Al-Nerabieah Z, AlKhouli M, Dashash M. Preventive efficacy of 38% silver diamine fluoride and cpp-acp fluoride varnish on molars affected by molar incisor hypomineralization in children: a randomized controlled trial. F1000Res. 2024;12:1052. https://doi.org/10.12688/f1000research.136653.3.
Article PubMed PubMed Central Google Scholar
Ammar N, Fresen KF, Schwendicke F, Kuhnisch J. Epidemiological trends in enamel hypomineralisation and molar-incisor hypomineralisation: a systematic review and meta-analysis. Clin Oral Investig. 2025;29(6):327. https://doi.org/10.1007/s00784-025-06411-4.
Article PubMed PubMed Central Google Scholar
Ballikaya E, Unverdi GE, Cehreli ZC. Management of initial carious lesions of hypomineralized molars (MIH) with silver diamine fluoride or silver-modified atraumatic restorative treatment (SMART): 1-year results of a prospective, randomized clinical trial. Clin Oral Investig. 2022;26(2):2197–205. https://doi.org/10.1007/s00784-021-04236-5.
Baraka M, Elwardani G, Hamed H, Zeitoun SI. Management of hypersensitivity in molar incisor hypomineralisation using photobiomodulation and sealants in children: a randomized clinical trial. J Evid Based Dent Pract. 2025;25(3):102159. https://doi.org/10.1016/j.jebdp.2025.102159.
Butera A, Gallo S, Pascadopoli M, Montasser MA, Abd El Latief MH, Modica GG, et al. Home oral care with biomimetic hydroxyapatite vs. conventional fluoridated toothpaste for the remineralization and desensitizing of white spot lesions: randomized clinical trial. Int J Environ Res Public Health. 2022. https://doi.org/10.3390/ijerph19148676.
Article PubMed PubMed Central Google Scholar
Cerqueira NM, Altube LG, Gambarini L, Borsatto MC, Corona SAM. Laser therapy in molar-incisor hypomineralization (MIH) teeth treatment of hypersensitivity: a systematic review. Lasers Med Sci. 2025;40(1):11. https://doi.org/10.1007/s10103-024-04280-z.
Chan AKY, Tsang YC, Yu OY, Lo ECM, Leung KCM, Chu CH. Clinical evidence for silver diamine fluoride to reduce dentine hypersensitivity: a systematic review. J Dent. 2024;142:104868. https://doi.org/10.1016/j.jdent.2024.104868.
Article CAS PubMed Google Scholar
Chatzidimitriou K, Theodorou K, Seremidi K, Kloukos D, Gizani S, Papaioannou W. The role of hydroxyapatite-based, fluoride-free toothpastes on the prevention and the remineralization of initial caries lesions: a systematic review and meta-analysis. J Dent. 2025;156:105691. https://doi.org/10.1016/j.jdent.2025.105691.
Article CAS PubMed Google Scholar
Cochrane NJ, Reynolds EC. Calcium phosphopeptides — mechanisms of action and evidence for clinical efficacy. Adv Dent Res. 2012;24(2):41–7. https://doi.org/10.1177/0022034512454294.
Article CAS PubMed Google Scholar
Ehlers V, Reuter AK, Kehl EB, Enax J, Meyer F, Schlecht J, et al. Efficacy of a toothpaste based on microcrystalline hydroxyapatite on children with hypersensitivity caused by mih: a randomised controlled trial. Oral Health Prev Dent. 2021;19(1):647–58. https://doi.org/10.3290/j.ohpd.b2403649.
Article PubMed PubMed Central Google Scholar
Elhennawy K, Rajjoub O, Reissmann DR, Doueiri MS, Hamad R, Sierwald I, et al. The association between molar incisor hypomineralization and oral health-related quality of life: a cross-sectional study. Clin Oral Investig. 2022;26(5):4071–7. https://doi.org/10.1007/s00784-022-04375-3.
Article CAS PubMed PubMed Central Google Scholar
Fagrell TG, Lingstrom P, Olsson S, Steiniger F, Noren JG. Bacterial invasion of dentinal tubules beneath apparently intact but hypomineralized enamel in molar teeth with molar incisor hypomineralization. Int J Paediatr Dent. 2008;18(5):333–40. https://doi.org/10.1111/j.1365-263X.2007.00908.x.
FDI. FDI policy statement on oral health and quality of life: Adopted by the FDI general assembly: 24 September 2015, Bangkok, Thailand. Int Dent J. 2016;66(1):11–2. https://doi.org/10.1111/idj.12233.
Gaballah R, Amend S, Fresen KF, Schill H, Michel R, Pitchika V, et al. Hypersensitivity associated with molar-incisor hypomineralisation (MIH) among elementary schoolchildren in Bavaria, Germany: results from a cross-sectional study. Eur Arch Paediatr Dent. 2025;26(5):987–96. https://doi.org/10.1007/s40368-025-01054-1.
Article CAS PubMed PubMed Central Google Scholar
Gadallah LK, Korayem E, Wahby R. Oral health-related quality of life in Egyptian children with molar incisor hypomineralisation. An observational study. BDJ Open. 2024;10(1):89. https://doi.org/10.1038/s41405-024-00272-x.
Article PubMed PubMed Central Google Scholar
Gao SS, Zhang S, Mei ML, Lo EC, Chu CH. Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic review. BMC Oral Health. 2016;16:12. https://doi.org/10.1186/s12903-016-0171-6.
Article CAS PubMed PubMed Central Google Scholar
Guyatt G, Agoritsas T, Brignardello-Petersen R, Mustafa RA, Rylance J, Foroutan F, et al. Core grade 1: overview of the core grade approach. BMJ. 2025;389:e081903. https://doi.org/10.1136/bmj-2024-081903.
Haque Afzal S, Wigen TI, Skaare AB, Brusevold IJ. Molar-incisor hypomineralisation in Norwegian children: prevalence and associated factors. Eur J Oral Sci. 2023. https://doi.org/10.1111/eos.12930.
Hjertberg E, Hajdarević A, Jälevik B. Desensitization treatment in mih-affected teeth: a systematic review. Eur Arch Paediatr Dent. 2025;26(1):17–29. https://doi.org/10.1007/s40368-024-00934-2.
Jalevik B, Sabel N, Robertson A. Can molar incisor hypomineralization cause dental fear and anxiety or influence the oral health-related quality of life in children and adolescents?-a systematic review. Eur Arch Paediatr Dent. 2021. https://doi.org/10.1007/s40368-021-00631-4.
Article PubMed PubMed Central Google Scholar
Lygidakis NA, Garot E, Somani C, Taylor GD, Rouas P, Wong FSL. Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document. Eur Arch Paediatr Dent. 2022;23(1):3–21. https://doi.org/10.1007/s40368-021-00668-5.
Article CAS PubMed Google Scholar
Mahfouz RA, Hanno AG, Rahman A. Zirconia-reinforced glass ionomer restorations in molar incisor hypomineralization: a randomized controlled clinical trial. Clin Oral Investig. 2025;29(6):290. https://doi.org/10.1007/s00784-025-06352-y.
Article PubMed PubMed Central Google Scholar
Nørrisgaard PE, Haubek D, Schoos AM, Kühnisch J, Chawes BL, Stokholm J, et al. Asthma medication and risk of dental diseases in children - a prospective cohort study. Pediatr Allergy Immunol. 2023;34(10):e14026. https://doi.org/10.1111/pai.14026.
Article CAS PubMed Google Scholar
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://doi.org/10.1136/bmj.n71.
Article PubMed PubMed Central Google Scholar
Poulsen S, Errboe M, Lescay Mevil Y, Glenny AM. Potassium containing toothpastes for dentine hypersensitivity. Cochrane Database Syst Rev. 2006;2006(3):Cd001476. https://doi.org/10.1002/14651858.CD001476.pub2.
Article PubMed PubMed Central Google Scholar
Reissenberger T, Ebel M, Klode C, Hirsch C, Bekes K. Hypomineralized teeth and their impact on oral-health-related quality of life in primary school children. Int J Environ Res Public Health. 2022. https://doi.org/10.3390/ijerph191610409.
Article PubMed PubMed Central Google Scholar
Rhaiem M, Chatti M, Elelmi Y, Ben Haj Khalifa A, Masmoudi F, Baaziz A. Effective anaesthesia when treating teeth affected by molar incisor hypomineralisation (MIH): a systematic review. Eur Arch Paediatr Dent. 2025;26(5):861–76. https://doi.org/10.1007/s40368-025-01057-y.
Rodd HD, Morgan CR, Day PF, Boissonade FM. Pulpal expression of TRPV1 in molar incisor hypomineralisation. Eur Arch Paediatr Dent. 2007;8(4):184–8. https://doi.org/10.1007/bf03262594.
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