Colorectal Oncogenomics Group, Department of Clinical Pathology, Victorian Comprehensive Cancer Centre, The University of Melbourne, 305 Grattan Street, Parkville, VIC, 3010, Australia

Daniel D. Buchanan, Peter Georgeson, Romy Walker, Jihoon E. Joo, Mark Clendenning, Julia Como, Ryan O’Keeffe, Alysha Prisc, Yen Lin Chu, Christophe Rosty & Khalid Mahmood

Collaborative Centre for Genomic Cancer Medicine, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia

Daniel D. Buchanan, Peter Georgeson, Romy Walker, Jihoon E. Joo, Mark Clendenning, Julia Como, Ryan O’Keeffe, Alysha Prisc, Yen Lin Chu, Mark A. Jenkins, Christophe Rosty & Khalid Mahmood

Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Melbourne, VIC, 3000, Australia

Daniel D. Buchanan, Ingrid M. Winship & Finlay A. Macrae

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, 3053, Australia

Mark A. Jenkins

Envoi Specialist Pathologists, Brisbane, QLD, 4059, Australia

Christophe Rosty

University of Queensland, Brisbane, QLD, 4072, Australia

Christophe Rosty

Department of Medicine, The University of Melbourne, Parkville, VIC, 3000, Australia

Ingrid M. Winship

Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Parkville, VIC, 3000, Australia

Finlay A. Macrae

Cancer Genetics, Liverpool Hospital, Sydney, NSW, 2170, Australia

Emilia Ip

Department of Medicine, Western Sydney University, Sydney, NSW, 2170, Australia

Emilia Ip

Faculty of Medicine and Health, University of Sydney, Sydney, NSW, 2006, Australia

Rebecca Harris & Annabel Goodwin

Cancer Genetics Department, Royal Prince Alfred Hospital, Sydney, NSW, 2051, Australia

Rebecca Harris & Annabel Goodwin

Melbourne Bioinformatics, The University of Melbourne, Melbourne, VIC, 3053, Australia

Khalid Mahmood

DDB, AG and KM conceptualised and designed the study. DDB, PG, RW, JEJ, MC, JC, RO, AP, YLC, MJ, CR, IW, FM, EI, RH, AG and KM contributed to acquisition of data, including participant recruitment and acquisition of study materials, laboratory experiments and interpretation of data. KM performed the analysis of the data. KM and DDB drafted the manuscript, and all authors provided critical revision of the manuscript and approved the final submitted manuscript.