Volume 114, Issue 3, March 2026, 117209Author links open overlay panelShuma Tsuji a, Shinnosuke Fukushima b c, Kazuyoshi Gotoh a, Koji Iio d, Mayu Sato e, Yasurou Inoue e, Sayaka Sakita f, Tomoko Fudeyasu g, Fumio Otsuka c h, Hideharu Hagiya c hShow moreHighlights•

Non-IMP type CPE isolates identified in Japan were investigated.

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Four blaNDM (NDM-1, NDM-5) and one blaKPC-2 were identified.

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Plasmid analysis showed homology to those found in other countries.

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Two patients lacked travel history, suggesting local silent transmission.

Abstract

We investigated the genetic characteristics of non-IMP type carbapenemase-producing Enterobacterales isolates detected in Japan. The isolates were found to carry diverse plasmids with high sequence similarity to those previously reported in other countries, underscoring the critical imperative for comprehensive nationwide epidemiological surveillance for the silent pandemic of the nightmare pathogen.

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Antimicrobial resistance

Carbapenemase-producing Enterobacterales

New Delhi metallo-β-lactamase

Klebsiella pneumoniae carbapenemase

Genomic surveillance

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