (2021). Role of NF-κB in ageing and Age-Related diseases: Lessons from genetically modified mouse models. Cells, 10, 1906. https://doi.org/10.3390/cells10081906.
Article CAS PubMed PubMed Central Google Scholar
Cui, X., Wang, Y., & Fu, J. (2025). DNA damage response and cell fate decisions across the lifespan: From fetal development to age-related respiratory diseases. Cell Biosci, 15, 114. https://doi.org/10.1186/s13578-025-01442-6.
Comments (0)