Medicinal Plants and the Gastrointestinal Microbiota in Chronic Diseases Modulation: A Structured Mechanistic and Translational Review

Hacker K (2024) The Burden of Chronic Disease. Mayo Clin Proc Innov Qual Outcomes. 8:112–119. https://doi.org/10.1016/j.mayocpiqo.2023.08.005

Ugwu OP-C, Alum EU, Okon MB, Obeagu EI (2024) Mechanisms of microbiota modulation: Implications for health, disease, and therapeutic interventions. Medicine 103:e38088. https://doi.org/10.1097/MD.0000000000038088

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alum EU (2024) Climate change and its impact on the bioactive compound profile of medicinal plants: implications for global health. Plant Signal Behav 19:2419683. https://doi.org/10.1080/15592324.2024.2419683

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saini R, Sharma N, Oladeji OS, Sourirajan A, Dev K, Zengin G, El-Shazly M, Kumar V (2022) Traditional uses, bioactive composition, pharmacology, and toxicology of Phyllanthus emblica fruits: A comprehensive review. J Ethnopharmacol 282:114570. https://doi.org/10.1016/j.jep.2021.114570

Article  CAS  PubMed  Google Scholar 

Vignesh A, Amal TC, Selvakumar S, Vasanth K (2023) Unraveling the role of medicinal plants and Gut microbiota in colon cancer: Towards microbiota- based strategies for prevention and treatment. Health Sci Rev 9:100115. https://doi.org/10.1016/j.hsr.2023.100115

Article  Google Scholar 

Guan Y, Tang G, Li L, Shu J, Zhao Y, Huang L, Tang J (2024) Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management. Arch Pharm Res 47:146–164. https://doi.org/10.1007/s12272-023-01484-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Gou X, Ding Y, Liu J, Wang Y, Wang Y, Zhang J, Du L, Peng W, Fan G (2023) The interplay between herbal medicines and gut microbiota in metabolic diseases. Front Pharmacol 14. https://doi.org/10.3389/fphar.2023.1105405

Baethge C, Goldbeck-Wood S, Mertens S (2019) SANRA—a scale for the quality assessment of narrative review articles. Res Integr Peer Rev 4:5. https://doi.org/10.1186/s41073-019-0064-8

Article  PubMed  PubMed Central  Google Scholar 

Maciel-Fiuza MF, Muller GC, Campos DMS, do Socorro Silva Costa P, Peruzzo J, Bonamigo RR, Veit T, Vianna FSL (2023) Role of gut microbiota in infectious and inflammatory diseases. Front Microbiol 14. https://doi.org/10.3389/fmicb.2023.1098386

Holscher HD (2017) Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes 8:172–184. https://doi.org/10.1080/19490976.2017.1290756

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan J, Taitz J, Nanan R, Grau G, Macia L (2023) Dysbiotic Gut Microbiota-Derived Metabolites and Their Role in Non-Communicable Diseases. Int J Mol Sci 24:15256. https://doi.org/10.3390/ijms242015256

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh T, Kaur G, Kaur A (2023) Dysbiosis—An Etiological Factor for Cardiovascular Diseases and the Therapeutic Benefits of Gut Microflora. Advanced Gut & Microbiome Research. 7451554 (2023). https://doi.org/10.1155/2023/7451554

Alum EU, Nwali BU, Aniokete UC, Emeruwa AP, Obasi DC, Okoroh PN, Akwari AA, Nwuruku OA, Nzubechukwu E, Aja PM (2025) Gut microbiota at the crossroads of food additives, pollutants, and chronic disease risk. Toxicol Environ Health Sci 1–31. https://doi.org/10.1007/s13530-025-00295-3

Novakovic M, Rout A, Kingsley T, Kirchoff R, Singh A, Verma V, Kant R, Chaudhary R (2020) Role of gut microbiota in cardiovascular diseases. World J Cardiol 12:110–122. https://doi.org/10.4330/wjc.v12.i4.110

Article  PubMed  PubMed Central  Google Scholar 

Fu J, Zheng Y, Gao Y, Xu W (2022) Dietary Fiber Intake and Gut Microbiota in Human Health. Microorganisms 10:2507. https://doi.org/10.3390/microorganisms10122507

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alum EU, Obeagu EI, Ugwu OPC, Aja PM, Okon MB (2023) HIV Infection and Cardiovascular diseases: The obnoxious Duos. Newport Int J Res Med Sci 3(2):95–99

Google Scholar 

Grillo A, Salvi L, Coruzzi P, Salvi P, Parati G (2019) Sodium Intake Hypertens Nutrients 11:1970. https://doi.org/10.3390/nu11091970

Article  CAS  Google Scholar 

Xu H, Wang X, Feng W, Liu Q, Zhou S, Liu Q, Cai L (2020) The gut microbiota and its interactions with cardiovascular disease. Microb Biotechnol 13:637–656. https://doi.org/10.1111/1751-7915.13524

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao L, Harrison DG (2020) Inflammation in Hypertension. Can J Cardiol 36:635–647. https://doi.org/10.1016/j.cjca.2020.01.013

Article  PubMed  PubMed Central  Google Scholar 

Munno M, Mallia A, Greco A, Modafferi G, Banfi C, Eligini S (2024) Radical Oxygen Species, Oxidized Low-Density Lipoproteins, and Lectin-like Oxidized Low-Density Lipoprotein Receptor 1: A Vicious Circle in Atherosclerotic Process. Antioxidants 13:583. https://doi.org/10.3390/antiox13050583

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoo JY, Groer M, Dutra SVO, Sarkar A, McSkimming DI (2020) Gut Microbiota and Immune System Interactions. Microorganisms 8:1587. https://doi.org/10.3390/microorganisms8101587

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu X, Chen Y, Chen D (2020) The Role of Gut Microbiome in Autoimmune Uveitis. Ophthalmic Res 64:168–177. https://doi.org/10.1159/000510212

Article  CAS  PubMed  Google Scholar 

de Oliveira GLV (2019) Chap. 33 - The Gut Microbiome in Autoimmune Diseases. In: Faintuch J, Faintuch S (eds) Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications. Academic, pp 325–332

Mousa WK, Chehadeh F, Husband S (2022) Microbial dysbiosis in the gut drives systemic autoimmune diseases. Front Immunol 13. https://doi.org/10.3389/fimmu.2022.906258

Bielka W, Przezak A, Pawlik A (2022) The Role of the Gut Microbiota in the Pathogenesis of Diabetes. Int J Mol Sci 23:480. https://doi.org/10.3390/ijms23010480

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Watanabe K, Kimura I (2017) Gut Microbiota Dysbiosis Drives and Implies Novel Therapeutic Strategies for Diabetes Mellitus and Related Metabolic Diseases. Front Immunol 8. https://doi.org/10.3389/fimmu.2017.01882

Sharma S, Tripathi P (2019) Gut microbiome and type 2 diabetes: where we are and where to go? J Nutr Biochem 63:101–108. https://doi.org/10.1016/j.jnutbio.2018.10.003

Article  CAS  PubMed  Google Scholar 

Thorakkattu P, Khanashyam AC, Shah K, Babu KS, Mundanat AS, Deliephan A, Deokar GS, Santivarangkna C, Nirmal NP (2022) Postbiotics: Current Trends in Food and Pharmaceutical Industry. Foods 11:3094. https://doi.org/10.3390/foods11193094

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gong X, Li X, Bo A, Shi R-Y, Li Q-Y, Lei L-J, Zhang L, Li M-H (2020) The interactions between gut microbiota and bioactive ingredients of traditional Chinese medicines: A review. Pharmacol Res 157:104824. https://doi.org/10.1016/j.phrs.2020.104824

Article  CAS  PubMed  Google Scholar 

Adehin A, Igbinoba SI, Soyinka JO, Onyeji CO, Babalola CP, Bolaji OO (2019) Pharmacokinetic Parameters of Quinine in Healthy Subjects and in Patients with Uncomplicated Malaria in Nigeria: Analysis of Data using a Population Approach. Curr Ther Res Clin Exp 91:33–38. https://doi.org/10.1016/j.curtheres.2019.100567

Article  PubMed  PubMed Central  Google Scholar 

Banc R, Rusu ME, Filip L, Popa D-S (2023) The Impact of Ellagitannins and Their Metabolites through Gut Microbiome on the Gut Health and Brain Wellness within the Gut–Brain Axis. Foods 12:270. https://doi.org/10.3390/foods12020270

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faitg J, D’Amico D, Rinsch C, Singh A (2023) Mitophagy Activation by Urolithin A to Target Muscle Aging. Calcif Tissue Int 114(1):53–59. https://doi.org/10.1007/s00223-023-01145-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Denk D, Singh A, Kasler HG, D’Amico D, Rey J, Alcober-Boquet L, Gorol JM, Steup C, Tiwari R, Kwok R, Argüello RJ, Faitg J, Sprinzl K, Zeuzem S, Nekljudova V, Loibl S, Verdin E, Rinsch C, Greten FR (2025) Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial. Nat Aging 5:2309–2322. https://doi.org/10.1038/s43587-025-00996-x

Article  CAS  PubMed  PubMed Central 

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