A novel, additive-free method has been developed for synthesizing 2,4-disubstituted oxazoles via thiourea-mediated cyclization of substituted 2-oxo-2-phenylethyl acetates. This approach utilizes readily available thiourea and α-acyloxy ketones under mild conditions with simple operation, offering a reliable and versatile route to diverse substituted oxazole derivatives.Substituted-oxazoles heterocycles often exhibit interesting bioactive properties, these structural motifs are important building blocks inhennoxazole, mirabegron, ritonavir, and dasatinib pharmacologically relevant molecules. [1][2][3][4] Beyond their biological relevance, substitutedoxazoles have wide application in agrochemicals, and materials science, and exhibit versatile utility as key components in fluorescent dyes and organic light-emitting diodes (OLEDs), effective ligands in transition-metal catalysis, functional polymers, corrosion inhibitors, chemical sensors, and highly adaptable building blocks in organic synthesi. [5][6] Recently, substantial research efforts have been devoted toward efficient synthetic routes to substituted oxazoles.