Hjartaker A, Langseth H, Weiderpass E (2008) Obesity and diabetes epidemics: cancer repercussions. Adv Exp Med Biol 630:72–93

Article  PubMed  Google Scholar 

Centers for Disease Control and Prevention (2020) National diabetes statistics report. Centers for Disease Control and Prevention, U.S. Dept of Health and Human Services. https://www.cdc.gov/diabetes/php/dataresearch/index.html

Savulescu-Fiedler I, Mihalcea R, Dragosloveanu S, Scheau C, Baz RO, Caruntu A, Scheau AE, Caruntu C, Benea SN (2024) The Interplay between Obesity and Inflammation. Life 14(7):856

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chobot A et al (2018) Obesity and diabetes-Not only a simple link between two epidemics. Diabetes Metab Res Rev 34(7):e3042

Article  PubMed  PubMed Central  Google Scholar 

Colosia AD, Palencia R, Khan S (2013) Prevalence of hypertension and obesity in patients with type 2 diabetes mellitus in observational studies: a systematic literature review. Diabetes Metab Syndr Obes 6:327–338

Article  PubMed  PubMed Central  Google Scholar 

Gallagher EJ, LeRoith D (2020) Hyperinsulinaemia in cancer. Nat Rev Cancer 20(11):629–644

Article  CAS  PubMed  Google Scholar 

Zhang AMY et al (2021) Hyperinsulinemia in obesity, inflammation, and cancer. Diabetes Metab J 45(3):285–311

Article  PubMed  PubMed Central  Google Scholar 

Sudan SK et al (2024) Obesity and early-onset breast cancer and specific molecular subtype diagnosis in black and white women: nimhd social epigenomics program. JAMA Netw Open 7(7):e2421846

Article  PubMed  PubMed Central  Google Scholar 

Milani I et al (2024) The intricate relationship between obesity, type 2 diabetes and female breast cancer: A retrospective study of 335 women. Obes Sci Pract 10(4):e786

Article  PubMed  PubMed Central  Google Scholar 

Alsheikh HAM et al (2021) Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seeding. Cancer Lett 517:24–34

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674

Article  CAS  PubMed  Google Scholar 

Garcia C, Andersen CJ, Blesso CN (2023) The role of lipids in the regulation of immune responses. Nutrients 15(18):3899

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nicholas DA, Proctor EA, Agrawal M, Belkina AC, Van Nostrand SC, Panneerseelan-Bharath L, Jones AR, Ip BC, Zhu M, Cacicedo JM, Habib C (2019) Fatty acid metabolites combine with reduced β oxidation to activate Th17 inflammation in human type 2 diabetes. Cell Metabol 30(3):447–61

Article  CAS  Google Scholar 

Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH (2020) Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity. Cell. 183(7):1848–66

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poloz Y, Stambolic V (2015) Obesity and cancer, a case for insulin signaling. Cell Death Dis 6(12):e2037

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown KA (2021) Metabolic pathways in obesity-related breast cancer. Nat Rev Endocrinol 17(6):350–363

Article  PubMed  PubMed Central  Google Scholar 

Hopkins BD, Goncalves MD, Cantley LC (2016) Obesity and cancer mechanisms: cancer metabolism. J Clin Oncol 34(35):4277–4283

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salas JR, Clark PM (2022) Signaling pathways that drive (18)F-FDG accumulation in cancer. J Nucl Med 63(5):659–663

Article  CAS  PubMed  Google Scholar 

Piening A et al (2024) Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk. Nat Commun 15(1):2835

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miracle CE et al (2024) Mechanisms by which obesity regulates inflammation and anti-tumor immunity in cancer. Biochem Biophys Res Commun 733:150437

Article  CAS  PubMed  Google Scholar 

Li P et al (2024) The mediating role of chronic low-grade inflammation participation in the relationship between obesity and type 2 diabetes: findings from the NHANES. BMC Endocr Disord 24(1):130

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu YZ, Wang YX, Jiang CL (2017) Inflammation: the common pathway of stress-related diseases. Front Hum Neurosci 11:316

Article  PubMed  PubMed Central  Google Scholar 

Berbudi A et al (2020) Type 2 diabetes and its impact on the immune system. Curr Diabetes Rev 16(5):442–449

PubMed  PubMed Central  Google Scholar 

Shi C et al (2014) IL-6 and TNF-alpha induced obesity-related inflammatory response through transcriptional regulation of miR-146b. J Interferon Cytokine Res 34(5):342–348

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trayhurn P, Wood IS (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92(3):347–355

Article  CAS  PubMed  Google Scholar 

Chawla A, Nguyen KD, Goh YP (2011) Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol 11(11):738–749

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JH et al (2019) Relationship between natural killer cell activity and glucose control in patients with type 2 diabetes and prediabetes. J Diabetes Investig 10(5):1223–1228

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berrou J et al (2013) Natural killer cell function, an important target for infection and tumor protection, is impaired in type 2 diabetes. PLoS ONE 8(4):e62418

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez N et al (2016) Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice. Microbes Infect 18(10):649–655

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ley K et al (2007) Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 7(9):678–689

Article  CAS  PubMed  Google Scholar 

McCarthy CE et al (2020) In vivo Imaging Technologies to Monitor the Immune System. Front Immunol 11:1067

Article  CAS  PubMed  PubMed Central  Google Scholar