Chitosan/β-Glycerophosphate Thermosensitive Aerosol Hydrogel as an Innovative Medical Device for Rapid Hemostasis in Emergency Related Physical Trauma: A Comprehensive Review

Adi Yunanto R. Faiza, Iswatiningtyas N, Rifatun Nisak E, Keperawatan Gawat Darurat dan Kritis D, Keperawatan F, Jember U, Keperawatan Medikal D (2024) DEDIKASI SAINTEK: Jurnal Pengabdian Masyarakat Optimalisasi Keterampilan Penanganan Gawat Darurat Perdarahan Melalui Metode Simulasi Kasus pada Remaja (Optimalization of emergency handling skills for bleeding through the case simulation method for adolescents) 3:185–98. https://doi.org/10.58545/djpm.v2i3.288

WHO. Injuries and violence; 2024. https://www.who.int/News-Room/Fact-Sheets/Detail/Injuries-and-Violence. Accessed 7 Aug 2025.

Pfeifer R, Tarkin IS, Rocos B, Pape HC. Patterns of mortality and causes of death in polytrauma patients-has anything changed? Injury. 2009;40(9):907–11. https://doi.org/10.1016/j.injury.2009.05.006.

Article  PubMed  Google Scholar 

Sauaia A, Moore FA, Moore EE. Postinjury inflammation and organ dysfunction. Crit Care Clin 2017;33(1):167–191. https://doi.org/10.1016/j.ccc.2016.08.006

Chapter  Google Scholar 

Rahmawati EY, Primasari Y, Rinestaelsa UA. Pemberdayaan Kader RW 05, Kelurahan Rambutan, Kecamatan Ciracas, Jakarta Timur dengan Pemberian Edukasi dan Pelatihan untuk Meningkatkan Kemampuan Penanganan Kondisi Gawat Darurat. Jurnal Inovasi Pengabdian Dan Pemberdayaan Masyarakat. 2022;2(2):105–12. https://doi.org/10.54082/jippm.33.

Article  Google Scholar 

Nicholl J, West J, Goodacre S, Turner J. The relationship between distance to hospital and patient mortality in emergencies: an observational study. Emergency Medicine Journal: EMJ. 2007;24(9):665–8. https://doi.org/10.1136/emj.2007.047654.

Article  PubMed  PubMed Central  Google Scholar 

Bulger EM, Snyder D, Schoelles K, Gotschall C, Dawson D, Lang E, Sanddal ND, Butler FK, Fallat M, Taillac P, White L, Salomone JP, Seifarth W, Betzner MJ, Johannigman J, McSwain N. An evidence-based prehospital guideline for external hemorrhage control: American college of surgeons committee on trauma. Prehosp Emerg Care. 2014;18(2):163–73. https://doi.org/10.3109/10903127.2014.896962.

Article  PubMed  Google Scholar 

Sood A, Granick MS, Tomaselli NL. Wound dressings and comparative effectiveness data. Adv Wound Care. 2014;3(8):511–29. https://doi.org/10.1089/wound.2012.0401.

Article  Google Scholar 

Galante JM. Using tourniquets to stop bleeding. JAMA. 2017;317(14):1490. https://doi.org/10.1001/jama.2015.8581.

Article  PubMed  Google Scholar 

Alcelik I, Pollock RD, Sukeik M, Bettany-Saltikov J, Armstrong PM, Fismer P. A comparison of outcomes with and without a tourniquet in total knee arthroplasty. A systematic review and meta-analysis of randomized controlled trials. J Arthroplasty. 2012;27(3):331–40. https://doi.org/10.1016/j.arth.2011.04.046.

Article  PubMed  Google Scholar 

Palmer SH, Graham G. Tourniquet-induced rhabdomyolysis after total knee replacement. Ann R Coll Surg Engl. 1994;76(6):416–7.

PubMed  PubMed Central  CAS  Google Scholar 

Parvizi J, Diaz-Ledezma C, Parvizi NJ, Surgery O, Diaz-Ledezma NC. Total knee replacement with the use of a tourniquet. Bone Joint J. 2013;95(11):133–7. https://doi.org/10.1302/0301-620X.95B11.

Article  PubMed  Google Scholar 

Omo QG, Hassan NE. Biomedical waste management and their effects on the Environment: A review. World J Adv Eng Technol Sci. 2024;11(1):86–95. https://doi.org/10.30574/wjaets.2024.11.1.0020.

Article  Google Scholar 

Kauvar DS, Lefering R, Wade CE. Impact of hemorrhage on trauma outcome: An overview of epidemiology, clinical presentations, and therapeutic considerations. Journal of Trauma - Injury, Infection and Critical Care. 2006;60(6 SUPPL):S3–11. https://doi.org/10.1097/01.ta.0000199961.02677.19.

Huang L, Liu G, Kaye A, Liu H. Advances in topical hemostatic agent therapies: a comprehensive update. Adv Ther. 2020;37:4132–48. https://doi.org/10.6084/m9.figshare.12767606.

Article  PubMed  CAS  Google Scholar 

Shina A, Lipsky AM, Nadler R, Levi M, Benov A, Ran Y, Yitzhak A, Glassberg E. Prehospital use of hemostatic dressings by the Israel defense forces medical corps: A case series of 122 patients. J Trauma Acute Care Surg. 2015;79(4):S204–9. https://doi.org/10.1097/TA.0000000000000720.

Article  PubMed  CAS  Google Scholar 

Te Grotenhuis R, Van Grunsven PM, Heutz WMJM, Tan ECTH. Prehospital use of hemostatic dressings in emergency medical services in the Netherlands: A prospective study of 66 cases. Injury. 2016;47(5):1007–11. https://doi.org/10.1016/j.injury.2016.01.005.

Article  Google Scholar 

Jamali B, Nouri S, Amidi S. Local and systemic hemostatic agents: a comprehensive review. Cureus. 2024. https://doi.org/10.7759/cureus.72312.

Wichterle O, Lím D. Hydrophilic gels for biological use. Nature. 1960;185:117–8. https://doi.org/10.1038/185117a0.

Article  Google Scholar 

Winter GD. Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. Nature. 1962;193:293–4. https://doi.org/10.1038/193293a0.

Article  PubMed  CAS  Google Scholar 

Boateng JS, Matthews KH, Stevens HN, Eccleston GM. Wound healing dressings and drug delivery systems: a review. J Pharm Sci. 2008;97(8):2892–923. https://doi.org/10.1002/jps.21210.

Article  PubMed  CAS  Google Scholar 

Peppas NA, Hilt JZ, Khademhosseini A, Langer R. Hydrogels in biology and medicine: From molecular principles to bionanotechnology. J Biomed Mater Res. 2000;59(1):65–72. https://doi.org/10.1002/adma.200501612.

Article  CAS  Google Scholar 

Khor E, Lim LY. Implantable applications of chitin and chitosan. Biomaterials. 2003;24(13):2339–49. https://doi.org/10.1016/S0142-9612(03)00026-7.

Article  PubMed  CAS  Google Scholar 

Carrêlo H, Jiménez-Rosado M, Vieira T, Da Rosa RR, Perez-Puyana VM, Silva JC, Romero A, Borges JP, Soares PIP. A thermoresponsive injectable drug delivery system of chitosan/β-glycerophosphate with gellan gum/alginate microparticles. Int J Biol Macromol. 2024;271: 131981. https://doi.org/10.1016/j.ijbiomac.2024.131981.

Article  PubMed  CAS  Google Scholar 

Jayakumar R, Prabaharan M, Sudheesh Kumar PT, Nair SV, Tamura H. Biomaterials based on chitin and chitosan in wound dressing applications. Biotechnol Adv. 2011;29(3):322–37. https://doi.org/10.1016/j.biotechadv.2011.01.005.

Article  PubMed  CAS  Google Scholar 

Yu L, Tian Y, Ding Y, Chi Z, Liu C. Chitosan/β-glycerophosphate porous microsphere prepared by facile water-in-water emulsion as a topical hemostatic material. Int J Biol Macromol. 2024;277: 133683. https://doi.org/10.1016/j.ijbiomac.2024.133683.

Article  PubMed  CAS  Google Scholar 

Gupta R, Mohanty S, Verma D. Current status of hemostatic agents, their mechanism of action, and future directions. J Bioact Compat Polym. 2023;38(2):77–105. https://doi.org/10.1177/08839115221147935.

Article  Google Scholar 

Heemskerk JWM, Bevers EM, Lindhout T. Platelet activation and blood coagulation. Thromb Haemost. 2002;88(2):186–93.

PubMed  CAS  Google Scholar 

Chapin JC, Hajjar KA. Fibrinolysis and the control of blood coagulation. Blood Rev. 2015;29(1):17–24. https://doi.org/10.1016/j.blre.2014.09.003.

Article  PubMed  CAS  Google Scholar 

De Pablo-Moreno JA, Serrano LJ, Revuelta L, Sánchez MJ, Liras A. The vascular endothelium and coagulation: homeostasis, disease, and treatment, with a focus on the Von Willebrand factor and factors VIII and V. Int J Mol Sci. 2022;23(15):8283. https://doi.org/10.3390/ijms23158283.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Versteeg HH, Heemskerk JWM, Levi M, Reitsma PH. New fundamentals in hemostasis. Physiol Rev. 2013;93(1):327–58. https://doi.org/10.1152/physrev.00016.2011.

Article  PubMed  CAS  Google Scholar 

MacCallum PK. Markers of hemostasis and systemic inflammation in heart disease and atherosclerosis in smokers. Proc Am Thorac Soc. 2005;2(1):34–43. https://doi.org/10.1513/pats.200406-036MS.

Article  PubMed  CAS  Google Scholar 

Caspers M, Maegele M, Fröhlich M. Current strategies for hemostatic control in acute trauma hemorrhage and trauma-induced coagulopathy. Expert Rev Hematol. 2018;11(12):987–95. https://doi.org/10.1080/17474086.2018.1548929.

Article  PubMed  CAS  Google Scholar 

Mikhail J. The trauma triad of death: hypothermia, acidosis, and coagulopathy. AACN Clin Issues. 1999;10(1):85–94.

Article  PubMed 

Comments (0)

No login
gif