Johnson, D. E., Burtness, B., Leemans, C. R., Lui, V. W. Y., Bauman, J. E., & Grandis, J. R. (2020). Head and neck squamous cell carcinoma. Nature Reviews Disease Primers, 6(1), 1–22.
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249.
Siegel, R. L., Kratzer, T. B., Giaquinto, A. N., Sung, H., & Jemal, A. (2025). Cancer statistics, 2025. Ca, 75(1), 10.
PubMed PubMed Central Google Scholar
Farah, C. S. (2021). Molecular landscape of head and neck cancer and implications for therapy. Annals of Translational Medicine, 9(10), Article 915.
Article CAS PubMed PubMed Central Google Scholar
Lee, K. K., Rishishwar, L., Ban, D., Nagar, S. D., Mariño-Ramírez, L., McDonald, J. F., et al. (2022). Association of genetic ancestry and molecular signatures with cancer survival disparities: A pan-cancer analysis. Cancer Research, 82(7), 1222–1233.
Article CAS PubMed PubMed Central Google Scholar
Zandberg, D. P., Liu, S., Goloubeva, O., Ord, R., Strome, S. E., Suntharalingam, M., et al. (2016). Oropharyngeal cancer as a driver of racial outcome disparities in squamous cell carcinoma of the head and neck: 10-year experience at the University of Maryland Greenebaum Cancer Center. Head & Neck, 38(4), 564–572.
Liu, J. C., Egleston, B. L., Blackman, E., & Ragin, C. (2023). Racial survival disparities in head and neck cancer clinical trials. Journal of the National Cancer Institute, 115(3), 288–294.
Ragin, C. C., Langevin, S. M., Marzouk, M., Grandis, J., & Taioli, E. (2011). Determinants of head and neck cancer survival by race. Head & neck, 33(8), 1092–1098.
Zhang, W., Edwards, A., Flemington, E. K., & Zhang, K. (2017). Racial disparities in patient survival and tumor mutation burden, and the association between tumor mutation burden and cancer incidence rate. Scientific Reports, 7(1), Article 13639.
Article PubMed PubMed Central Google Scholar
Vyfhuis, M. A. L., Suzuki, I., Bentzen, S. M., Cullen, K. J., & Goloubeva, O. G. (2021). Adherence to guideline-concordant care and its effect on survival in Black patients with head and neck cancers: A SEER-Medicare analysis. The Oncologist, 26(7), 579–587.
Article PubMed PubMed Central Google Scholar
Wu, E. S., Park, J. Y., Zeitouni, J. A., Gomez, C. R., Reis, I. M., Zhao, W., et al. (2016). Effect of actionable somatic mutations on racial/ethnic disparities in head and neck cancer prognosis. Head & Neck, 38(8), 1234–1241.
Rylands, J., Lowe, D., & Rogers, S. N. (2016). Outcomes by area of residence deprivation in a cohort of oral cancer patients: Survival, health-related quality of life, and place of death. Oral Oncology, 52, 30–36.
Auluck, A., Walker, B. B., Hislop, G., Lear, S. A., Schuurman, N., Rosin, M., et al. (2016). Socio-economic deprivation: A significant determinant affecting stage of oral cancer diagnosis and survival. BMC Cancer, 16(1), 569.
Article PubMed PubMed Central Google Scholar
Ravaghi, V., Durkan, C., Jones, K., Girdler, R., Mair-Jenkins, J., Davies, G., et al. (2020). Area-level deprivation and oral cancer in England 2012-2016. Cancer Epidemiology, 69, 101840. https://doi.org/10.1016/j.canep.2020.101840
Reitzel, L. R., Nguyen, N., Zafereo, M. E., Li, G., Wei, Q., & Sturgis, E. M. (2012). Neighborhood deprivation and clinical outcomes among head and neck cancer patients. Health & Place, 18(4), 861–868. https://doi.org/10.1016/j.healthplace.2012.03.005
Garcia, L., Follis, S., Thomson, C. A., Breathett, K., Cené, C. W., Jimenez, M., et al. (2022). Taking action to advance the study of race and ethnicity: The Women’s Health Initiative (WHI). Women’s Midlife Health, 8(1), Article 1.
Article PubMed PubMed Central Google Scholar
Gopalan, S., Smith, S. P., Korunes, K., Hamid, I., Ramachandran, S., & Goldberg, A. (2022). Human genetic admixture through the lens of population genomics. Philosophical Transactions of the Royal Society B, Biological Sciences. https://doi.org/10.1098/rstb.2020.0410
Article PubMed PubMed Central Google Scholar
Borrell, L. N., Elhawary, J. R., Fuentes-Afflick, E., Witonsky, J., Bhakta, N., Wu, A. H. B., et al. (2021). Race and genetic ancestry in medicine — A time for reckoning with racism. New England Journal of Medicine, 384(5), 474–480.
Royal, C. D., Novembre, J., Fullerton, S. M., Goldstein, D. B., Long, J. C., Bamshad, M. J., et al. (2010). Inferring genetic ancestry: Opportunities, challenges, and implications. The American Journal of Human Genetics, 86(5), 661–673.
Article CAS PubMed Google Scholar
Guo, J., Liu, X., Zeng, Y., Liang, T., Tang, K., & Zheng, W. (2021). Comprehensive analysis of the effects of genetic ancestry and genetic characteristics on the clinical evolution of oral squamous cell carcinoma. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2021.678464
Article PubMed PubMed Central Google Scholar
Lawrence, M. S., Sougnez, C., Lichtenstein, L., Cibulskis, K., Lander, E., Gabriel, S. B., et al. (2015). Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature, 517(7536), 576–582.
Morris, L. G. T., Kaufman, A. M., Gong, Y., Ramaswami, D., Walsh, L. A., Turcan, Ş, et al. (2013). Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nature Genetics, 45(3), 253–261.
Article CAS PubMed PubMed Central Google Scholar
Yang, F., Chen, F., Shay, C., Chen, G. Z., Saba, N. F., & Teng, Y. (2024). Exploring the impact of GSTM1 as a novel molecular determinant of survival in head and neck cancer patients of African descent. Journal of Experimental & Clinical Cancer Research, 43(1), Article 203.
Lan, T., Ge, Q., Zheng, K., Huang, L., Yan, Y., Zheng, L., et al. (2022). FAT1 Upregulates in Oral Squamous Cell Carcinoma and Promotes Cell Proliferation via Cell Cycle and DNA Repair. Frontiers in Oncology, 12, 870055. https://doi.org/10.3389/fonc.2022.870055
Chen, Z. G., Saba, N. F., & Teng, Y. (2022). The diverse functions of FAT1 in cancer progression: Good, bad, or ugly? Journal of Experimental & Clinical Cancer Research, 41(1), 248.
Ramakodi, M. P., Devarajan, K., Blackman, E., Gibbs, D., Luce, D., Deloumeaux, J., et al. (2017). Integrative genomics analysis identifies ancestral-related eQTLs on POLB, and supports the association of genetic ancestry with survival disparity in HNSCC. Cancer, 123(5), 849–860.
Article CAS PubMed Google Scholar
Gohil, D., Sarker, A. H., & Roy, R. (2023). Base excision repair: Mechanisms and impact in biology, disease, and medicine. International Journal of Molecular Sciences, 24(18), Article 14186.
Article CAS PubMed PubMed Central Google Scholar
Shpilman, Z., & Kidane, D. (2024). Dysregulation of base excision repair factors associated with low tumor immunogenicity in head and neck cancer: Implication for immunotherapy. Therapeutic Advances in Medical Oncology, 16, Article 17588359241248330.
Article CAS PubMed PubMed Central Google Scholar
Mezghani, N., Yao, A., Vasilyeva, D., Kaplan, N., Shackelford, A., Yoon, A., et al. (2023). Molecular subtypes of head and neck cancer in patients of african ancestry. Clinical Cancer Research, 29(5), 910–920.
Article CAS PubMed PubMed Central Google Scholar
Yuan, J., Hu, Z., Mahal, B. A., Zhao, S. D., Kensler, K. H., Pi, J., et al. (2018). Integrated analysis of genetic ancestry and genomic alterations across cancers. Cancer Cell, 34(4), 549–60.e9.
Article CAS PubMed PubMed Central Google Scholar
Carrot-Zhang, J., Chambwe, N., Damrauer, J. S., Knijnenburg, T. A., Robertson, A. G., Yau, C., et al. (2020). Comprehensive analysis of genetic ancestry and its molecular correlates in cancer. Cancer Cell, 37(5), 639–54.e6.
Article CAS PubMed PubMed Central Google Scholar
Canning, M., Guo, G., Yu, M., Myint, C., Groves, M. W., Byrd, J. K., et al. (2019). Heterogeneity of the head and neck squamous cell carcinoma immune landscape and its impact on immunotherapy. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2019.00052
Article PubMed PubMed Central Google Scholar
Krieger, T., Pearson, I., Bell, J., Doherty, J., & Robbins, P. (2020). Targeted literature review on use of tumor mutational burden status and programmed cell death ligand 1 expression to predict outcomes of checkpoint inhibitor treatment. Diagnostic Pathology, 15(1), Article 6.
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