Dissecting the aberrant vasculature of glioblastoma: mechanisms and therapeutic targets

Konig, S., et al. (2025). Mechanobiology of the blood-brain barrier during development, disease and ageing. Nature Communications, 16(1), 7233.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferreira, C., Sarmento, B., & Martins, C. (2025). In vitro models of the interplay between glioblastoma and blood-brain barrier for stratifying drug efficacy. Advanced Drug Delivery Reviews, 227, 115702.

Article  CAS  PubMed  Google Scholar 

Chen, X., et al. (2023). Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity. Neuron, 111(1), 30-48 e14.

Article  CAS  PubMed  Google Scholar 

Liang, H., et al. (2025). IL-1beta(+) tumor-associated macrophages accelerate glioblastoma progression by amplifying the PGE2-EP4 signaling. Journal of Neuroinflammation, 22(1), 233.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, J., et al. (2025). Immunopathology of glioblastoma. Annual Review of Pathology: Mechanisms of Disease, 21(1), 135-162. https://doi.org/10.1146/annurev-pathmechdis-042524-025950

Pinto-Fraga, J., et al. (2025). Protein kinase inhibitors as targeted therapy for glioblastoma: A meta-analysis of randomized controlled clinical trials. Pharmacological Research, 212, 107528.

Article  CAS  PubMed  Google Scholar 

Zhou, M. Y., et al. (2025). Stress-induced regional characteristics of the blood-brain barrier. Brain Research Bulletin. https://doi.org/10.1016/j.brainresbull.2025.111548

Article  PubMed  Google Scholar 

Bazzoni, G., & Dejana, E. (2004). Endothelial cell-to-cell junctions: Molecular organization and role in vascular homeostasis. Physiological Reviews, 84(3), 869–901.

Article  CAS  PubMed  Google Scholar 

Mittapalli, R. K., et al. (2010). Exploiting nutrient transporters at the blood-brain barrier to improve brain distribution of small molecules. Therapeutic Delivery, 1(6), 775–784.

Article  CAS  PubMed  Google Scholar 

Daneman, R., et al. (2010). Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature, 468(7323), 562–566.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wosik, K., et al. (2007). Angiotensin II controls occludin function and is required for blood brain barrier maintenance: Relevance to multiple sclerosis. Journal of Neuroscience, 27(34), 9032–9042.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abbott, N. J. (2002). Astrocyte-endothelial interactions and blood-brain barrier permeability. Journal of Anatomy, 200(6), 629–638.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mishra, A., et al. (2016). Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles. Nature Neuroscience, 19(12), 1619–1627.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Neuwelt, E. A. (2004). Mechanisms of disease: The blood-brain barrier. Neurosurgery, 54(1), 131–140. discussion 141–2.

Article  PubMed  Google Scholar 

Hirano, A., & Matsui, T. (1975). Vascular structures in brain tumors. Human Pathology, 6(5), 611–621.

Article  CAS  PubMed  Google Scholar 

Martin, J. D., Seano, G., & Jain, R. K. (2019). Normalizing function of tumor vessels: Progress, opportunities, and challenges. Annual Review of Physiology, 81, 505–534.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Plate, K. H., & Mennel, H. D. (1995). Vascular morphology and angiogenesis in glial tumors. Experimental and Toxicologic Pathology, 47(2–3), 89–94.

Article  CAS  PubMed  Google Scholar 

Dome, B., Timar, J., & Paku, S. (2003). A novel concept of glomeruloid body formation in experimental cerebral metastases. Journal of Neuropathology and Experimental Neurology, 62(6), 655–661.

Article  PubMed  Google Scholar 

Ribatti, D., & Pezzella, F. (2022). Vascular co-option and other alternative modalities of growth of tumor vasculature in glioblastoma. Frontiers in Oncology, 12, 874554.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wirsching, H. G., Roth, P., & Weller, M. (2021). A vasculature-centric approach to developing novel treatment options for glioblastoma. Expert Opinion on Therapeutic Targets, 25(2), 87–100.

Article  CAS  PubMed  Google Scholar 

Xie, Y., et al. (2024). Single-cell dissection of the human blood-brain barrier and glioma blood-tumor barrier. Neuron, 112(18), 3089-3105 e7.

Article  CAS  PubMed  Google Scholar 

Colorado, P. C., et al. (2000). Anti-angiogenic cues from vascular basement membrane collagen. Cancer Research, 60(9), 2520–2526.

CAS  PubMed  Google Scholar 

Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013). Development, maintenance and disruption of the blood-brain barrier. Nature Medicine, 19(12), 1584–1596.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nagashima, G., et al. (2002). Immunohistochemical analysis of reactive astrocytes around glioblastoma: An immunohistochemical study of postmortem glioblastoma cases. Clinical Neurology and Neurosurgery, 104(2), 125–131.

Article  PubMed  Google Scholar 

Du, Y., et al. (2025). Spatial-reprogramming derived GPNMB(+) macrophages interact with COL6A3(+) fibroblasts to enhance vascular fibrosis in glioblastoma. Genome Medicine, 17(1), 136.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bejarano, L., et al. (2025). Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors. Immunity, 58(4), 1015-1032 e6.

Article  CAS  PubMed  Google Scholar 

Xie, Y., et al. (2021). Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing. JCI Insight 6(15), e150861. https://doi.org/10.1172/jci.insight.150861

Tietz, S., & Engelhardt, B. (2015). Brain barriers: Crosstalk between complex tight junctions and adherens junctions. The Journal of Cell Biology, 209(4), 493–506.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lugassy, C., et al. (2002). Pericytic-like angiotropism of glioma and melanoma cells. American Journal of Dermatopathology, 24(6), 473–478.

Article  PubMed  Google Scholar 

Hashizume, H., et al. (2000). Openings between defective endothelial cells explain tumor vessel leakiness. American Journal of Pathology, 156(4), 1363–1380.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jhaveri, N., Chen, T. C., & Hofman, F. M. (2016). Tumor vasculature and glioma stem cells: Contributions to glioma progression. Cancer Letters, 380(2), 545–551.

Article  CAS  PubMed  Google Scholar 

Giannotta, M., Trani, M., & Dejana, E. (2013). VE-cadherin and endothelial adherens junctions: Active guardians of vascular integrity. Developmental Cell, 26(5), 441–454.

Article  CAS  PubMed 

Comments (0)

No login
gif