Bone Marrow Mesenchymal Stem Cell Preconditioning With Alpha Pinene Reverses Ischemia Induced Neuronal Degeneration in Rats

Stuckey SM, Ong LK, Collins-Praino LE, Turner RJ. Neuroinflammation as a key driver of secondary neurodegeneration following stroke? Int J Mol Sci. 2021;22(23):13101.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feigin, V. L., Brainin, M., Norrving, B., Martins, S. O., Pandian, J., Lindsay, P., & Rautalin, I. World Stroke Organization: Global Stroke Fact Sheet 2025. Int J Stroke. 2025;17474930241308142.

Onose G, Anghelescu A, Blendea D, Ciobanu V, Daia C, Firan FC, et al. Cellular and molecular targets for non-invasive, non-pharmacological therapeutic/rehabilitative interventions in acute ischemic stroke. Int J Mol Sci. 2022;23(2):907.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Capirossi C, Laiso A, Renieri L, Capasso F, Limbucci N. Epidemiology, organization, diagnosis and treatment of acute ischemic stroke. Eur J Radiol Open. 2023;11:100527.

Article  PubMed  PubMed Central  Google Scholar 

Pottoo FH, Ibrahim AM, Alammar A, Alsinan R, Aleid M, Alshehhi A, et al. Thymoquinone: review of its potential in the treatment of neurological diseases. Pharmaceuticals. 2022;15(4):408.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salaudeen MA, Bello N, Danraka RN, Ammani ML. Understanding the pathophysiology of ischemic stroke: the basis of current therapies and opportunity for new ones. Biomolecules. 2024;14(3):305.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Capitanescu B, Hermann DM, Surugiu R, Guzman R, Olaru DG, Popa-Wagner A. Advances in brain remodeling, stem cell therapies, and translational barriers in stroke and brain aging. Biogerontology. 2025;26(4):143.

Article  PubMed  PubMed Central  Google Scholar 

Cui C, Jiang X, Wang Y, Li C, Lin Z, Wei Y, et al. Cerebral hypoxia-induced molecular alterations and their impact on the physiology of neurons and dendritic spines: a comprehensive review. Cell Mol Neurobiol. 2024;44(1):58.

Article  PubMed  PubMed Central  Google Scholar 

Berlet R, Anthony S, Brooks B, Wang ZJ, Sadanandan N, Shear A, et al. Combination of stem cells and rehabilitation therapies for ischemic stroke. Biomolecules. 2021;11(9):1316.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shehjar F, Maktabi B, Rahman ZA, Bahader GA, James AW, Naqvi A, et al. Stroke: molecular mechanisms and therapies: update on recent developments. Neurochem Int. 2023;162:105458.

Article  CAS  PubMed  Google Scholar 

Yamagishi H, Shigematsu K. Perspectives on stem cell-based regenerative medicine with a particular emphasis on mesenchymal stem cell therapy. JMA J. 2021;5(1):36–43.

Article  PubMed  PubMed Central  Google Scholar 

Lin YY, Chuang DM, Chi CY, Hung SY. Intranasal administration of mesenchymal stem cells overexpressing FGF21 demonstrates therapeutic potential in experimental Parkinson’s disease. Neurotherapeutics. 2025;22(2):e00501.

Article  PubMed  Google Scholar 

Ocansey DKW, Pei B, Yan Y, Qian H, Zhang X, Xu W, et al. Improved therapeutics of modified mesenchymal stem cells: an update. J Transl Med. 2020;18(1):1–14.

Article  Google Scholar 

Wu C, Huang Z, Chen J, Li N, Cai Y, Chen J, et al. Efficiently directing differentiation and homing of mesenchymal stem cells to boost cartilage repair in osteoarthritis via a nanoparticle and peptide dual-engineering strategy. Biomaterials. 2025;312:122720.

Article  CAS  PubMed  Google Scholar 

Masnoon J, Ishaque A, Khan I, Salim A, Kabir N. Effect of lawsonepreconditioned mesenchymal stem cells on the regeneration of pancreatic β cells in Type 1 diabetic rats. Cell Biochem Funct. 2023;41(7):833–44.

Article  CAS  PubMed  Google Scholar 

Feng X, Zhang H, Yang S, Cui D, Wu Y, Qi X, et al. From stem cells to pancreatic β-cells: strategies, applications, and potential treatments for diabetes. Mol Cell Biochem. 2025;480(1):173–90.

Article  CAS  PubMed  Google Scholar 

Zhong X, Luo L, Wu J, Li W, Liu X, Ye T, et al. Adhesion-assisted antioxidant-engineered mesenchymal stromal cells for enhanced cardiac repair in myocardial infarction. ACS Nano. 2025;19(11):11412–26.

Article  CAS  PubMed  Google Scholar 

An W, Zhang W, Qi J, Xu W, Long Y, Qin H, et al. Mesenchymal stem cells and mesenchymal stem cell-derived exosomes: a promising strategy for treating retinal degenerative diseases. Mol Med. 2025;31(1):75.

Article  CAS  PubMed  Google Scholar 

Uyama H, Mandai M, Takahashi M. Stem-cell‐based therapies for retinal degenerative diseases: current challenges in the establishment of new treatment strategies. Dev Growth Differ. 2021;63(1):59–71.

Article  PubMed  PubMed Central  Google Scholar 

Chen S, Han C, Shi Z, Guan X, Cheng L, Wang L, et al. Umbilical mesenchymal stem cells mitigate T-cell compartments shift and Th17/Treg imbalance in acute ischemic stroke via mitochondrial transfer. Stem Cell Res Ther. 2025;16(1):1–24.

Google Scholar 

Sivandzade F, Cucullo L. Regenerative stem cell therapy for neurodegenerative diseases: an overview. Int J Mol Sci. 2021;22(4):2153.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chrostek MR, Fellows EG, Crane AT, Grande AW, Low WC. Efficacy of stem cell-based therapies for stroke. Brain Res. 2019;1722:146362.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernandez-Susavila H, Bugallo-Casal A, Castillo J, Campos F. Adult stem cells and induced pluripotent stem cells for stroke treatment. Front Neurol. 2019. https://doi.org/10.3389/fneur.2019.00908.

Article  PubMed  PubMed Central  Google Scholar 

Scopetti M, Santurro A, Gatto V, La Russa R, Manetti F, D’Errico S, et al. Mesenchymal stem cells in neurodegenerative diseases: opinion review on ethical dilemmas. World J Stem Cells. 2020;12(3):168.

Article  PubMed  PubMed Central  Google Scholar 

Wang F, Tang H, Zhu J, Zhang JH. Transplanting mesenchymal stem cells for treatment of ischemic stroke. Cell Transplant. 2018;27(12):1825–34.

Article  PubMed  PubMed Central  Google Scholar 

Alhazzani A, Rajagopalan P, Albarqi Z, Devaraj A, Mohamed MH, Al-Hakami A, et al. Mesenchymal stem cells (MSCs) coculture protects [Ca2+]i orchestrated oxidant mediated damage in differentiated neurons in vitro. Cells. 2018;7(12):250.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He J, Liu J, Huang Y, Zhuo Y, Chen W, Duan D, et al. Olfactory mucosa mesenchymal stem cells alleviate cerebral ischemia/reperfusion injury via Golgi apparatus secretory pathway Ca2+-ATPase isoform1. Front Cell Dev Biol. 2020;8:586541.

Article  PubMed  Google Scholar 

Liu J, Huang Y, He J, Zhuo Y, Chen W, Ge L, et al. Olfactory mucosa mesenchymal stem cells ameliorate cerebral ischemic/reperfusion injury through modulation of UBIAD1 expression. Front Cell Neurosci. 2020;14:580206.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rashed LA, Elattar S, Eltablawy N, Ashour H, Mahmoud LM, El-Esawy Y. Mesenchymal stem cells pretreated with melatonin ameliorate kidney functions in a rat model of diabetic nephropathy. Biochem Cell Biol. 2018;96(5):564–71.

Article  CAS  PubMed  Google Scholar 

Hingert D, Barreto Henriksson H, Brisby H. Human mesenchymal stem cells pretreated with interleukin-1β and stimulated with bone morphogenetic growth factor-3 enhance chondrogenesis. Tissue Eng Part A. 2018;24(9–10):775–85.

Article  CAS  PubMed  Google Scholar 

Qazi TH, Mooney DJ, Duda GN, Geissler S. Biomaterials that promote cell-cell interactions enhance the paracrine function of MSCs. Biomaterials. 2017;140:103–14.

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