Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare, making up less than 0.5% of all NETs. The liver is a common site for metastatic NET, leading to challenges in determining if a neuroendocrine neoplasm located in the liver is primary or metastatic. We report two cases of patients diagnosed with PHNETs. They were first misdiagnosed, the first case as liver hamartoma and the treatment was delayed for 4 years and the second case was first diagnosed as hepatocellular carcinoma. Although rare, the possibility of primary hepatic neuroendocrine neoplasms should be considered for a solid-cystic mass in a young patient with no known chronic liver disease and without any known primary malignancy elsewhere. Surgical resection is the most effective and reliable treatment method for patients with PHNET.
primary hepatic neuroendocrine tumor (PHNET) - neuroendocrine tumor (NET) - hepatectomyCase report approved for publishing by ethical committee at Saint George Hospital University Medical Center, and Head of General Surgery division.
© 2026. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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Bibliographical Record
Souad Ghattas, Hani Maalouf, Jad El Bitar, Raghid Issa, Ribal Aby Hadeer, Wissam Dib, Antoine El Asmar, Hind Rahban, Ziad El Rassi. Two Rare Cases of Primary Hepatic Neuroendocrine Tumors: Case Reports and Literature
Review. Surg J (N Y) 2026; 12: a28470213.
DOI: 10.1055/a-2847-0213
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