Non-Titanised Compared to Titanised Polypropylene Meshes Induce a Pro-Inflammatory and Anti-Angiogenic Response in Fibroblast Co-Cultures

Collins, S., & Lewicky-Gaupp, C. (2022). Pelvic organ prolapse. Gastroenterology Clinics of North America, 51(1), 177–193.

Article  PubMed  Google Scholar 

Wu, J. M., Vaughan, C. P., Goode, P. S., Redden, D. T., Burgio, K. L., Richter, H. E., & Markland, A. D. (2014). Prevalence and trends of symptomatic pelvic floor disorders in U.S. women. Obstetrics and Gynecology, 123(1), 141–148.

Article  PubMed Central  PubMed  Google Scholar 

Ramalingam, K., & Monga, A. (2015). Obesity and pelvic floor dysfunction. Best Practice and Research. Clinical Obstetrics and Gynaecology, 29(4), 541–547.

Article  PubMed  Google Scholar 

de Sam Lazaro, S., Nardos, R., & Caughey, A. B. (2016). Obesity and pelvic floor dysfunction: Battling the bulge. Obstetrical & Gynecological Survey, 71(2), 114–125.

Article  Google Scholar 

Lince, S. L., van Kempen, L. C., Vierhout, M. E., & Kluivers, K. B. (2012). A systematic review of clinical studies on hereditary factors in pelvic organ prolapse. International Urogynecology Journal, 23(10), 1327–1336.

Article  PubMed Central  PubMed  Google Scholar 

Tinelli, A., Malvasi, A., Rahimi, S., Negro, R., Vergara, D., Martignago, R., Pellegrino, M., & Cavallotti, C. (2010). Age-related pelvic floor modifications and prolapse risk factors in postmenopausal women. Menopause, 17(1), 204–212.

Article  PubMed  Google Scholar 

Jackson, S. R., Avery, N. C., Tarlton, J. F., Eckford, S. D., Abrams, P., & Bailey, A. J. (1996). Changes in metabolism of collagen in genitourinary prolapse. Lancet, 347(9016), 1658–1661.

Article  CAS  PubMed  Google Scholar 

Patel, D. A., Xu, X., Thomason, A. D., Ransom, S. B., Ivy, J. S., & DeLancey, J. O. (2006). Childbirth and pelvic floor dysfunction: An epidemiologic approach to the assessment of prevention opportunities at delivery. American Journal of Obstetrics and Gynecology, 195(1), 23–28.

Article  PubMed Central  PubMed  Google Scholar 

Weintraub, A. Y., Glinter, H., & Marcus-Braun, N. (2020). Narrative review of the epidemiology, diagnosis and pathophysiology of pelvic organ prolapse. International braz j urol : official journal of the Brazilian Society of Urology, 46(1), 5–14.

Article  PubMed Central  PubMed  Google Scholar 

Bø, K. (2012). Pelvic floor muscle training in treatment of female stress urinary incontinence, pelvic organ prolapse and sexual dysfunction. World Journal of Urology, 30(4), 437–443.

Article  PubMed  Google Scholar 

Griebling, T. L. (2016). Vaginal pessaries for treatment of pelvic organ prolapse in elderly women. Current Opinion in Urology, 26(2), 201–206.

Article  PubMed  Google Scholar 

Hagen, S., Glazener, C., McClurg, D., Macarthur, C., Elders, A., Herbison, P., Wilson, D., Toozs-Hobson, P., Hemming, C., Hay-Smith, J., Collins, M., Dickson, S., & Logan, J. (2017). Pelvic floor muscle training for secondary prevention of pelvic organ prolapse (PREVPROL): A multicentre randomised controlled trial. Lancet, 389(10067), 393–402.

Article  PubMed  Google Scholar 

Hagen, S., & Stark, D. (2011). Conservative prevention and management of pelvic organ prolapse in women. Cochrane Database of Systematic Reviews, 2011(12), CD003882.

Article  PubMed Central  PubMed  Google Scholar 

Wiegersma, M., Panman, C. M. C. R., Hesselink, L. C., Malmberg, A. G. A., Berger, M. Y., Kollen, B. J., & Dekker, J. H. (2019). Predictors of success for pelvic floor muscle training in pelvic organ prolapse. Physical Therapy, 99(1), 109–117.

Article  PubMed  Google Scholar 

Viereck, V., Bader, W., Lobodasch, K., Pauli, F., Bentler, R., & Kolbl, H. (2016). Guideline-based strategies in the surgical treatment of female urinary incontinence: The new gold standard is almost the same as the old one. Geburtshilfe Und Frauenheilkunde, 76(8), 865–868.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Murphy, A. M., Clark, C. B., Denisenko, A. A., D’Amico, M. J., & Vasavada, S. P. (2021). Surgical management of vaginal prolapse: current surgical concepts. The Canadian journal of urology, 28(S2), 22–26.

PubMed  Google Scholar 

Protsepko, O., Voisard, P., Kuhn, C., Maccagno, A., Dannecker, C., Jeschke, U., Pauli, F., & Garrido, F. (2023). Induction of a different immune response in non-titanized compared to titanized polypropylene meshes. Acta biomaterialia, 169, 363–371.

Article  PubMed  Google Scholar 

Xiao, Y., Zuo, X., Li, H., Zhao, Y., & Wang, X. (2023). Impact of titanium-coated polypropylene mesh on functional outcome and quality of life after inguinal hernia repair. Heliyon, 9(7), e17691.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Köckerling, F., & Schug-Pass, C. (2014). What do we know about titanized polypropylene meshes? An evidence-based review of the literature. Hernia, 18(4), 445–457.

Article  PubMed  Google Scholar 

Campagna, G., Pedone Anchora, L., Panico, G., Caramazza, D., Arcieri, M., Cervigni, M., Scambia, G., & Ercoli, A. (2020). Titanized polypropylene mesh in laparoscopic sacral colpopexy. International Urogynecology Journal, 31(4), 763–768.

Article  PubMed  Google Scholar 

Cadenbach-Blome, T., Grebe, M., Mengel, M., Pauli, F., Greser, A., & Funfgeld, C. (2019). Significant improvement in quality of life, positive effect on sexuality, lasting reconstructive result and low rate of complications following cystocele correction using a lightweight, large-pore, titanised polypropylene mesh: Final results of a national, multicentre observational study. Geburtshilfe Und Frauenheilkunde, 79(9), 959–968.

Article  PubMed Central  PubMed  Google Scholar 

Guo, T., Hu, X., Du, Z., Wang, X., Lang, J., Liu, J., Xu, H., & Sun, Z. (2024). Modification of transvaginal polypropylene mesh with co-axis electrospun nanofibrous membrane to alleviate complications following surgical implantation. Journal of Nanobiotechnology, 22(1), 598.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Ai, F. F., Mao, M., Zhang, Y., Kang, J., & Zhu, L. (2020). Experimental study of a new original mesh developed for pelvic floor reconstructive surgery. International Urogynecology Journal, 31(1), 79–89.

Article  PubMed  Google Scholar 

Lu, C., Zhou, J., Kong, Q., Wang, L., Ni, W., & Xiao, Z. (2025). New rat model mimicking sacrocolpopexy for POP treatment and biomaterials testing via unilateral presacral suspension. International Urogynecology Journal, 36(2), 421–429.

Article  PubMed Central  PubMed  Google Scholar 

Kim, Y. H., Panda, A. K., & Shevach, E. M. (2025). Treg control of CD80/CD86 expression mediates immune system homeostasis. European Journal of Immunology, 55(5), e202551771.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Wang, Q., Schmoeckel, E., Kost, B. P., Kuhn, C., Vattai, A., Vilsmaier, T., Mahner, S., Mayr, D., Jeschke, U., & Heidegger, H. H. (2019). Higher CCL22+ cell infiltration is associated with poor prognosis in cervical cancer patients. Cancers, 11(12), 2004.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Mannewitz, M., Kolben, T., Perleberg, C., Meister, S., Hahn, L., Mitter, S., Schmoeckel, E., Mahner, S., Corradini, S., Trillsch, F., Kessler, M., Jeschke, U., & Beyer, S. (2024). CCL22 as an independent prognostic factor in endometrial cancer patients. Translational Oncology, 50, 102116.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Boutilier, A. J., & Elsawa, S. F. (2021). Macrophage polarization states in the tumor microenvironment. International Journal of Molecular Sciences, 22(13), 6995.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Wang, L. X., Zhang, S. X., Wu, H. J., Rong, X. L., & Guo, J. (2019). M2b macrophage polarization and its roles in diseases. Journal of Leukocyte Biology, 106(2), 345–358.

Article  CAS  PubMed  Google Scholar 

Toyokawa, H., Nakao, A., Bailey, R. J., Nalesnik, M. A., Kaizu, T., Lemoine, J. L., Ikeda, A., Tomiyama, K., Papworth, G. D., Huang, L., Demetris, A. J., Starzl, T. E., & Murase, N. (2008). Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation. Liver Transplantation, 14(3), 346–357.

Article  PubMed Central  PubMed  Google Scholar 

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