Authors Uzma Firdous Department of Physiology, University of Karachi Mehir-un-nisa Iqbal Department of Physiology, University of Karachi DOI: https://doi.org/10.58397/p4r8j564 Keywords: PCOS, Testosterone, Insulin, T. stocksianum, O. basilicum Abstract

Objectives:  The aim of the current investigation is to evaluate and compare the effect of traditional medicinal plants; Teucrium stocksianum and Ocimum basilicum on metabolic and reproductive dysfunctions associated with PCOS.

Methods: This experimental study comprised of Group I (the negative control group), received sesame oil (vehicle), Group II (the positive control group) subcutaneously received testosterone (10 mg/kg bw), Group III (the T. stocksianum alone group) orally received T. stocksianum extract (500mg/Kg bw), Group IV (the PCOS and T. stocksianum group) received 6 week administration of testosterone followed by  T. stocksianum for 4 weeks, Group V (the O. basilicum alone group) orally received O. basilicum extract  (300mg/Kg bw), and Group VI (the PCOS and O. basilicum group), received testosterone for the first 6 weeks followed by O. basilicum extract for the next 4 weeks. At the end of the study, ovarian and metabolic markers were assessed in the blood samples of the experimental rats.

Results: The induction of T. stocksianum and O. basilicum in PCOS induced rats led to significantly improved levels of fasting plasma glucose, testosterone, Luteinizing Hormone (LH), Follicle stimulating hormone (FSH), Cholesterol, Low-density lipoprotein (LDL) and High-density lipoprotein (HDL) levels in both groups.  Meanwhile, in T. stocksianum group, Insulin and Insulin like growth factor binding protein-1 (IGFBP-1) whereas in O. basilicum group, Progesterone and Triglycerides levels were found to be significantly altered. No other significant changes were observed in the levels of Insulin like growth factor (IGF-1), and estrogen in both groups.

Conclusion: The findings of the current investigation underscored the potential of T. stocksianum and O. basilicum as adjunctive therapies in addressing the complications of PCOS, attributed to their significant impact on the biochemical markers of PCOS.

Author Biographies

Uzma Firdous, Department of Physiology, University of Karachi

LECTURER (ENROLLED IN PHD PROGRAMME)

DEPARTMENT OF PHYSIOLOGY

UNIVERSITY OF KARACHI

Mehir-un-nisa Iqbal, Department of Physiology, University of Karachi

Associate Professor

Endocrinology Unit Incharge

Department of Physiology

University of Karachi

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