Volume 58, April 2026, 105395Author links open overlay panelAtılım Armağan Demirtaş a b, Başak Turun Bozkurt b, Berna Yüce a b, Tuncay Küsbeci a bShow moreHighlights•

This study evaluated the impact of MFCLs on OCT-derived structural parameters and image quality.

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MFCL wear is associated with reduced image quality in posterior segment OCT and lower measured RNFL thickness.

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Anterior segment image QI and GCIPL thickness measurements remain stable despite MFCL wear.

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Refractive status and MFCL spherical power modestly influence GCIPL thickness, while corneal curvature and addition power do not significantly affect OCT measurements.

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OCT imaging through MFCLs should be interpreted with caution, and baseline scans without lenses are preferable, especially for glaucoma screening.

AbstractPurpose

This study aimed to evaluate the influence of multifocal contact lenses (MFCLs) on structural optical coherence tomography (OCT) parameters, including central corneal thickness (CCT), ganglion cell–inner plexiform layer (GCIPL) thickness, and peripapillary retinal nerve fiber layer (RNFL) thickness. In addition, we assessed their effect on scan acquisition quality, as measured by the OCT quality index (QI).

Methods

A retrospective cross-sectional study was performed on 80 eyes of 40 female presbyopic participants (mean age 52.4 ± 6.1 years). All subjects were fitted with Acuvue Oasys Multifocal lenses (Johnson & Johnson Vision). OCT imaging was performed for the anterior segment, ganglion, and disc analyses both with and without MFCLs. Parameters assessed included CCT, average and minimum GCIPL thickness, average RNFL thickness, and scan QI. Only scans with QI ≥ 4 were included. Correlation analyses were performed between OCT parameters and clinical parameters (age, spherical equivalent, K1, K2, and corneal radius), and MFCL variables (spherical power and addition levels).

Results

Linear mixed model analysis revealed significant differences in several OCT parameters between lens-off and lens-on conditions. CCT slightly increased with MFCL wear (adjusted means of difference = +1.9 µm, p < 0.001), while anterior scan quality remained stable. In contrast, posterior segment scan quality decreased significantly in both ganglion (p = 0.003) and disc (p = 0.002) modules, accompanied by a reduction in average RNFL thickness (adjusted means of difference = –3.19 µm, p < 0.001). Correlation analyses showed that both spherical equivalent and MFCL spherical power were significantly associated with GCIPL thickness, suggesting a subtle optical influence of refractive status and lens power on retinal measurements. Addition levels showed no significant correlations with any OCT-derived parameters.

Conclusions

MFCL wear was associated with reduced OCT image quality in posterior segment imaging and with thinner RNFL measurements, while anterior segment quality and GCIPL parameters remained stable. Correlation analyses revealed that refractive status and lens spherical power subtly influenced GCIPL thickness. Therefore, OCT examinations in presbyopic patients should be interpreted with caution, and baseline scans without lens wear may be preferable, particularly in glaucoma screening.

Previous article in issueNext article in issueKeywords

Central corneal thickness

Ganglion cell-inner plexiform layer

Multifocal contact lenses

Optical coherence tomography

Retinal nerve fiber layer

Quality index

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© 2026 The Author(s). Published by Elsevier B.V.