Volume 43, March 2026, 101421Author links open overlay panelElizabeth Jansen van Rensburg 1, Louisa B. Seopela, Leon C. SnymanShow moreHighlights•

We address methodological concerns raised by Waseem et al.

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We clarify choice of study design.

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We comment on study strengths.

Abstract

We have submitted a response to the letter to the editor by Waseem et al. wherein we address the concerns raised regarding methodological validity.

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Access through your organizationSection snippetsSingle centre versus multicentre design

While we acknowledge that multicentre studies offer advantages in terms of generalisability, our single-centre prospective design provides important strengths. The PETRA study referenced by the authors was conducted over a two-year period across multiple sites. This study, conducted at Kalafong Provincial Tertiary Hospital over 12 months, enrolled 248 patients from a well-defined catchment area serving the western region of Tshwane. This single-centre approach ensured standardised management

Conclusion

This study makes a valuable contribution to the preeclampsia literature by demonstrating that proteinuria severity, measured by the practical and accessible UPCR, correlates with earlier delivery and development of severe features, particularly HELLP syndrome. These findings have immediate clinical utility for risk stratification and patient counseling in settings like ours.

We agree with the authors that preeclampsia warrants continued research attention. Our work provides specific, actionable

Declaration of competing interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References (7)

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1

Present address: Mediclinic Kloof Private Hospital, 511 Jochemus St, Erasmuskloof, 0048.

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© 2026 Published by Elsevier B.V. on behalf of International Society for the Study of Hypertension in Pregnancy.