Correction: Spatial transcriptomic profiling identifies lacrimal-gland-epithelial cell-driven mechanisms underlying autoimmunity in Sjögren’s disease

There was a mistake in Figure 3, panel A as published. Group labels included above the two heat maps “TSP-1-/-” and “WT” were inadvertently switched. The status indicated by the group of first 9 orange columns was labeled as “TSP-1-/-” and the group of following 14 pink columns was labeled as “WT”. The corrected Figure 3, panel A appears below.

Panel A shows two heatmaps comparing gene expression of Na/K+ and mitochondrial ATPases, ion channels, and solute transporters between TSP-1 deficient and wild-type mouse samples. Panel B presents immunofluorescence images of duct epithelium stained for ENaC in wild-type and TSP-1 deficient tissues, with nuclei counterstained in blue and the duct outlined in white. Panel C contains a dot plot showing mitochondrial electron transport related pathway enrichment, with dot size and color representing gene ratio and adjusted p-value, respectively. Panel D is a violin plot comparing Camk2n1 expression between TSP-1 knockout and wild-type, indicating higher levels in wild-type samples.

Ion transport and calcium signaling are altered in TSP-1-deficient duct epithelial cells. (A) Heatmaps illustrating the expression patterns of ATPasesand ion channels (left) and ion and solute transport related genes (right) in duct epithelial cells. In the heatmap on the left side black boxes includeNa + /K +and Ca + ATPases (top) and Cl-, Na+ and K+ ion channels (bottom) and mitochondrial ATPases outside boxes. (B) Representativeimmunofluorescence images of ENaC (epithelial sodium channel) (red) and nuclei (blue) in duct epithelium. White outlines highlight ductalstructures. (C) Pathways enriched in significantly downregulated DEGs. (D) Violin plot comparing Camk2n1 expression in duct epithelial cells (*q-value <0.05).

The original version of this article has been updated.

Keywords

acinar epithelial cells, antigen presenting cells, autoimmunity, duct epithelial cells, lacrimal gland, Sjögren’s disease, spatial transcriptomics

Citation

Gupta S, Ploumakis A, Kalavros N and Masli S (2026) Correction: Spatial transcriptomic profiling identifies lacrimal-gland-epithelial cell-driven mechanisms underlying autoimmunity in Sjögren’s disease. Front. Immunol. 17:1832246. doi: 10.3389/fimmu.2026.1832246

Received

17 March 2026

Accepted

25 March 2026

Published

06 April 2026

Volume

17 - 2026

Edited and reviewed by

Li Zhou, Henry Ford Health System, United States

Updates

Copyright

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Sharmila Masli,

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