Mauvais-Jarvis F. Sex differences in energy metabolism: natural selection, mechanisms and consequences. Nat Rev Nephrol. 2024;20:56–69. https://doi.org/10.1038/s41581-023-00781-2.

Article  PubMed  Google Scholar 

Henderson VW, Brinton RD. Menopause and mitochondria: windows into estrogen effects on Alzheimer’s disease risk and therapy. Prog Brain Res. 2010;182:77–96. https://doi.org/10.1016/S0079-6123(10)82003-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanchez BN, Volek JS, Kraemer WJ, Saenz C, Maresh CM. Sex differences in energy metabolism: a female-oriented discussion. Sports Med. 2024;54:2033–57. https://doi.org/10.1007/s40279-024-02063-8.

Article  PubMed  Google Scholar 

Wang W, Yan Y, Guo Z, Hou H, Garcia M, Tan X, et al. All around suboptimal health – a joint position paper of the Suboptimal Health Study Consortium and European Association for Predictive, Preventive and Personalised Medicine. EPMA J. 2021;12:403–33. https://doi.org/10.1007/s13167-021-00253-2.

Article  PubMed  PubMed Central  Google Scholar 

Golubnitschaja O, Kapinova A, Sargheini N, Bojkova B, Kapalla M, Heinrich L, et al. Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation. EPMA J. 2024;15:163–205. https://doi.org/10.1007/s13167-024-00358-4.

Article  PubMed  PubMed Central  Google Scholar 

Shao Q, Ndzie Noah ML, Golubnitschaja O, Zhan X. Mitochondrial medicine: from bench to bedside 3PM-guided concept. EPMA J. 2025;16:239–64. https://doi.org/10.1007/s13167-025-00409-4.

Article  PubMed  PubMed Central  Google Scholar 

Golubnitschaja O, Polivka J, Potuznik P, Pesta M, Stetkarova I, Mazurakova A, et al. The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation. EPMA J. 2024;15:1–23. https://doi.org/10.1007/s13167-024-00356-6.

Article  PubMed  PubMed Central  Google Scholar 

Golubnitschaja O, Sargheini N, Bastert J. Mitochondria in cutaneous health, disease, ageing and rejuvenation—the 3PM-guided mitochondria-centric dermatology. EPMA J. 2025;16:1–15. https://doi.org/10.1007/s13167-025-00400-z.

Article  PubMed  PubMed Central  Google Scholar 

Koklesova L, Mazurakova A, Samec M, Kudela E, Biringer K, Kubatka P, et al. Mitochondrial health quality control: measurements and interpretation in the framework of predictive, preventive, and personalized medicine. EPMA J. 2022;13:177–93. https://doi.org/10.1007/s13167-022-00281-6.

Article  PubMed  PubMed Central  Google Scholar 

Pesta M, Mrazova B, Kapalla M, Kulda V, Gkika E, Golubnitschaja O. Mitochondria-based holistic 3PM approach as the game-changer for individualised rehabilitation-the proof-of-principle model by treated breast cancer survivors. EPMA J. 2024;15:559–71. https://doi.org/10.1007/s13167-024-00386-0.

Article  PubMed  PubMed Central  Google Scholar 

Lejri I, Grimm A, Eckert A. Mitochondria, estrogen and female brain aging. Front Aging Neurosci. 2018;10:124. https://doi.org/10.3389/fnagi.2018.00124.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Picard M, Wallace DC, Burelle Y. The rise of mitochondria in medicine. Mitochondrion. 2016;30:105–16. https://doi.org/10.1016/j.mito.2016.07.003.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang X, Gao Y, zhang S, Wang Y, Pei X, Chen Y, et al. Mitochondrial dysfunction in the regulation of aging and aging-related diseases. Cell Commun Signal. 2025;23:290. https://doi.org/10.1186/s12964-025-02308-7.

Article  PubMed  PubMed Central  Google Scholar 

Vryonidou A, Paschou SA, Muscogiuri G, Orio F, Goulis DG. Mechanisms in endocrinology: metabolic syndrome through the female life cycle. Eur J Endocrinol. 2015;173:R153–63. https://doi.org/10.1530/EJE-15-0275.

Article  CAS  PubMed  Google Scholar 

Boisseau N, Isacco L. Substrate metabolism during exercise: sexual dimorphism and women’s specificities. Eur J Sport Sci. 2022;22:672–83. https://doi.org/10.1080/17461391.2021.1943713.

Article  PubMed  Google Scholar 

LöFberg IE, Karppinen JE, Laatikainen-Raussi V, Lehti M, Hackney AC, Ihalainen JK, et al. Resting energy expenditure, metabolic and sex hormones in two phases of the menstrual and hormonal contraceptive cycles. Med Sci Sports Exerc. 2024;56:2285–95. https://doi.org/10.1249/MSS.0000000000003518.

Article  CAS  PubMed  Google Scholar 

Malo-Vintimilla L, Aguirre C, Vergara A, Fernández-Verdejo R, Galgani JE. Resting energy metabolism and sweet taste preference during the menstrual cycle in healthy women. Br J Nutr. 2024;131:384–90. https://doi.org/10.1017/S0007114523001927.

Article  CAS  PubMed  Google Scholar 

Hackney AC. Menstrual cycle hormonal changes and energy substrate metabolism in exercising women: a perspective. Int J Environ Res Public Health. 2021;18:10024. https://doi.org/10.3390/ijerph181910024.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ko S-H, Jung Y. Energy metabolism changes and dysregulated lipid metabolism in postmenopausal women. Nutrients. 2021;13:4556. https://doi.org/10.3390/nu13124556.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ko S-H, Kim H-S. Menopause-associated lipid metabolic disorders and foods beneficial for postmenopausal women. Nutrients. 2020;12:202. https://doi.org/10.3390/nu12010202.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goncharenko V, Bubnov R, Polivka J, Zubor P, Biringer K, Bielik T, et al. Vaginal dryness: individualised patient profiles, risks and mitigating measures. EPMA J. 2019;10:73–9. https://doi.org/10.1007/s13167-019-00164-3.

Article  PubMed  PubMed Central  Google Scholar 

Martuliak I, Golubnitschaja O, Chvala L, Kapalla M, Ferencik M, Bubeliny M, et al. Pain chronification risk assessment: advanced phenotyping and scoring for prediction and treatments tailored to individualized patient profile. EPMA J. 2024;15:739–50. https://doi.org/10.1007/s13167-024-00383-3.

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Diaz Brinton R. Estrogen regulation of mitochondrial respiration is cell type and ER subtype specific. Alzheimers Dement. 2017;13:P665-6. https://doi.org/10.1016/j.jalz.2017.06.801.

Article  Google Scholar 

Klinge CM. Estrogenic control of mitochondrial function. Redox Biol. 2020;31:101435. https://doi.org/10.1016/j.redox.2020.101435.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Irwin RW, Yao J, Hamilton RT, Cadenas E, Brinton RD, Nilsen J. Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. Endocrinology. 2008;149:3167–75. https://doi.org/10.1210/en.2007-1227.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beikoghli Kalkhoran S, Kararigas G. Oestrogenic regulation of mitochondrial dynamics. Int J Mol Sci. 2022;23:1118. https://doi.org/10.3390/ijms23031118.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Torrens-Mas M, Pons D-G, Sastre-Serra J, Oliver J, Roca P. Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications. Redox Biol. 2020;31:101505. https://doi.org/10.1016/j.redox.2020.101505.

Article  CAS  PubMed  PubMed Central