The 2025 Santa Fe Bone Symposium (SFBS) was a combined in-person and virtual “hybrid” meeting based in Santa Fe, New Mexico, USA, on August 8-9, 2025. There were an equivalent number of in-person and remote attendees from throughout the USA and other countries. The SFBS was immediately preceded, on August 6-7, 2025, by the 2-day Endocrine Fellows Foundation-Santa Fe Bone Symposium Workshop on Metabolic Bone Diseases. This preceptorship included basic bone biology, osteoporosis, parathyroid and rare bone diseases. Most of the fellows attended the SFBS, for a total of 4 days of non-stop education in skeletal health. The topics covered at the SFBS included controversies and consensus in the use of dual-energy X-ray absorptiometry; management of osteoporosis medication side-effects; lessons learned from bone biopsies; osteoporosis in men and premenopausal women; update on treatment of rare bone diseases; parathyroid hormone and skeletal health; periprosthetic fractures; update on Bone Health ECHO; and much more. Ancillary events addressed issues such as bone health through the menopause transition, hypophosphatasia, X-linked hypophosphatemia, and osteoanabolic therapy for postmenopausal women with osteoporosis. This report of the proceedings of the 2025 SFBS summarizes the highlights and clinical insights of the plenary presentations.

Bone biopsy

ECHO

Osteoporosis

Periprosthetic fractures

Parathyroid

© 2025 The Author(s). Published by Elsevier Inc. on behalf of The International Society for Clinical Densitometry.