Fehr JS, Bloemberg GV, Ritter C, Hombach M, Luscher TF, Weber R, Keller PM (2010) Septicemia caused by tick-borne bacterial pathogen Candidatus Neoehrlichia mikurensis. Emerg Infect Dis 16:1127–1129. https://doi.org/10.3201/eid1607.091907
Article PubMed PubMed Central Google Scholar
Welinder-Olsson C, Kjellin E, Vaht K, Jacobsson S, WenneråS C (2010) First case of human “Candidatus Neoehrlichia mikurensis” infection in a febrile patient with chronic lymphocytic leukemia. J Clin Microbiol 48:1956–1959. https://doi.org/10.1128/jcm.02423-09
Article PubMed PubMed Central Google Scholar
Von Loewenich FD, GeißdöRfer W, Disqué C, Matten J, Schett G, Sakka SG, Bogdan C (2010) Detection of “Candidatus Neoehrlichia mikurensis” in two patients with severe febrile illnesses: evidence for a European sequence variant. J Clin Microbiol 48:2630–2635. https://doi.org/10.1128/jcm.00588-10
Grankvist A, Andersson PO, Mattsson M, Sender M, Vaht K, Hoper L, Sakiniene E, Trysberg E, Stenson M, Fehr J, Pekova S, Bogdan C, Bloemberg G, Wenneras C (2014) Infections with the tick-borne bacterium “Candidatus Neoehrlichia mikurensis” mimic noninfectious conditions in patients with B cell malignancies or autoimmune diseases. Clin Infect Dis 58:1716–1722. https://doi.org/10.1093/cid/ciu189
Article CAS PubMed Google Scholar
Höper L, Skoog E, Stenson M, Grankvist A, Wass L, Olsen B, Nilsson K, Mårtensson A, Söderlind J, Sakinis A, Wennerås C (2021) Vasculitis due to Candidatus Neoehrlichia mikurensis: a cohort study of 40 Swedish patients. Clin Infect Dis 73:e2372–e2378. https://doi.org/10.1093/cid/ciaa1217
Wass L, Grankvist A, Bell-Sakyi L, Bergström M, Ulfhammer E, Lingblom C, Wennerås C (2019) Cultivation of the causative agent of human neoehrlichiosis from clinical isolates identifies vascular endothelium as a target of infection. Emerg Microbes Infect 8:413–425. https://doi.org/10.1080/22221751.2019.1584017
Article CAS PubMed PubMed Central Google Scholar
Wennerås C, Wass L, Bergström B, Grankvist A, Lingblom C (2024) Ten years of detecting Neoehrlichia mikurensis infections in Sweden: demographic, clinical and inflammatory parameters. Eur J Clin Microbiol Infect Dis 43:2083–2092. https://doi.org/10.1007/s10096-024-04909-5
Article PubMed PubMed Central Google Scholar
Boyer PH, Baldinger L, Degeilh B, Wirth X, Kamdem CM, Hansmann Y, Zilliox L, Boulanger N, Jaulhac B (2021) The emerging tick-borne pathogen Neoehrlichia mikurensis: first French case series and vector epidemiology. Emerg Microbes Infect 10:1731–1738. https://doi.org/10.1080/22221751.2021.1973347
Article CAS PubMed PubMed Central Google Scholar
Grankvist A, Sandelin LL, Andersson J, Fryland L, Wilhelmsson P, Lindgren P-E, Forsberg P, Wennerås C (2015) Infections with Candidatus Neoehrlichia mikurensis and cytokine responses in 2 persons bitten by ticks, Sweden. Emerg Infect Dis 21:1462–1465. https://doi.org/10.3201/eid2108.150060
Article CAS PubMed PubMed Central Google Scholar
Labbé Sandelin L, Olofsson J, Tolf C, Rohlén L, Brudin L, Tjernberg I, Lindgren P-E, Olsen B, Waldenström J (2022) Detection of Neoehrlichia mikurensis DNA in blood donors in southeastern Sweden. Infect Dis Lond. https://doi.org/10.1080/23744235.2022.2087732
Markowicz M, Schötta A-M, Höss D, Kundi M, Schray C, Stockinger H, Stanek G (2021) Infections with tickborne pathogens after tick bite, Austria, 2015–2018. Emerg Infect Dis. https://doi.org/10.3201/eid2704.203366
Article PubMed PubMed Central Google Scholar
Welc-Falęciak R, Siński E, Kowalec M, Zajkowska J, Pancewicz SA (2014) Asymptomatic “Candidatus Neoehrlichia mikurensis” infections in immunocompetent humans. J Clin Microbiol 52:3072–3074. https://doi.org/10.1128/jcm.00741-14
Article PubMed PubMed Central Google Scholar
Dahlberg AO, Aase A, Reiso H, Midgard R, Quarsten H (2025) Detection of Neoehrlichia mikurensis in 11 persons who attribute their persistent health complaints to a tick-borne disease. Ticks Tick-borne Dis 16:102391. https://doi.org/10.1016/j.ttbdis.2024.102391
Goren A, Mysterud A, Jore S, Viljugrein H, Bakka H, Vindenes Y (2023) Demographic patterns in Lyme borreliosis seasonality over 25 years. Zoonoses Public Health 70:647–655. https://doi.org/10.1111/zph.13073
Wennerås C (2015) Infections with the tick-borne bacterium Candidatus Neoehrlichia mikurensis. Clin Microbiol Infect 21:621–630. https://doi.org/10.1016/j.cmi.2015.02.030
Grankvist A, Jaén-Luchoro D, Wass L, Sikora P, Wennerås C (2021) Comparative genomics of clinical isolates of the emerging tick-borne pathogen Neoehrlichia mikurensis. Microorganisms 9:1488. https://doi.org/10.3390/microorganisms9071488
Article CAS PubMed PubMed Central Google Scholar
Zhi N, Rikihisa Y, Kim HY, Wormser GP, Horowitz HW (1997) Comparison of major antigenic proteins of six strains of the human granulocytic ehrlichiosis agent by Western immunoblot analysis. J Clin Microbiol 35:2606–2611. https://doi.org/10.1128/jcm.35.10.2606-2611.1997
Article CAS PubMed PubMed Central Google Scholar
Grankvist A, Moore ER, Svensson Stadler L, Pekova S, Bogdan C, Geissdorfer W, Grip-Linden J, Brandstrom K, Marsal J, Andreasson K, Lewerin C, Welinder-Olsson C, Wenneras C (2015) Multilocus sequence analysis of clinical “Candidatus Neoehrlichia mikurensis” strains from Europe. J Clin Microbiol 53:3126–3132. https://doi.org/10.1128/JCM.00880-15
Article CAS PubMed PubMed Central Google Scholar
Wass L, Grankvist A, Mattsson M, Gustafsson H, Krogfelt K, Olsen B, Nilsson K, Martensson A, Quarsten H, Henningsson AJ, Wenneras C (2018) Serological reactivity to Anaplasma phagocytophilum in neoehrlichiosis patients. Eur J Clin Microbiol Infect Dis 37:1673–1678. https://doi.org/10.1007/s10096-018-3298-3
Article CAS PubMed PubMed Central Google Scholar
Wenneras C, Aranburu A, Wass L, Grankvist A, Staffas A, Soboli A, Martensson IL, Fogelstrand L, Lewerin C (2023) Infection with Neoehrlichia mikurensis promotes the development of malignant B-cell lymphomas. Br J Haematol 201:480–488. https://doi.org/10.1111/bjh.18652
Article CAS PubMed Google Scholar
Sivalingam GN, Shepherd AJ (2012) An analysis of B-cell epitope discontinuity. Mol Immunol 51:304–309. https://doi.org/10.1016/j.molimm.2012.03.030
Article CAS PubMed PubMed Central Google Scholar
Quarsten H, Grankvist A, Høyvoll L, Myre IB, Skarpaas T, Kjelland V, Wenneras C, Noraas S (2017) CandidatusNeoehrlichia mikurensis and Borrelia burgdorferi sensu lato detected in the blood of Norwegian patients with erythema migrans. Ticks Tick-borne Dis 8:715–720. https://doi.org/10.1016/j.ttbdis.2017.05.004
Article CAS PubMed Google Scholar
Quarsten H, Salte T, Lorentzen ÅR, Hansen IJW, Hamre R, Forselv KJN, Øines Ø, Wennerås C, Noraas S (2021) Tick-borne pathogens detected in the blood of immunosuppressed Norwegian patients living in a tick-endemic area. Clin Infect Dis 73:e2364–e2371. https://doi.org/10.1093/cid/ciaa971
Article CAS PubMed Google Scholar
Kridin K, Ahmed AR (2020) Post-rituximab immunoglobulin M (IgM) hypogammaglobulinemia. Autoimmun Rev 19:102466. https://doi.org/10.1016/j.autrev.2020.102466
Article CAS PubMed Google Scholar
Grönwall C, Vas J, Silverman GJ (2012) Protective roles of natural IgM antibodies. Front Immunol. https://doi.org/10.3389/fimmu.2012.00066
Article PubMed PubMed Central Google Scholar
Wennerås C, Goldblatt D, Zancolli M, Mattsson M, Wass L, Hörkkö S, Rosén A (2017) Natural IgM antibodies in the immune defence against neoehrlichiosis. Infect Dis 49:809–816. https://doi.org/10.1080/23744235.2017.1347815
Jones DD, DeIulio GA, Winslow GM (2012) Antigen-driven induction of polyreactive IgM during intracellular bacterial infection. J Immunol 189:1440–1447.
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