Dyslipidemias, characterized by abnormal blood lipid levels, are an important risk factor for cardiovascular diseases, the leading cause of mortality worldwide.1 In recent decades, changes in lifestyles and work patterns have contributed to the increased prevalence of these metabolic disorders, particularly in developing countries such as Peru.2

The work environment can significantly influence the lipid profile through various mechanisms. Occupational factors such as type of work, workplace sedentarism, and night shifts have been associated with metabolic alterations in several studies.3 Prolonged sitting time during the workday emerges as an independent risk factor for dyslipidemias, even in individuals who are physically active outside working hours.4 On the other hand, night work can alter the circadian rhythm, potentially affecting lipid metabolism through the deregulation of sleep and eating patterns.5

However, despite the growing evidence linking occupational factors with the risk of dyslipidemias,6, 7 few longitudinal studies have evaluated this relationship in low- and middle-income countries, where epidemiological and nutritional transitions have unique characteristics.

Considering this knowledge gap, the present study aims to: (1) determine the prevalence of dyslipidemias in a cohort of Peruvian workers; (2) calculate the incidence rate of hypertriglyceridemia, hypercholesterolemia, and combined dyslipidemias; and (3) assess the association between specific occupational variables (type of work, sitting time, and night work) and the development of these lipid alterations. The results will provide valuable information for the design of preventive and intervention strategies in the Peruvian workplace setting.