Al Shweiki, M. R., Oeckl, P., Steinacker, P., Barschke, P., Dorner-Ciossek, C., Hengerer, B., et al. (2020). Proteomic analysis reveals a biosignature of decreased synaptic protein in cerebrospinal fluid of major depressive disorder. Translational Psychiatry, 10, Article 144. https://doi.org/10.1038/s41398-020-0825-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ananbeh, H., Vodicka, P., & Kupcova Skalnikova, H. (2021). Emerging roles of exosomes in Huntington’s disease. International Journal of Molecular Sciences, 22(8), Article 4085. https://doi.org/10.3390/ijms22084085

Article  CAS  PubMed  PubMed Central  Google Scholar 

Antoniou, A., Auderset, L., Kaurani, L., Sebastian, E., Zeng, Y., Allahham, M., et al. (2023). Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF. Cell Reports, 42(2), Article 112063. https://doi.org/10.1016/j.celrep.2023.112063

Article  CAS  PubMed  Google Scholar 

Arnold, F. J., Nguyen, A. D., Bedlack, R. S., Bennett, C. L., & La Spada, A. R. (2023). Intercellular transmission of pathogenic proteins in ALS: Exploring the pathogenic wave. Neurobiology of Disease, 184, Article 106218. https://doi.org/10.1016/j.nbd.2023.106218

Article  CAS  PubMed  Google Scholar 

Athauda, D., Gulyani, S., Karnati, H. kumar, Li, Y., Tweedie, D., Mustapic, M., et al. (2019). Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease. JAMA Neurology, 76(4), 420–429. https://doi.org/10.1001/jamaneurol.2018.4304

Badhwar, A., Hirschberg, Y., Valle‐Tamayo, N., Iulita, M. F., Udeh‐Momoh, C. T., Matton, A., et al. (2024). Assessment of brain‐derived extracellular vesicle enrichment for blood biomarker analysis in age‐related neurodegenerative diseases: An international overview. Alzheimer’s & Dementia, 20(7), 4411–4422. https://doi.org/10.1002/alz.13823

Article  CAS  Google Scholar 

Banigan, M. G., Kao, P. F., Kozubek, J. A., Winslow, A. R., Medina, J., Costa, J., et al. (2013). Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patients. PLoS ONE, 8(1), Article e48814. https://doi.org/10.1371/journal.pone.0048814

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berumen Sánchez, G., Bunn, K. E., Pua, H. H., & Rafat, M. (2021). Extracellular vesicles: Mediators of intercellular communication in tissue injury and disease. Cell Communication and Signaling, 19(1), Article 104. https://doi.org/10.1186/s12964-021-00787-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cariaga-Martinez, A., Saiz-Ruiz, J., & Alelú-Paz, R. (2016). From linkage studies to epigenetics: What we know and what we need to know in the neurobiology of schizophrenia. Frontiers in Neuroscience, 10, Article 202. https://doi.org/10.3389/fnins.2016.00202

Article  PubMed  PubMed Central  Google Scholar 

Cha, D. J., Mengel, D., Mustapic, M., Liu, W., Selkoe, D. J., Kapogiannis, D., et al. (2019). miR-212 and miR-132 are downregulated in neurally derived plasma exosomes of Alzheimer’s patients. Frontiers in Neuroscience, 13, Article 1208. https://doi.org/10.3389/fnins.2019.01208

Article  PubMed  PubMed Central  Google Scholar 

Chen, S., Bao, Q., Xu, W., & Zhai, X. (2025). Extracellular particles: Emerging insights into central nervous system diseases. Journal of Nanobiotechnology, 23, Article 263. https://doi.org/10.1186/s12951-025-03354-6

Article  PubMed  PubMed Central  Google Scholar 

Chiaradia, E., Tancini, B., Emiliani, C., Delo, F., Pellegrino, R. M., Tognoloni, A., et al. (2021). Extracellular Vesicles under Oxidative Stress Conditions: Biological Properties and Physiological Roles. Cells, 10(7), 1763. https://doi.org/10.3390/cells10071763

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chinnathambi, S., Kumarappan, M., Malik, S., Velmurugan, G., & Chandrashekar, M. (2025). Neuron-derived extracellular vesicle-based diagnostics for Tau and Alzheimer’s disease. Brain Network Disorders. https://doi.org/10.1016/j.bnd.2024.12.006

Article  Google Scholar 

Cohn, W., Melnik, M., Huang, C., Teter, B., Chandra, S., Zhu, C., et al. (2021). Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer’s Disease Brain Tissue Reveals Disease-Associated Signatures. Frontiers in Pharmacology, 12, Article 766082. https://doi.org/10.3389/fphar.2021.766082

Article  CAS  PubMed  PubMed Central  Google Scholar 

Correia, A. S., Cardoso, A., & Vale, N. (2023). BDNF Unveiled: Exploring Its Role in Major Depression Disorder Serotonergic Imbalance and Associated Stress Conditions. Pharmaceutics, 15(8), 2081. https://doi.org/10.3390/pharmaceutics15082081

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Ceglia, R., Ledonne, A., Litvin, D. G., Lind, B. L., Carriero, G., Latagliata, E. C., et al. (2023). Specialized astrocytes mediate glutamatergic gliotransmission in the CNS. Nature, 622(7981), 120–129. https://doi.org/10.1038/s41586-023-06502-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Debnath, M., Venkatasubramanian, G., & Berk, M. (2015). Fetal programming of schizophrenia: Select mechanisms. Neuroscience & Biobehavioral Reviews, 49, 90–104. https://doi.org/10.1016/j.neubiorev.2014.12.003

Article  Google Scholar 

Dehghani, S., Ocakcı, O., Hatipoglu, P. T., Özalp, V. C., & Tevlek, A. (2025). Exosomes as Biomarkers and Therapeutic Agents in Neurodegenerative Diseases: Current Insights and Future Directions. Molecular Neurobiology, 62(7), 9190–9215. https://doi.org/10.1007/s12035-025-04825-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong, X., Dong, J., & Zhang, J. (2023). Roles and therapeutic potential of different extracellular vesicle subtypes on traumatic brain injury. Cell Communication and Signaling, 21(1), 211. https://doi.org/10.1186/s12964-023-01165-6

Article  PubMed  PubMed Central  Google Scholar 

Du, Y., Chen, L., Li, X.-S., Li, X.-L., Xu, X.-D., Tai, S.-B., et al. (2020). Metabolomic Identification of Exosome-Derived Biomarkers for Schizophrenia: A Large Multicenter Study. Schizophrenia Bulletin, 47(3), 615–623. https://doi.org/10.1093/schbul/sbaa166

Article  Google Scholar 

Dutta, S., Hornung, S., Taha, H. B., & Bitan, G. (2023). Biomarkers for parkinsonian disorders in CNS-originating EVs: Promise and challenges. Acta Neuropathologica, 145(5), 515–540. https://doi.org/10.1007/s00401-023-02557-1

Article  PubMed  PubMed Central  Google Scholar 

Edwards, K. A., Leete, J. J., Smith, E. G., Quick, A., Modica, C. M., Wassermann, E. M., et al. (2022). Elevations in tumor necrosis factor alpha and interleukin 6 from neuronal-derived extracellular vesicles in repeated low-level blast exposed personnel. Frontiers in Neurology, 13, Article 723923. https://doi.org/10.3389/fneur.2022.723923

Article  PubMed  PubMed Central  Google Scholar 

Fries, G. R., Saldana, V. A., Finnstein, J., & Rein, T. (2023). Molecular pathways of major depressive disorder converge on the synapse. Molecular Psychiatry, 28(1), 284–297. https://doi.org/10.1038/s41380-022-01806-1

Article  CAS  PubMed  Google Scholar 

Gabrielli, M., Prada, I., Joshi, P., Falcicchia, C., D’Arrigo, G., Rutigliano, G., et al. (2022). Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer’s disease. Brain, 145(8), 2849–2868. https://doi.org/10.1093/brain/awac083

Article  PubMed  PubMed Central  Google Scholar 

Gagliardi, D., Bresolin, N., Comi, G. P., & Corti, S. (2020). Extracellular vesicles and amyotrophic lateral sclerosis: From misfolded protein vehicles to promising clinical biomarkers. Cellular and Molecular Life Sciences : CMLS, 78(2), 561–572. https://doi.org/10.1007/s00018-020-03619-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goetzl, E. J., Kapogiannis, D., Schwartz, J. B., Lobach, I. V., Goetzl, L., Abner, E. L., et al. (2016a). Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer’s disease. FASEB Journal, 30(12), 4141–4148. https://doi.org/10.1096/fj.201600816R

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goetzl, E. J., Mustapic, M., Kapogiannis, D., Eitan, E., Lobach, I. V., Goetzl, L., et al. (2016b). Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease. FASEB Journal, 30(11), 3853–3859. https://doi.org/10.1096/fj.201600756R

Article  CAS  PubMed  PubMed Central