Benedetto L, Rivas M, Pereira M, Ferreira A, Torterolo P (2017) A descriptive analysis of sleep and wakefulness states during maternal behaviors in postpartum rats. Arch Ital Biol 155:99–109
Benedetto L, Pena F, Rivas M, Ferreira A, Torterolo P (2023) The integration of the maternal care with sleep during the postpartum period. Sleep Med Clin 18:499–509
Brisbare-Roch C, Dingemanse J, Koberstein R, Hoever P, Aissaoui H, Flores S, Mueller C, Nayler O, van Gerven J, de Haas SL (2007) Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat Med 13:150–155
Article PubMed CAS Google Scholar
Carrera-Canas C, Garzon M, de Andres I (2019) The transition between slow-wave sleep and REM sleep constitutes an independent sleep stage organized by cholinergic mechanisms in the rostrodorsal pontine tegmentum. Front Neurosci 13:748
Article PubMed PubMed Central Google Scholar
Carrera-Cañas C, Rivas M, Callejo M, De Andrés I, Torterolo P, Garzón M (2024) Acute effects of suvorexant on the proportions and architecture of the sleep-wake cycle stages in wild-type rats: induction of narcoleptic traits. Sleep Medicine 115: S204
Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437–451
Article PubMed CAS Google Scholar
Cox CD, Breslin MJ, Whitman DB, Schreier JD, McGaughey GB, Bogusky MJ, Roecker AJ, Mercer SP, Bednar RA, Lemaire W, Bruno JG, Reiss DR, Harrell CM, Murphy KL, Garson SL, Doran SM, Prueksaritanont T, Anderson WB, Tang C, Roller S, Cabalu TD, Cui D, Hartman GD, Young SD, Koblan KS, Winrow CJ, Renger JJ, Coleman PJ (2010) Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H–1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia. J Med Chem 53:5320–5332
Article PubMed CAS Google Scholar
D’Anna KL, Gammie SC (2006) Hypocretin-1 dose-dependently modulates maternal behaviour in mice. J Neuroendocrinol 18:553–566
Article PubMed PubMed Central Google Scholar
Deferm N, Dinh J, Pansari A, Jamei M, Abduljalil K (2025) Postpartum changes in maternal physiology and milk composition: a comprehensive database for developing lactation physiologically-based pharmacokinetic models. Front Pharmacol 16:1517069
Article PubMed PubMed Central CAS Google Scholar
Diniz GB, Candido PL, Klein MO, Alvisi RD, Presse F, Nahon JL, Felicio LF, Bittencourt JC (2018) The weaning period promotes alterations in the orexin neuronal population of rats in a suckling-dependent manner. Brain Struct Funct 223:3739–3755
Article PubMed CAS Google Scholar
Donlin M, Cavanaugh BL, Spagnuolo OS, Yan L, Lonstein JS (2014) Effects of sex and reproductive experience on the number of orexin A-immunoreactive cells in the prairie vole brain. Peptides 57:122–128
Article PubMed CAS Google Scholar
Espana RA, Berridge CW, Gammie SC (2004) Diurnal levels of Fos immunoreactivity are elevated within hypocretin neurons in lactating mice. Peptides 25:1927–1934
Article PubMed CAS Google Scholar
Gamble MC, Katsuki F, McCoy JG, Strecker RE, McKenna JT (2021) The dual orexin receptor antagonist DORA-22 improves mild stress-induced sleep disruption during the natural sleep phase of nocturnal rats. Neuroscience 463:30–44
Article PubMed CAS Google Scholar
Gotter AL, Garson SL, Stevens J, Munden RL, Fox SV, Tannenbaum PL, Yao L, Kuduk SD, McDonald T, Uslaner JM, Tye SJ, Coleman PJ, Winrow CJ, Renger JJ (2014) Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators. BMC Neurosci 15:109
Article PubMed PubMed Central Google Scholar
Han AH, Burroughs CR, Falgoust EP, Hasoon J, Hunt G, Kakazu J, Lee T, Kaye AM, Kaye AD, Ganti L (2022) Suvorexant, a novel dual orexin receptor antagonist, for the management of insomnia. Health Psychol Res 10:67898
Herring WJ, Connor KM, Ivgy-May N, Snyder E, Liu K, Snavely DB, Krystal AD, Walsh JK, Benca RM, Rosenberg R, Sangal RB, Budd K, Hutzelmann J, Leibensperger H, Froman S, Lines C, Roth T, Michelson D (2016) Suvorexant in patients with insomnia: results from two 3-month randomized controlled clinical trials. Biol Psychiatry 79:136–148
Article PubMed CAS Google Scholar
Ito H, Fukatsu N, Rahaman SM, Mukai Y, Izawa S, Ono D, Kilduff TS, Yamanaka A (2023) Deficiency of orexin signaling during sleep is involved in abnormal REM sleep architecture in narcolepsy. Proc Natl Acad Sci U S A 120:e2301951120
Article PubMed PubMed Central CAS Google Scholar
Kallo I, Omrani A, Meye FJ, de Jong H, Liposits Z, Adan RAH (2022) Characterization of orexin input to dopamine neurons of the ventral tegmental area projecting to the medial prefrontal cortex and shell of nucleus accumbens. Brain Struct Funct 227:1083–1098
Article PubMed PubMed Central CAS Google Scholar
Kaufmann P, Muehlan C, Anliker-Ort M, Sabattini G, Siebers N, Dingemanse J (2024) Transfer of the dual orexin receptor antagonist Daridorexant into breast milk of healthy lactating women. J Clin Pharmacol 64:1278–1287
Article PubMed CAS Google Scholar
Khazaie H, Sadeghi M, Khazaie S, Hirshkowitz M, Sharafkhaneh A (2022) Dual orexin receptor antagonists for treatment of insomnia: a systematic review and meta-analysis on randomized, double-blind, placebo-controlled trials of suvorexant and lemborexant. Front Psychiatry 13:1070522
Article PubMed PubMed Central Google Scholar
de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS 2nd, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 95:322–327
Li SB, de Lecea L (2020) The hypocretin (orexin) system: from a neural circuitry perspective. Neuropharmacology 167:107993
Article PubMed CAS Google Scholar
Lincoln DW, Hill A, Wakerley JB (1973) The milk-ejection reflex of the rat: an intermittent function not abolished by surgical levels of anaesthesia. J Endocrinol 57:459–476
Article PubMed CAS Google Scholar
Matheson I, Sande HA, Gaillot J (1990) The excretion of zopiclone into breast milk. Br J Clin Pharmacol 30:267–271
Article PubMed PubMed Central CAS Google Scholar
Molik E, Zieba DA, Misztal T, Romanowicz K, Wszola M, Wierzchos E, Nowakowski M (2008) The role of orexin A in the control of prolactin and growth hormone secretions in sheep–in vitro study. J Physiol Pharmacol 59(Suppl 9):91–100
Monti JM, Torterolo P, Pandi-Perumal SR (2016) The effects of benzodiazepine and nonbenzodiazepine agents, ramelteon, low-dose doxepin, suvorexant, and selective serotonin 5-HT2A receptor antagonists andmInverse agonists on sleep and wakefulness. Clin Med Insights Ther 8:29–36
Nishihara K, Horiuchi S (1998) Changes in sleep patterns of young women from late pregnancy to postpartum: relationships to their infants’ movements. Percept Mot Skills 87:1043–1056
Article PubMed CAS Google Scholar
Nishino S, Sakurai T (2005) The orexin/hypocretin system: physiology and pathophysiology. Springer Science & Business Media
Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E (2000) Hypocretin (orexin) deficiency in human narcolepsy. Lancet 355:39–40
Article PubMed CAS Google Scholar
Norman JL, Anderson SL (2016) Novel class of medications, orexin receptor antagonists, in the treatment of insomnia - critical appraisal of suvorexant. Nat Sci Sleep 8:239–247
Article PubMed PubMed Central Google Scholar
Numan M (1974) Medial preoptic area and maternal behavior in the female rat. J Comp Physiol Psychol 87:746–759
Article PubMed CAS Google Scholar
Palagini L, Bramante A, Baglioni C, Tang N, Grassi L, Altena E, Johann AF, Geoffroy PA, Biggio G, Mencacci C, Sharma V, Riemann D (2022) Insomnia evaluation and treatment during peripartum: a joint position paper from the European Insomnia Network task force “Sleep and Women,” the Italian Marce Society and international experts task force for perinatal mental health. Arch Womens Ment Health 25:561–575
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