The global spread of the novel coronavirus (SARS-CoV-2) over the past few years has raised significant concerns across various populations. While initial attention primarily focused on the acute complications of COVID-19, it has become increasingly evident that the infection can result in serious long-term sequelae, particularly affecting the cardiovascular system in adults [[1], [2], [3]].
Compared to adults, children have generally experienced milder clinical courses and fewer acute complications. Although acute cardiovascular manifestations – such as myocarditis - have been reported in pediatric cases, they remain relatively uncommon [4]. However, recent research has begun to explore the potential long-term cardiovascular effects in children, especially among those presenting with symptoms such as chest pain, palpitations, or evidence of vascular and endothelial dysfunction following COVID-19 infection [5], [6]. Taking into account the possibility of subclinical or delayed cardiovascular involvement, there is a critical need to investigate cardiac function in children following SARS-CoV-2 infection. Such investigations are essential to inform appropriate follow-up and management strategies in this vulnerable population.
The aim of the present study is to assess both systolic and diastolic cardiac function in children up to one year after confirmed SARS-CoV-2 infection and to compare these findings with healthy, COVID-19 - naïve controls. By characterizing the incidence and nature of post-infectious cardiovascular involvement, this study seeks to support the development of evidence-based strategies for optimizing long-term cardiac health in pediatric patients.
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