TPE-based cationic AIEgen with large stokes shift enables detection of blood anti-coagulator heparin with high selectivity

Akhrass, R., Gillinov, M., Bakaeen, F., Akras, D., Cameron, S. J., Bishop, J., Kapadia, S., & Svensson, L. (2022). Emergency cardiac surgery in patients on oral anticoagulants and antiplatelet medications. Journal of Cardiac Surgery, 37, 214–222.

Article  PubMed  Google Scholar 

Gradolí, J., Vidal, V., Brady, A. J. B., & Facila, L. (2018). Anticoagulation in patients with ischaemic heart disease and peripheral arterial disease: Clinical implications of COMPASS study. European Cardiology Review, 13, 115–118.

Article  PubMed  PubMed Central  Google Scholar 

Qiu, M., Huang, S., Luo, C., Wu, Z., Liang, B., Huang, H., Ci, Z., Zhang, D., Han, L., & Lin, J. (2021). Pharmacological and clinical application of heparin progress: An essential drug for modern medicine. Biomedicine & Pharmacotherapy, 139, 111561.

Article  CAS  Google Scholar 

Hirsh, J., Anand, S. S., Halperin, J. L., & Fuster, V. (2001). Guide to anticoagulant therapy: Heparin. Circulation, 103, 2994–3018.

Article  CAS  PubMed  Google Scholar 

Roswell, R. O., Greet, B., Shah, S., Bernard, S., Milin, A., Lobach, I., Guo, Y., Radford, M. J., & Berger, J. S. (2016). Intravenous heparin dosing strategy in hospitalized patients with atrial dysrhythmias. Journal of Thrombosis and Thrombolysis, 42, 179–185.

Article  CAS  PubMed  Google Scholar 

Chuang, Y.-J., Swanson, R., Raja, S. M., & Olson, S. T. (2001). Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence: Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin*. Journal of Biological Chemistry, 276, 14961–14971.

Article  CAS  PubMed  Google Scholar 

Nand, S., Wong, W., Yuen, B., Yetter, A., Schmulbach, E., & Gross Fisher, S. (1997). Heparin-induced thrombocytopenia with thrombosis: Incidence, analysis of risk factors, and clinical outcomes in 108 consecutive patients treated at a single institution. American Journal of Hematology, 56, 12–16.

Article  CAS  PubMed  Google Scholar 

Ahmed, I., Majeed, A., & Powell, R. (2007). Heparin induced thrombocytopenia: Diagnosis and management update. Postgraduate Medical Journal, 83, 575–582.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nieuwenhuis, H. K., Albada, J., Banga, J. D., & Sixma, J. J. (1991). Identification of risk factors for bleeding during treatment of acute venous thromboembolism with heparin or low molecular weight heparin. Blood, 78, 2337–2343.

Article  CAS  PubMed  Google Scholar 

Ma, X., Kou, X., Xu, Y., Yang, D., & Miao, P. (2019). Colorimetric sensing strategy for heparin assay based on PDDA-induced aggregation of gold nanoparticles. Nanoscale Advances, 1, 486–489.

Article  CAS  PubMed  Google Scholar 

Cao, R., & Li, B. (2011). A simple and sensitive method for visual detection of heparin using positively-charged gold nanoparticles as colorimetric probes. Chemical Communications, 47, 2865–2867.

Article  CAS  PubMed  Google Scholar 

Miller, S. (2010). Naked-eye colorimetric analysis of heparin and its derivatives. Analytical Chemistry, 82, 1570–1570.

Article  CAS  Google Scholar 

Meng, F., Liang, W., Sun, H., Wu, L., Gong, X., & Miao, P. (2017). A peptide-based electrochemical biosensor for facile measurement of whole-blood heparin. ChemElectroChem, 4, 472–475.

Article  CAS  Google Scholar 

Zhou, X., Fang, S., Lin, L., Feng, H., Li, T., & Fang, L. (2025). Development of an electrochemical sensor for heparin utilizing PEDOT:PSS/AuNPs nanocomposites. Microchemical Journal, 215, 114480.

Article  CAS  Google Scholar 

Ouyang, Y., Yang, S., Wang, W., Cui, J., & Zhang, Z. (2025). State-of-the-art chromatographic and mass spectrometric techniques in heparin structural analysis. Journal of Pharmaceutical and Biomedical Analysis, 255, 116625.

Article  CAS  PubMed  Google Scholar 

Zhang, Z., Khan, N. M., Nunez, K. M., Chess, E. K., & Szabo, C. M. (2012). Complete monosaccharide analysis by high-performance anion-exchange chromatography with pulsed amperometric detection. Analytical Chemistry, 84, 4104–4110.

Article  CAS  PubMed  Google Scholar 

Sarkar, S., & Chakraborty, G. (2024). A label free ratiometric sensing of heparin using dynamic modulation of monomer–excimer equilibrium of coumarin 7. Journal of Molecular Liquids, 414, 126132.

Article  CAS  Google Scholar 

Liang, X., Nie, H., Yang, C., Wang, Z., Bai, J., & Yan, H. (2021). A cationic aggregation-induced emission luminogen for colorimetric and fluorimetric detection of heparin with a dual-read approach, stability and applicability in a 10% serum matrix. Journal of Molecular Liquids, 343, 117585.

Article  CAS  Google Scholar 

Kim, D., Lee, U., Bouffard, J., & Kim, Y. (2020). Glycosaminoglycan-induced emissive J-aggregate formation in a meso-ester BODIPY dye. Advanced Optical Materials, 8, 1902161.

Article  CAS  Google Scholar 

Chen, X.-T., Xiang, Y., Li, N., Song, P.-S., & Tong, A.-J. (2010). Fluorescence turn-on detection of protamine based on aggregation-induced emission enhancement characteristics of 4-(6′-carboxyl)hexyloxysalicylaldehyde azine. The Analyst, 135, 1098–1105.

Article  CAS  PubMed  Google Scholar 

Lan, J., Zou, H. Y., Wang, Q., Zeng, P., Li, Y. F., & Huang, C. Z. (2016). Sensitive and selective turn off-on fluorescence detection of heparin based on the energy transfer platform using the BSA-stabilized Au nanoclusters/amino-functionalized graphene oxide hybrids. Talanta, 161, 482–488.

Article  CAS  PubMed  Google Scholar 

Zheng, J., Ye, T., Chen, J., Xu, L., Ji, X., Yang, C., & He, Z. (2017). Highly sensitive fluorescence detection of heparin based on aggregation-induced emission of a tetraphenylethene derivative. Biosensors & Bioelectronics, 90, 245–250.

Article  CAS  Google Scholar 

Ma, L., Zhang, M., Yang, A., Wang, Q., Qu, F., Qu, F., & Kong, R.-M. (2018). Sensitive fluorescence detection of heparin based on self-assembly of mesoporous silica nanoparticle–gold nanoclusters with emission enhancement characteristics. The Analyst, 143, 5388–5394.

Article  CAS  PubMed  Google Scholar 

Zhou, Y., Jiang, H., Wang, Y., Zhao, S., Hu, L., & Zhang, Y. (2021). A cationic on–off fluorescent sensor with AIE properties for heparin and protamine detection. New Journal of Chemistry, 45, 16537–16542.

Article  CAS  Google Scholar 

Abraham, M. K., Anand, V., Madanan, A. S., Varghese, S., Shkhair, A. I., Indongo, G., Rajeevan, G., Sasidharanpillai, S. S., Muraleedharan, L. G., Subha, V. N., & George, S. (2023). Fluorescence “Turn-Off-On” detection of heparin and protamine based on bovine serum albumin-stabilized carbon dots (BSA-CDs). ChemNanoMat, 9, e202300115.

Article  CAS  Google Scholar 

Mei, J., Hong, Y., Lam, J. W. Y., Qin, A., Tang, Y., & Tang, B. Z. (2014). Aggregation-induced emission: The whole is more brilliant than the parts. Advanced Materials, 26, 5429–5479.

Article  CAS  PubMed  Google Scholar 

Ma, H., Yang, M., Zhang, C., Ma, Y., Qin, Y., Lei, Z., Chang, L., Lei, L., Wang, T., & Yang, Y. (2017). Aggregation-induced emission (AIE)-active fluorescent probes with multiple binding sites toward ATP sensing and live cell imaging. Journal of Materials Chemistry B, 5, 8525–8531.

Article  CAS  PubMed  Google Scholar 

Luo, J., Xie, Z., Lam, J. W. Y., Cheng, L., Chen, H., Qiu, C., Kwok, H.S., Zhan, X., Liu, Y., Zhu, D. & Tang, B. Z. (2001). Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole. Chemical Communications, 1740–1741.

Hong, Y., Lam, J. W. Y., & Tang, B. Z. (2011). Aggregation-induced emission. Chemical Society Reviews, 40, 5361–5388.

Article  CAS  PubMed  Google Scholar 

Zhao, N., Yang, Z., Lam, J. W. Y., Sung, H. H. Y., Xie, N., Chen, S., Su, H., Gao, M., Williams, I. D., Wong, K. S., & Tang, B. Z. (2012). Benzothiazolium-functionalized tetraphenylethene: An AIE luminogen with tunable solid-state emission. Chemical Communications, 48, 8637–8639.

Article  CAS  PubMed  Google Scholar 

Mal, D. K., Jonnalgadda, P. N., Chittela, R. K., & Chakraborty, G. (2023). Utilization of host assisted aggregation-induced emission of ANS dye for ATP sensing. Journal of Molecular Liquids, 376, 121402.

Article  Google Scholar 

Sarkar, S., Chakraborty, G., & Pal, H. (2024). Surfactant-based supramolecular dye assembly: A highly selective and economically viable platform for quantification of heparin antidote. Colloids and Surfaces, B, 237, 113839.

Article  CAS  Google Scholar

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