Lunghi C, Antonazzo IC, Burato S, Raschi E, Zoffoli V, Forcesi E, et al. Prevalence and determinants of Long-Term utilization of antidepressant drugs: A retrospective cohort study. Neuropsychiatr Dis Treat. 2020;16:1157–70.
Article CAS PubMed PubMed Central Google Scholar
Geddes JR, Freemantle N, Mason J, Eccles M, Boynton J. Selective serotonin reuptake inhibitors (SSRIs) versus other antidepressants for depression - Geddes, JR– 1999| Cochrane Library. [cited 2025 Jan 2]; Available from: https://www.cochranelibrary.com/cdsr/doi/https://doi.org/10.1002/14651858.CD001851/abstract
McCloskey DJ, Postolache TT, Vittone BJ, Nghiem KL, Monsale JL, Wesley RA, et al. Selective serotonin reuptake inhibitors: measurement of effect on platelet function. Translational Res. 2008;151(3):168–72.
Weinrieb RM, Auriacombe M, Lynch KG, Lewis JD. Selective serotonin re-uptake inhibitors and the risk of bleeding. Exp Opin Drug Saf. 2005;4(2):337–44.
Dalton SO, Johansen C, Mellemkjær L, Sørensen HT, Nørgård B, Olsen JH. Use of selective serotonin reuptake inhibitors and risk of upper Gastrointestinal tract bleeding: A Population-Based cohort study. Arch Intern Med. 2003;163(1):59–64.
Article CAS PubMed Google Scholar
Douros A, Ades M, Renoux C. Risk of intracranial hemorrhage associated with the use of antidepressants inhibiting serotonin reuptake: A systematic review. CNS Drugs. 2018;32(4):321–34.
Article CAS PubMed Google Scholar
Mahdanian AA, Rej S, Bacon SL, Ozdin D, Lavoie KL, Looper K. Serotonergic antidepressants and perioperative bleeding risk: a systematic review. Exp Opin Drug Saf. 2014;13(6):695–704.
Mansour A, Pearce M, Johnson B, Sey MSL, Oda N, Collegala N et al. Which patients taking SSRIs are at greatest risk of bleeding?| EBSCOhost [Internet]. Vol. 55. 2006 [cited 2025 Jan 2]. p. 206. Available from: https://openurl.ebsco.com/contentitem/gcd:20093348?sid=ebsco:plink:crawler&id=ebsco:gcd:20093348
Calvi A, Fischetti I, Verzicco I, Belvederi Murri M, Zanetidou S, Volpi R et al. Antidepressant Drugs Effects on Blood Pressure. Front Cardiovasc Med [Internet]. 2021 Aug 3 [cited 2025 Jan 2];8. Available from: https://www.frontiersin.org/journals/cardiovascular-medicine/articles/https://doi.org/10.3389/fcvm.2021.704281/full
Hou R, Ye G, Liu Y, Chen X, Pan M, Zhu F, Brain, et al. Behav Immun. 2019;81:105–10.
Halperin D, Reber G. Influence of antidepressants on hemostasis. Dialog Clin Neurosci. 2007;9(1):47–59.
Bixby AL, VandenBerg A, Bostwick JR. Clinical management of bleeding risk with antidepressants. Ann Pharmacother. 2019;53(2):186–94.
Article CAS PubMed Google Scholar
Targownik LE, Bolton JM, Metge CJ, Leung S, Sareen J. Selective serotonin reuptake inhibitors are associated with a modest increase in the risk of upper Gastrointestinal bleeding. Official J Am Coll Gastroenterol| ACG. 2009;104(6):1475.
Gill H, Gill B, El-Halabi S, Chen-Li D, Lipsitz O, Rosenblat JD, et al. Antidepressant medications and weight change: A narrative review. Obes (Silver Spring). 2020;28(11):2064–72.
Mayo Clinic [Internet]. 2025 [cited 2025 Jan 6]. Antidepressants: Selecting one that’s right for you. Available from: https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20046273
Cowen PJ. SSRIs in the treatment of depression: A Pharmacological CUL-DE-SAC? Curr Top Behav Neurosci. 2024;66:1–19.
Murphy SE, Capitão LP, Giles SLC, Cowen PJ, Stringaris A, Harmer CJ. The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action. Lancet Psychiatry. 2021;8(9):824–35.
Sansone RA, Sansone LA. Serotonin norepinephrine reuptake inhibitors: A Pharmacological comparison. Innov Clin Neurosci. 2014;11(3–4):37–42.
PubMed PubMed Central Google Scholar
DeMartini J, Patel G, Fancher TL. Generalized anxiety disorder. Ann Intern Med. 2019;170(7):ITC49–64.
Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) [Internet]. 2025 [cited 2025 Jan 6]. Available from: https://elsevier.health/en-US/preview/serotonin-norepinephrine-reuptake-inhibitors-snris
Moraczewski J, Awosika AO, Aedma KK. Tricyclic Antidepressants. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2025 Jan 6]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK557791/
Kovich H, Kim W, Quaste AM. Pharmacologic treatment of depression. Am Fam Physician. 2023;107(2):173–81.
Punay NC, Couch JR. Antidepressants in the treatment of migraine headache. Curr Pain Headache Rep. 2003;7(1):51–4.
Sheffler ZM, Patel P, Abdijadid S. Antidepressants. In: StatPearls [Internet] [Internet]. StatPearls Publishing; 2023 [cited 2025 Jan 6]. Available from: https://www.ncbi.nlm.nih.gov/sites/books/NBK538182/
Chu A, Wadhwa R. Selective serotonin reuptake inhibitors. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2025 Jan 6]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK554406/
Schlienger RG, Meier CR. Effect of selective serotonin reuptake inhibitors on platelet activation: can they prevent acute myocardial infarction? Am J Cardiovasc Drugs. 2003;3(3):149–62.
Article CAS PubMed Google Scholar
Duerschmied D, Bode C. [The role of serotonin in haemostasis]. Hamostaseologie. 2009;29(4):356–9.
Article CAS PubMed Google Scholar
Grech J, Chan MV, Ochin C, Lachapelle A, Thibord F, Schneider Z, et al. Serotonin-Affecting antidepressant use in relation to platelet reactivity. Clin Pharmacol Ther. 2022;111(4):909–18.
Article CAS PubMed PubMed Central Google Scholar
Zeiss R, Connemann BJ, Schönfeldt-Lecuona C, Gahr M. Risk of bleeding associated with antidepressants: impact of causality assessment and competition Bias on signal detection. Front Psychiatry. 2021;12:727687.
Article PubMed PubMed Central Google Scholar
Rahman AA, Platt RW, Beradid S, Boivin JF, Rej S, Renoux C. Concomitant use of selective serotonin reuptake inhibitors with oral anticoagulants and risk of major bleeding. JAMA Netw Open. 2024;7(3):e243208.
Article PubMed PubMed Central Google Scholar
GGC Medicines. SSRIs/SNRIs - Risk of bleeding [Internet]. 2025 [cited 2025 Jan 6]. Available from: https://ggcmedicines.org.uk/blog/medicines-update/ssris-snris-risk-of-bleeding/
Cochran KA, Cavallari LH, Shapiro NL, Bishop JR. Bleeding incidence with concomitant use of antidepressants and warfarin. Ther Drug Monit. 2011;33(4):433–8.
Article CAS PubMed PubMed Central Google Scholar
Mayo Clinic [Internet]. 2025 [cited 2025 Jan 6]. Antidepressants that don’t fit into other classes. Available from: https://www.mayoclinic.org/diseases-conditions/depression/in-depth/atypical-antidepressants/art-20048208
Mercer SW, Payne RA, Nicholl BI, Morrison J. Risk of intracranial haemorrhage linked to co-treatment with antidepressants and NSAIDs. BMJ [Internet]. 2015;351. Available from: https://www.bmj.com/content/351/bmj.h3745
Shin JY, Park MJ, Lee SH, Choi SH, Kim MH, Choi NK, et al. Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal anti-inflammatory drugs: nationwide propensity score matched study. BMJ. 2015;351:h3517.
Article PubMed PubMed Central Google Scholar
Nochaiwong S, Ruengorn C, Awiphan R, Chai-Adisaksopha C, Tantraworasin A, Phosuya C, et al. Use of serotonin reuptake inhibitor antidepressants and the risk of bleeding complications in patients on anticoagulant or antiplatelet agents: a systematic review and meta-analysis. Ann Med. 2021;54(1):80–97.
Article PubMed Central Google Scholar
Yuet WC, Derasari D, Sivoravong J, Mason D, Jann M. Selective serotonin reuptake inhibitor use and risk of Gastrointestinal and intracranial bleeding. J Osteopath Med. 2019;119(2):102–11.
Carvajal A, Ortega S, Del Olmo L, Vidal X, Aguirre C, Ruiz B, et al. Selective serotonin reuptake inhibitors and Gastrointestinal bleeding: A Case-Control study. PLoS ONE. 2011;6(5):e19819.
Article CAS PubMed PubMed Central Google Scholar
Axelsson M, Tukukino C, Parodi López N, Wallerstedt S. Bleeding in patients on concurrent treatment with a selective serotonin reuptake inhibitor (SSRI) and low-dose acetylsalicylic acid (ASA) compared with SSRI or low-dose ASA alone—A systematic review and meta-analysis. Br J Clin Pharmacol. 2024;90(4):916–32.
de Abajo FJ. Effects of selective serotonin reuptake inhibitors on platelet function: mechanisms, clinical outcomes and implications for use in elderly patients. Drugs Aging. 2011;28(5):345–67.
Hergovich N, Aigner M, Eichler HG, Entlicher J, Drucker C, Jilma B. Paroxetine decreases platelet serotonin storage and platelet function in human beings. Clin Pharmacol Ther. 2000;68(4):435–42.
Article CAS PubMed Google Scholar
Reikvam AG, Hustad S, Reikvam H, Apelseth TO, Nepstad I, Hervig TA. The effects of selective serotonin reuptake inhibitors on platelet function in whole blood and platelet concentrates. Platelets. 2012;23(4):299–308.
Comments (0)