Chen N, Luan Y (2025) Specific expression and common potential therapeutic drugs in different brain regions of major depressive disorder patients: bioinformatics analysis. J Affect Disord 382:478–487

Article  CAS  PubMed  Google Scholar 

Cui L, Li S, Wang S, Wu X, Liu Y, Yu W, Wang Y, Tang Y, Xia M, Li B (2024) Major depressive disorder: hypothesis, mechanism, prevention and treatment. Signal Transduct Target therapy 9:30

Article  CAS  Google Scholar 

De Melo GO, Muzitano MF, Legora-Machado A, Almeida TA, De Oliveira DB, Kaiser CR, Koatz VLG, Costa SS (2005) C-glycosylflavones from the aerial parts of Eleusine indica inhibit LPS-induced mouse lung inflammation. Planta Med 71:362–363

Article  PubMed  Google Scholar 

Dong X, Bai Y, Liao Z, Gritsch D, Liu X, Wang T, Borges-Monroy R, Ehrlich A, Serrano GE, Feany MB (2023) Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease. Nat Commun 14:5327

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fava GA, Guidi J (2023) Clinical characterization of demoralization. Psychother Psychosom 92:139–147

Article  PubMed  Google Scholar 

Frid LM, Kessler U, Ousdal OT, Hammar Å, Haavik J, Riemer F, Hirnstein M, Ersland L, Erchinger VJ, Ronold EH (2023) Neurobiological mechanisms of ECT and TMS treatment in depression: study protocol of a multimodal magnetic resonance investigation. BMC Psychiatry 23:791

Article  PubMed  PubMed Central  Google Scholar 

Ge Y, Chen R, Ling T, Liu B, Huang J, Cheng Y, Lin Y, Chen H, Xie X, Xia G (2024) Elevated WTAP promotes hyperinflammation by increasing m 6 A modification in inflammatory disease models. J Clin Investig 134:20

Article  Google Scholar 

Gibbons A, Sundram S, Dean B (2020) Changes in non-coding RNA in depression and bipolar disorder: can they be used as diagnostic or theranostic biomarkers? Non-coding RNA 6:33

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greer TL (2021) Circular RNAs as putative biomarkers for depression diagnosis and treatment. EBioMedicine 68:103362

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hatzimanolis O, Sykes AM, Cristino AS (2025) Circular RNAs in neurological conditions – computational identification, functional validation, and potential clinical applications. Mol Psychiatry 30:1652–1675

Article  PubMed  PubMed Central  Google Scholar 

He M-C, Feng R, Wang J, Xia S-H, Wang Y-J, Zhang Y (2022a) Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action. Front Aging Neurosci 14:950143

Article  CAS  PubMed  PubMed Central  Google Scholar 

He Y, Han Y, Liao X, Zou M, Wang Y (2022b) Biology of cyclooxygenase-2: An application in depression therapeutics. Front Psychiatry 13:1037588

Article  PubMed  PubMed Central  Google Scholar 

Hu Y, Gan Y, Lei J, Cai J, Zhou Y, Chen H, Zhang Q, Shi Y (2025) Schaftoside Reduces Depression-and Anxiogenic-like Behaviors in Mice Depression Models. Brain Sci 15:238

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang R, Zhang Y, Bai Y, Han B, Ju M, Chen B, Yang L, Wang Y, Zhang H, Zhang H (2020) N6-methyladenosine modification of fatty acid amide hydrolase messenger RNA in circular RNA STAG1–regulated astrocyte dysfunction and depressive-like behaviors. Biol Psychiatry 88:392–404

Article  CAS  PubMed  Google Scholar 

Jazvinšćak Jembrek M, Oršolić N, Karlović D, Peitl V (2023) Flavonols in action: Targeting oxidative stress and neuroinflammation in major depressive disorder. Int J Mol Sci 24:6888

Article  PubMed  PubMed Central  Google Scholar 

Jia Y, Yuan X, Feng L, Xu Q, Fang X, Xiao D, Li Q, Wang Y, Ye L, Wang P (2024) m6A-modified circCacna1c regulates necroptosis and ischemic myocardial injury by inhibiting Hnrnpf entry into the nucleus. Cell Mol Biology Lett 29:140

Article  CAS  Google Scholar 

Li Q, Wen S, Ye W, Zhao S, Liu X (2021) The potential roles of m6A modification in regulating the inflammatory response in microglia. J Neuroinflamm 18:149

Article  CAS  Google Scholar 

Li P, Huang W, Chen Y, Aslam MS, Cheng W, Huang Y, Chen W, Huang Y, Wu X, Yan Y (2023a) Acupuncture alleviates CUMS-induced depression‐like behaviors by restoring prefrontal cortex neuroplasticity. Neural plasticity 2023:1474841

Li Y, Li J, Yu Q, Ji L, Peng B (2023b) METTL14 regulates microglia/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis. Neurobiol Dis 185:106253

Article  CAS  PubMed  Google Scholar 

Liang ZY, Zhang JY, Huang YC, Zhou CJ, Wang YW, Zhou CH, Xing SP, Shun QS, Xu YX, Wei G (2019) Identification of flavonoids in Dendrobium huoshanense and comparison with those in allied species of Dendrobium by TLC, HPLC and HPLC coupled with electrospray ionization multi-stage tandem MS analyses. J Sep Sci 42:1088–1104

CAS  PubMed  Google Scholar 

Liu Y, Chen Z, Lin W, Zhou Y, Liu Z, Zhao R, Chen Y, Wu B, Chen A, Lin C (2022) Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome. Front Cell Neurosci 16:1010107

Article  CAS  PubMed  PubMed Central  Google Scholar 

Livneh I, Moshitch-Moshkovitz S, Amariglio N, Rechavi G, Dominissini D (2020) The m6A epitranscriptome: transcriptome plasticity in brain development and function. Nat Rev Neurosci 21:36–51

Article  CAS  PubMed  Google Scholar 

Marx W, Penninx BW, Solmi M, Furukawa TA, Firth J, Carvalho AF, Berk M (2023) Major depressive disorder. Nat Reviews Disease Primers 9:44

Article  PubMed  Google Scholar 

Meng M, Zhong ZY, Song L, Zhang ZH, Yin XF, Xie XQ, Tian L, Wei W, Yang Y, Deng YF, Peng HY, Deng Y (2024) mTOR signaling promotes rapid m6A mRNA methylation to regulate NK-cell activation and effector functions. Cancer Immunol Res 12(8):1039–1057

Article  CAS  PubMed  Google Scholar 

Ngo AL, Nguyen L, Gharavi Alkhansari N, Zhang H (2025) m6A RNA Methylation in Psychiatric Disorders: An Emerging Epitranscriptomic Axis. Epigenomes 9:36

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nowakowska K, Walkiewicz G, Stec-Martyna E, Kulczycka-Wojdala D, Frankowska E, Miler P, Pawlak A, Woźniak K, Krejca M, Wilczyński M (2025) Circulating Brain-Related miRNAs as Predictors of Postoperative Delirium in Cardiac Surgery Patients. Int J Mol Sci 26:9062

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sălcudean A, Bodo C-R, Popovici R-A, Cozma M-M, Păcurar M, Crăciun R-E, Crisan A-I, Enatescu V-R, Marinescu I, Cimpian D-M (2025) Neuroinflammation—A Crucial Factor in the Pathophysiology of Depression—A. Compr Rev Biomolecules 15:502

Article  Google Scholar 

Simon GE, Moise N, Mohr DC (2024) Management of depression in adults: a review. JAMA 332:141–152

Article  CAS  PubMed  Google Scholar 

Siwek M, Woroń J, Wrzosek A, Gupało J, Chrobak AA (2023) Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs. Front Pharmacol 14:1271776

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan L, Zhao W, Wang H, Huang X, Li R, Yin L, Liu X, Wang J, Wu N, Wang H (2025) Dysfunctional circular RNA network in major depressive disorder: dissecting the cell identity and potential clinical applications. Mol Psychiatry 31:498–513

Article  PubMed  Google Scholar 

Troubat R, Barone P, Leman S, Desmidt T, Cressant A, Atanasova B, Brizard B, El Hage W, Surget A, Belzung C (2021) Neuroinflammation and depression: A review. Eur J Neurosci 53:151–171

Article  CAS  PubMed  Google Scholar 

Wang P, Ma H, Zhang Y, Zeng R, Yu J, Liu R, Jin X, Zhao Y (2020) Plasma exosome-derived microRNAs as novel biomarkers of traumatic brain injury in rats. Int J Med Sci 17:437