Marx CK, Hertel TC, Pietzsch M (2008) Random mutagenesis of a recombinant microbial transglutaminase for the generation of thermostable and heat-sensitive variants. J Biotechnol 136(3–4):156–162. https://doi.org/10.1016/j.jbiotec.2008.06.005

Article  PubMed  CAS  Google Scholar 

Yokoyama K, Suzuki M, Kawashima I, Karasawa K, Nojima S, Enomoto T, Tai T, Suzuki A, Setaka M (1997) Changes in composition of newly synthesized sphingolipids of HeLa cells during the cell cycle - Suppression of sphingomyelin and higher-glycosphingolipid synthesis and accumulation of ceramide and glucosylceramide in mitotic cells. Eur J Biochem 249(2):450–455. https://doi.org/10.1111/j.1432-1033.1997.00450.x

Article  PubMed  CAS  Google Scholar 

Lerner A, Ramesh A, Matthias T (2020) The temperature and ph repertoire of the transglutaminase family is expanding. FEBS Open Bio 10(4):492–494. https://doi.org/10.1002/2211-5463.12839

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lerner A, Benzvi C, Vojdani A (2025) The frequently used industrial food process additive, microbial transglutaminase: boon or bane. Nutr Rev 83(3):1286–1294. https://doi.org/10.1093/nutrit/nuae087

Article  Google Scholar 

Lerner A, Benzvi C, Vojdani A (2023) Cross-reactivity and sequence similarity between microbial transglutaminase and human tissue antigens. Sci Rep 13(1):17526. https://doi.org/10.1038/s41598-023-44452-5

Article  PubMed  PubMed Central  CAS  Google Scholar 

Khushboo M, Thakur M, Kumar P, Rajput D, Yadav V, Dhaka N, Shukla R, Dubey KK (2023) Genome-guided approaches and evaluation of the strategies to influence bioprocessing assisted morphological engineering of Streptomyces cell factories. Bioresource Technol. https://doi.org/10.1016/j.biortech.2023.128836

Article  Google Scholar 

Suryadi H, Irianti MI, Septiarini TH (2022) Methods of random mutagenesis of Aspergillus strain for increasing kojic acid production. Curr Pharm Biotechnol 23(4):486–494. https://doi.org/10.2174/1389201022666210615125004

Article  PubMed  CAS  Google Scholar 

Gao X, Liu E, Yin Y, Yang L, Huang Q, Chen S, Ho C-T (2020) Enhancing activities of salt-tolerant proteases secreted by Aspergillus oryzae using atmospheric and room-temperature plasma mutagenesis. J Agric Food Chem 68(9):2757–2764. https://doi.org/10.1021/acs.jafc.9b08116

Article  PubMed  CAS  Google Scholar 

Zhao L, Wang J, Sheng X, Li S, Yan W, Qian J, Zhang J, Raghavan V (2023) Non-thermal plasma inhibited the growth and aflatoxins production of Aspergillus flavus, degraded aflatoxin B1 and its potential mechanisms. Chem Eng J. https://doi.org/10.1016/j.cej.2023.146017

Article  PubMed  PubMed Central  Google Scholar 

Zhao LL, Zheng JR, Yan WJ, Qian J, Zhang JH, Wang J, Sheng XW, Raghavan V, Yang XH, Han YX, Cao TT, Chen YT (2025) Combined high voltage atmospheric cold plasma and ultraviolet-cold plasma inhibited Aspergillus flavus growth and improved physicochemical properties of protein in peanuts. Food Chem. https://doi.org/10.1016/j.foodchem.2024.141607

Article  PubMed  Google Scholar 

Li X, Liu R, Li J, Chang M, Liu Y, Jin Q, Wang X (2015) Enhanced arachidonic acid production from Mortierella alpina combining atmospheric and room temperature plasma (ARTP) and diethyl sulfate treatments. Bioresour Technol 177:134–140. https://doi.org/10.1016/j.biortech.2014.11.051

Article  PubMed  CAS  Google Scholar 

Lv X-A, Jin Y-Y, Li Y-D, Zhang H, Liang X-L (2013) Genome shuffling of Streptomyces viridochromogenes for improved production of avilamycin. Appl Microbiol Biotechnol 97(2):641–648. https://doi.org/10.1007/s00253-012-4322-7

Article  PubMed  CAS  Google Scholar 

Zhang Q, Feng X, Chen X, Lu K (2020) Mix design for recycled aggregate pervious concrete based on response surface methodology. Constr Build Mater. https://doi.org/10.1016/j.conbuildmat.2020.119776

Article  Google Scholar 

Liu Y, Gong H, Shi C, Yuan H, Zuo X, Chang Y, Li X (2022) Modeling and optimization of the hydrolysis and acidification via liquid fraction of digestate from corn straw by response surface methodology and artificial neural network. J Clean Prod. https://doi.org/10.1016/j.jclepro.2022.132241

Article  PubMed  PubMed Central  Google Scholar 

Singh V, Khan M, Khan S, Tripathi CKM (2009) Optimization of actinomycin V production by Streptomyces triostinicus using artificial neural network and genetic algorithm. Appl Microbiol Biotechnol 82(2):379–385. https://doi.org/10.1007/s00253-008-1828-0

Article  PubMed  CAS  Google Scholar 

Chang T, Bian L, Li G, Zhang C (2025) Action of microbial transglutaminase (MTGase) on the processing properties of glutinous rice flour and the quality attributes of sweet dumplings and in vitro digestion. Food Chem. https://doi.org/10.1016/j.foodchem.2024.140992

Article  PubMed  Google Scholar 

Zhang L, Sun L, Yi H, Wang S, Han J, Liu N, Zhang S, Zhang L (2019) Comparative proteome analysis of Streptomyces mobaraensis under MgCl2 stress shows proteins modulating differentiation and transglutaminase biosynthesis. Food Res Int 121:622–632. https://doi.org/10.1016/j.foodres.2018.12.027

Article  PubMed  CAS  Google Scholar 

Yin X, Li Y, Zhou J, Rao S, Du G, Chen J, Liu S (2021) Enhanced production of transglutaminase in Streptomyces mobaraensis through random mutagenesis and site-directed genetic modification. J Agric Food Chem 69(10):3144–3153. https://doi.org/10.1021/acs.jafc.1c00645

Article  PubMed  CAS  Google Scholar 

Hirano S, Kato JY, Ohnishi Y, Horinouchi S (2006) Control of the Streptomyces subtilisin inhibitor gene by AdpA in the A-factor regulatory cascade in Streptomyces griseus. J Bacteriol 188(17):6207–6216. https://doi.org/10.1128/jb.00662-06

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang L, Zhang L, Han X, Du M, Zhang Y, Feng Z, Yi H, Zhang Y (2012) Enhancement of transglutaminase production in Streptomyces mobaraensis as achieved by treatment with excessive MgCl2. Appl Microbiol Biotechnol 93(6):2335–2343. https://doi.org/10.1007/s00253-011-3790-5

Article  PubMed  CAS  Google Scholar 

Zhang XT, Zhang QG, Li YM, Zhang H (2023) Modeling and optimization of photo-fermentation biohydrogen production from co-substrates basing on response surface methodology and artificial neural network integrated genetic algorithm. Bioresour Technol. https://doi.org/10.1016/j.biortech.2023.128789

Article  PubMed  PubMed Central  Google Scholar 

Laroussi M (2005) Low temperature plasma-based sterilization: overview and state-of-the-art. Plasma Process Polym 2(5):391–400. https://doi.org/10.1002/ppap.200400078

Article  CAS  Google Scholar 

Ren F, Chen L, Xiong SL, Tong QY (2017) Enhanced acarbose production by Streptomyces M37 using a two-stage fermentation strategy. Plos one. https://doi.org/10.1371/journal.pone.0166985

Article  PubMed  PubMed Central  Google Scholar 

Yen HW, Hsiao HP, Chen LJ (2013) The enhancement of rapamycin production using Streptomyces hygroscopicus through a simple ph-shifted control. J Taiwan Inst Chem Eng 44(5):743–747. https://doi.org/10.1016/j.jtice.2013.01.025

Article  CAS  Google Scholar 

Chater KF, Biro S, Lee KJ, Palmer T, Schrempf H (2010) The complex extracellular biology of Streptomyces. FEMS Microbiol Rev 34(2):171–198. https://doi.org/10.1111/j.1574-6976.2009.00206.x

Article  PubMed  CAS  Google Scholar 

Chen K, Zhang D, Liu S, Wang NS, Wang M, Du G, Chen J (2013) Improvement of transglutaminase production by extending differentiation phase of Streptomyces hygroscopicus: mechanism and application. Appl Microbiol Biotechnol 97(17):7711–7719. https://doi.org/10.1007/s00253-012-4614-y

Article  PubMed  CAS  Google Scholar 

Zotzel J, Keller P, Fuchsbauer HL (2003) Transglutaminase from Streptomyces mobaraensis is activated by an endogenous metalloprotease. Eur J Biochem 270(15):3214–3222. https://doi.org/10.1046/j.1432-1033.2003.03703.x

Article  PubMed  CAS  Google Scholar 

Yin X, Rao S, Zhou J, Du G, Chen J, Liu S (2022) Improved productivity of Streptomyces mobaraensis transglutaminase by regulating zymogen activation. Front Bioeng Biotechnol. https://doi.org/10.3389/fbioe.2022.878795