The impact of genomic ancestry on tumor genomics in head and neck squamous cell carcinoma

Johnson, D. E., Burtness, B., Leemans, C. R., Lui, V. W. Y., Bauman, J. E., & Grandis, J. R. (2020). Head and neck squamous cell carcinoma. Nature Reviews Disease Primers, 6(1), 1–22.

Article  Google Scholar 

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249.

PubMed  Google Scholar 

Siegel, R. L., Kratzer, T. B., Giaquinto, A. N., Sung, H., & Jemal, A. (2025). Cancer statistics, 2025. Ca, 75(1), 10.

PubMed  PubMed Central  Google Scholar 

Farah, C. S. (2021). Molecular landscape of head and neck cancer and implications for therapy. Annals of Translational Medicine, 9(10), Article 915.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee, K. K., Rishishwar, L., Ban, D., Nagar, S. D., Mariño-Ramírez, L., McDonald, J. F., et al. (2022). Association of genetic ancestry and molecular signatures with cancer survival disparities: A pan-cancer analysis. Cancer Research, 82(7), 1222–1233.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zandberg, D. P., Liu, S., Goloubeva, O., Ord, R., Strome, S. E., Suntharalingam, M., et al. (2016). Oropharyngeal cancer as a driver of racial outcome disparities in squamous cell carcinoma of the head and neck: 10-year experience at the University of Maryland Greenebaum Cancer Center. Head & Neck, 38(4), 564–572.

Article  Google Scholar 

Liu, J. C., Egleston, B. L., Blackman, E., & Ragin, C. (2023). Racial survival disparities in head and neck cancer clinical trials. Journal of the National Cancer Institute, 115(3), 288–294.

Article  PubMed  Google Scholar 

Ragin, C. C., Langevin, S. M., Marzouk, M., Grandis, J., & Taioli, E. (2011). Determinants of head and neck cancer survival by race. Head & neck, 33(8), 1092–1098.

Article  Google Scholar 

Zhang, W., Edwards, A., Flemington, E. K., & Zhang, K. (2017). Racial disparities in patient survival and tumor mutation burden, and the association between tumor mutation burden and cancer incidence rate. Scientific Reports, 7(1), Article 13639.

Article  PubMed  PubMed Central  Google Scholar 

Vyfhuis, M. A. L., Suzuki, I., Bentzen, S. M., Cullen, K. J., & Goloubeva, O. G. (2021). Adherence to guideline-concordant care and its effect on survival in Black patients with head and neck cancers: A SEER-Medicare analysis. The Oncologist, 26(7), 579–587.

Article  PubMed  PubMed Central  Google Scholar 

Wu, E. S., Park, J. Y., Zeitouni, J. A., Gomez, C. R., Reis, I. M., Zhao, W., et al. (2016). Effect of actionable somatic mutations on racial/ethnic disparities in head and neck cancer prognosis. Head & Neck, 38(8), 1234–1241.

Article  Google Scholar 

Rylands, J., Lowe, D., & Rogers, S. N. (2016). Outcomes by area of residence deprivation in a cohort of oral cancer patients: Survival, health-related quality of life, and place of death. Oral Oncology, 52, 30–36.

Article  PubMed  Google Scholar 

Auluck, A., Walker, B. B., Hislop, G., Lear, S. A., Schuurman, N., Rosin, M., et al. (2016). Socio-economic deprivation: A significant determinant affecting stage of oral cancer diagnosis and survival. BMC Cancer, 16(1), 569.

Article  PubMed  PubMed Central  Google Scholar 

Ravaghi, V., Durkan, C., Jones, K., Girdler, R., Mair-Jenkins, J., Davies, G., et al. (2020). Area-level deprivation and oral cancer in England 2012-2016. Cancer Epidemiology, 69, 101840. https://doi.org/10.1016/j.canep.2020.101840

Reitzel, L. R., Nguyen, N., Zafereo, M. E., Li, G., Wei, Q., & Sturgis, E. M. (2012). Neighborhood deprivation and clinical outcomes among head and neck cancer patients. Health & Place, 18(4), 861–868. https://doi.org/10.1016/j.healthplace.2012.03.005

Garcia, L., Follis, S., Thomson, C. A., Breathett, K., Cené, C. W., Jimenez, M., et al. (2022). Taking action to advance the study of race and ethnicity: The Women’s Health Initiative (WHI). Women’s Midlife Health, 8(1), Article 1.

Article  PubMed  PubMed Central  Google Scholar 

Gopalan, S., Smith, S. P., Korunes, K., Hamid, I., Ramachandran, S., & Goldberg, A. (2022). Human genetic admixture through the lens of population genomics. Philosophical Transactions of the Royal Society B, Biological Sciences. https://doi.org/10.1098/rstb.2020.0410

Article  PubMed  PubMed Central  Google Scholar 

Borrell, L. N., Elhawary, J. R., Fuentes-Afflick, E., Witonsky, J., Bhakta, N., Wu, A. H. B., et al. (2021). Race and genetic ancestry in medicine — A time for reckoning with racism. New England Journal of Medicine, 384(5), 474–480.

Article  PubMed  Google Scholar 

Royal, C. D., Novembre, J., Fullerton, S. M., Goldstein, D. B., Long, J. C., Bamshad, M. J., et al. (2010). Inferring genetic ancestry: Opportunities, challenges, and implications. The American Journal of Human Genetics, 86(5), 661–673.

Article  CAS  PubMed  Google Scholar 

Guo, J., Liu, X., Zeng, Y., Liang, T., Tang, K., & Zheng, W. (2021). Comprehensive analysis of the effects of genetic ancestry and genetic characteristics on the clinical evolution of oral squamous cell carcinoma. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2021.678464

Article  PubMed  PubMed Central  Google Scholar 

Lawrence, M. S., Sougnez, C., Lichtenstein, L., Cibulskis, K., Lander, E., Gabriel, S. B., et al. (2015). Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature, 517(7536), 576–582.

Article  CAS  Google Scholar 

Morris, L. G. T., Kaufman, A. M., Gong, Y., Ramaswami, D., Walsh, L. A., Turcan, Ş, et al. (2013). Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nature Genetics, 45(3), 253–261.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang, F., Chen, F., Shay, C., Chen, G. Z., Saba, N. F., & Teng, Y. (2024). Exploring the impact of GSTM1 as a novel molecular determinant of survival in head and neck cancer patients of African descent. Journal of Experimental & Clinical Cancer Research, 43(1), Article 203.

Article  CAS  Google Scholar 

Lan, T., Ge, Q., Zheng, K., Huang, L., Yan, Y., Zheng, L., et al. (2022). FAT1 Upregulates in Oral Squamous Cell Carcinoma and Promotes Cell Proliferation via Cell Cycle and DNA Repair. Frontiers in Oncology, 12, 870055. https://doi.org/10.3389/fonc.2022.870055

Chen, Z. G., Saba, N. F., & Teng, Y. (2022). The diverse functions of FAT1 in cancer progression: Good, bad, or ugly? Journal of Experimental & Clinical Cancer Research, 41(1), 248.

Article  CAS  Google Scholar 

Ramakodi, M. P., Devarajan, K., Blackman, E., Gibbs, D., Luce, D., Deloumeaux, J., et al. (2017). Integrative genomics analysis identifies ancestral-related eQTLs on POLB, and supports the association of genetic ancestry with survival disparity in HNSCC. Cancer, 123(5), 849–860.

Article  CAS  PubMed  Google Scholar 

Gohil, D., Sarker, A. H., & Roy, R. (2023). Base excision repair: Mechanisms and impact in biology, disease, and medicine. International Journal of Molecular Sciences, 24(18), Article 14186.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shpilman, Z., & Kidane, D. (2024). Dysregulation of base excision repair factors associated with low tumor immunogenicity in head and neck cancer: Implication for immunotherapy. Therapeutic Advances in Medical Oncology, 16, Article 17588359241248330.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mezghani, N., Yao, A., Vasilyeva, D., Kaplan, N., Shackelford, A., Yoon, A., et al. (2023). Molecular subtypes of head and neck cancer in patients of african ancestry. Clinical Cancer Research, 29(5), 910–920.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan, J., Hu, Z., Mahal, B. A., Zhao, S. D., Kensler, K. H., Pi, J., et al. (2018). Integrated analysis of genetic ancestry and genomic alterations across cancers. Cancer Cell, 34(4), 549–60.e9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carrot-Zhang, J., Chambwe, N., Damrauer, J. S., Knijnenburg, T. A., Robertson, A. G., Yau, C., et al. (2020). Comprehensive analysis of genetic ancestry and its molecular correlates in cancer. Cancer Cell, 37(5), 639–54.e6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Canning, M., Guo, G., Yu, M., Myint, C., Groves, M. W., Byrd, J. K., et al. (2019). Heterogeneity of the head and neck squamous cell carcinoma immune landscape and its impact on immunotherapy. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2019.00052

Article  PubMed  PubMed Central  Google Scholar 

Krieger, T., Pearson, I., Bell, J., Doherty, J., & Robbins, P. (2020). Targeted literature review on use of tumor mutational burden status and programmed cell death ligand 1 expression to predict outcomes of checkpoint inhibitor treatment. Diagnostic Pathology, 15(1), Article 6.

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