Pereda-Miranda R, Rosas-Ramírez D, Castañeda-Gómez J (2010) Resin glycosides from morning glory family. In: Kinghorn AD, Falk H, Kobayashi J (eds) Progress in the chemistry of organic natural products, vol 92. Springer, New York, pp 77–153

Google Scholar 

Ono M (2017) Resin glycosides from convolvulaceae plants. J Nat Med 71:591–604

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lee SR, Chung KH, Kim HS (1969) Sugar constituents of Jalapin from sweet potato tubers. J Korean Chem Soc 13(1):96–101

CAS  Google Scholar 

Useful plants of the world (1989) In: Hotta M, Ogata K, Nitta A, Hoshikawa K, Yanagi M, Yamazaki K (eds) Heibonsha Ltd., Tokyo, Japan, p. 196 (In Japanese plant dictionary)

Ono M, Ichihara Y, Saito N, Yamada M, Yuuki K, Nawata M, Tsutsumi S, Yasuda S, Tsuchihashi R, Okawa M, Kinjo J, Nohara T (2020) Identification and characterization of organic and glycosidic acids in crude resin glycoside fraction from Calystegia hederacea. J Nat Med 74:200–211

Article  PubMed  Google Scholar 

Ono M, Yuhara N, Shimohara T, Matsubara S, Yasuda S, Tsuchihashi R, Okawa M, Kinjo J, Zhou JR, Yoshimitsu H, Nohara T (2021) Calyhedins I–VI: resin glycosides from the rhizomes of Calystegia hederacea. Phytochemistry 190:112888

Article  PubMed  CAS  Google Scholar 

Ono M, Shimohara T, Yuhara N, Matsubara S, Yasuda S, Tsuchihashi R, Okawa M, Kinjo J, Yoshimitsu H, Nohara T (2023) Four new resin glycosides, Calyhedins VII–X, from the rhizomes of Calystegia Hederacea. Nat Prod Res 37:1328–1337

Article  PubMed  CAS  Google Scholar 

Ono M, Yamano Y, Shimohara T, Yuhara N, Misuda N, Nishikawa H, Yasuda S, Miyashita H, Yoshimitsu H, Tsuchihashi R, Okawa M, Kinjo J (2023) Five new resin glycosides, calyhedins XI-XV, from Calystegia hederacea. J Nat Med 77:774–791

Article  PubMed  CAS  Google Scholar 

Ono M, Arakawa R, Nishikawa H, Misuda N, Yasuda S, Yoshimitsu H, Tsuchihashi R, Okawa M, Kinjo J (2024) Isolation and structural characterization of eight new resin glycosides, calyhedins XVI–XXIII, from the rhizomes of Calystegia hederacea. Carbohydr Res 535:108993. https://doi.org/10.1016/j.carres.2023.108993

Article  PubMed  CAS  Google Scholar 

Ono M, Matsuoka Y, Arakawa R, Shimadzu H, Nagasawa T, Nishikawa H, Yasuda S, Miyashita H, Yokomizo K, Yoshimitsu H, Tsuchihashi R, Okawa M, Kinjo J (2025) Eight new resin glycosides, Calyhedins XXIV–XXXI, from the rhizomes of Calystegia Hederacea. J Nat Med 79:845–862. https://doi.org/10.1007/s11418-025-01919-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ono M, Taketomi S, Nishikawa H, Yasuda S, Tsuchihashi R, Okawa M, Kinjo J, Miyashita H, Yoshimitsu H, Nohara T (2024) Two new resin glycosides, muricatins XII and XIII, from the seeds of Ipomoea muricata. Nat Prod Res 38:423–432

Article  PubMed  CAS  Google Scholar 

Moreno-Velasco A, Fragoso-Serrano M, Flores-Tafoya PJ, Carrillo-Rojas S, Bautista E, Leitão SG, Castañeda-Gómez JF, Pereda-Miranda R (2024) Inhibition of multidrug-resistant MCF-7 breast cancer cells with combinations of clinical drugs and resin glycosides from Operculina hamiltonii. Phytochemistry 217:113922. https://doi.org/10.1016/j.phytochem.2023.113922

Article  PubMed  CAS  Google Scholar 

Gu JP, Qi TZ, Zhu DR, He XJ, Guo SP, Lan X, Gu H, Luo JL, Yang M, Gu YC, Wang WL, Chen GT, Fan BY (2025) Isolation of pentasaccharide resin glycosides from the whole plants of Ipomoea biflora and their cytotoxic activities. Phytochemistry 236:114494. https://doi.org/10.1016/j.phytochem.2025.114494

Article  PubMed  CAS  Google Scholar 

Ono M, Kawakami G, Takigawa A, Kabata K, Okawa M, Kinjo J, Yokomizo K, Yoshimitsu H, Nohara T (2014) Calysolins X-XIII, resin glycosides from Calystegia soldanella, and their antiviral activity toward herpes simplex virus. Chem Pharm Bull 62:839–844

Article  CAS  Google Scholar 

Ono M, Tenmaya D, Tarumi M, Satou S, Tsuji K, Nishikawa H, Yasuda S, Miyashita H, Zhou JR, Yokomizo K (2024) Four new resin glycosides from Ipomoea muricata seeds: muricatins XIV–XVII. J Nat Med 78:525–536

Article  PubMed  CAS  Google Scholar 

Misuda N, Watanabe M, Nishikawa H, Yasuda S, Miyashita H, Yokomizo K, Yoshimitsu H, Tsuchihashi R, Okawa M, Kinjo J, Ono M (2025) Ten new resin glycosides, ipoalbins I–X, from Ipomoea alba seeds. J Nat Med 79:341–356. https://doi.org/10.1007/s11418-024-01868-1

Article  PubMed  CAS  Google Scholar 

O’Keefe S, Roboti P, Duah KB, Zong G, Schneider H, Shi WQ, High S (2021) Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor. J Cell Sci 134:jcs257758

Article  PubMed  PubMed Central  Google Scholar 

Yoshikawa K, Yagi C, Hama H, Tanaka M, Arihara S, Hashimoto T (2010) Ipomotaosides A – D, resin glycosides from the aerial parts of Ipomoea Batatas and their inhibitory activity against COX-1 and COX-2. J Nat Prod 73:1763–1766

Article  PubMed  CAS  Google Scholar 

Liu T, Zhang M, Xie Q, Gu J, Zeng S, Huang D (2025) Unveiling the antiobesity mechanism of sweet potato extract by microbiome, transcriptome, and metabolome analyses in mice. J Agric Food Chem 73:7807–7821. https://doi.org/10.1021/acs.jafc.4c13173

Article  PubMed  CAS  Google Scholar 

Liu T, Wu F, Chen K, Pan B, Yin X, You Y, Song Z, Li D, Huang D (2022) Sweet potato extract alleviates high-fat-diet-induced obesity in C57BL/6J mice, but not by inhibiting pancreatic lipases. Front Nutr 9:1016020. https://doi.org/10.3389/fnut.2022.1016020

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rosas-Ramírez D, Escandón-Rivera S, Pereda-Miranda R (2018) Morning glory resin glycosides as α-glucosidase inhibitors: In vitro and in silico analysis. Phytochemistry 148:39–47

Article  PubMed  Google Scholar 

Rosas-Ramírez D, Pereda-Miranda R, Escandón-Rivera S, Arreguín-Espinosa R (2020) Identification of α-glucosidase inhibitors from Ipomoea alba by affinity-directed fractionation-mass spectrometry. Rev Bras Farmacogn 30:336–345. https://doi.org/10.1007/s43450-020-00068-8

Article  CAS  Google Scholar 

Akash MSH, Afzaal A, Rehman K, Hussain A, Ibrahim M, Shoaib SM, Shahid M, Sadaf B (2024) Identification of secondary metabolites of Cyperus rotundus L. and dose-dependent effects on antioxidant activity and carbohydrate digestion enzymes. Dose Response 22:15593258241308724. https://doi.org/10.1177/15593258241308724

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rehman K, Chohan TA, Waheed I, Gilani Z, Akash MSH (2019) Taxifolin prevents postprandial hyperglycemia by regulating the activity of α-amylase: evidence from an in vivo and in silico studies. J Cell Biochem 120:425–438

Article  PubMed  CAS  Google Scholar 

Khalid MF, Rehman K, Irshad K, Chohan TA, Akash MSH (2022) Biochemical investigation of inhibitory activities of plant-derived bioactive compounds against carbohydrate and glucagon-like peptide-1 metabolizing enzymes. Dose Response 20:15593258221093275. https://doi.org/10.1177/15593258221093275

Article  PubMed  PubMed Central  CAS  Google Scholar 

Subramaniyan V, Hanim YU (2025) Role of pancreatic lipase inhibition in obesity treatment: mechanisms and challenges towards current insights and future directions. Int J Obes (Lond) 49:492–506. https://doi.org/10.1038/s41366-025-01729-1

Article  PubMed  PubMed Central  Google Scholar 

Nishikawa H, Sato R, Misuda N, Furumura H, Miyasaka T, Hirano M, Kinoshita H, Yoneda K, Ono M, Yasuda S (2025) In vitro lipase inhibition and in silico modelling analysis of the resin glycosides from the seeds of Ipomoea muricata and pharbitin from Pharbitidis Semen. Nat Prod Res. https://doi.org/10.1080/14786419.2025.2495162

Article  PubMed  Google Scholar 

Ado MA, Abas F, Mohammed AS, Ghazali HM (2013) Anti- and pro-lipase activity of selected medicinal, herbal and aquatic plants, and structure elucidation of an anti-lipase compound. Molecules 18:14651–14669

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gamboa-Gómez CI, Denise-Herrera M, Simental-Mendía LE, Zamilpa-Alvarez A, González-Cortazar M, Martínez-Aguilar G, Alvarado-Aguilar P, Morales-Castro EP, Ávila-Soto JA, Amador-Herrera JA (2022) Inhibitory effect of Mexican oregano (Lippia graveolens Kunth) extracts on digestive enzymes in vitro, and beneficial impact on carbohydrates and lipids absorption in vivo. J Ethnopharmacol 297:115527

Article  PubMed