Analysis of quantitative OCT and SS-OCTA metrics three months after initiation of intravitreal faricimab for treatment-recalcitrant neovascular AMD

Finger RP, Daien V, Eldem BM, Talks JS, Korobelnik JF, Mitchell P, et al. Anti-vascular endothelial growth factor in neovascular age-related macular degeneration - a systematic review of the impact of anti-VEGF on patient outcomes and healthcare systems. BMC Ophthalmol. 2020;20:294.

Article  PubMed  PubMed Central  Google Scholar 

Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014;2:e106–16.

Article  PubMed  Google Scholar 

Stanga PE, Valentín-Bravo FJ, Stanga SEF, Reinstein UI, Pastor-Idoate S, Downes SM. Faricimab in neovascular AMD: first report of real-world outcomes in an independent retina clinic. Eye. 2023;37:3282–3289.

Zuber-Laskawiec K, Kubicka-Trzaska A, Karska-Basta I, Pociej-Marciak W, Romanowska-Dixon B. Non-responsiveness and tachyphylaxis to anti-vascular endothelial growth factor treatment in naive patients with exudative age-related macular degeneration. J Physiol Pharmacol. 2019;70:779–785.

Nair AA, Finn AP, Sternberg P Jr. Spotlight on faricimab in the treatment of wet age-related macular degeneration: design, development and place in therapy. Drug Des Devel Ther. 2022;16:3395–400.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Regula JT, Lundh von Leithner P, Foxton R, Barathi VA, Gemmy Cheung CM, Bo Tun SB, et al. Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases. EMBO Mol Med. 2017;9:985.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khanani AM, Aziz AA, Khan H, Gupta A, Mojumder O, Saulebayeva A, et al. The real-world efficacy and safety of faricimab in neovascular age-related macular degeneration: the TRUCKEE study - 6 month results. Eye. 2023;37:3574–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pandit SA, Momenaei B, Wakabayashi T, Mansour HA, Vemula S, Durrani AF, et al. Real-world outcomes of faricimab in patients with previously treated neovascular age-related macular degeneration. Ophthalmol Retina. 2024;8:360–366.

Borkar DS, Tabano D, Garmo V, Shaia JK, Kuo B, Myers R, et al. FARETINA-AMD- early treatment patterns and outcomes in patients with neovascular age-related macular degeneration initiating faricimab: an IRIS registryTM analysis. Invest Ophthalmol Vis Sci. 2023;64:2218.

Google Scholar 

Kanesa-Thasan A, Grewal DS, Gill MK, Lyon AT, Mirza RG. Quantification of change in pigment epithelial detachment volume and morphology after transition to intravitreal aflibercept in eyes with recalcitrant neovascular AMD: 18-month results. Ophthalmic Surg Lasers Imaging Retin. 2015;46:638–41.

Article  Google Scholar 

Major JC Jr, Wykoff CC, Croft DE, Wang R, Mariani AF, Lehmann AE, et al. Aflibercept for pigment epithelial detachment for previously treated neovascular age-related macular degeneration. Can J Ophthalmol. 2015;50:373–7.

Article  PubMed  Google Scholar 

Parravano M, Borrelli E, Sacconi R, Costanzo E, Marchese A, Manca D, et al. A comparison among different automatically segmented slabs to assess neovascular AMD using swept source OCT angiography. Transl Vis Sci Technol. 2019;8:8.

Article  PubMed  PubMed Central  Google Scholar 

Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012;9:676–82.

Article  CAS  PubMed  Google Scholar 

Huang L-K, Wang M-JJ. Image thresholding by minimizing the measures of fuzziness. Pattern Recognit. 1995;28:41–51.

Article  Google Scholar 

Pajula J, Kauppi JP, Tohka J. Inter-subject correlation in fMRI: method validation against stimulus-model based analysis. PLoS ONE. 2012;7:e41196.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pilotto E, Frizziero L, Daniele AR, Convento E, Longhin E, Guidolin F, et al. Early OCT angiography changes of type 1 CNV in exudative AMD treated with anti-VEGF. Br J Ophthalmol. 2019;103:67–71.

Article  PubMed  Google Scholar 

Takeuchi J, Kataoka K, Ito Y, Takayama K, Yasuma T, Kaneko H, et al. Optical coherence tomography angiography to quantify choroidal neovascularization in response to aflibercept. Ophthalmologica. 2018;240:90–8.

Article  CAS  PubMed  Google Scholar 

Faatz H, Farecki ML, Rothaus K, Gutfleisch M, Pauleikhoff D, Lommatzsch A. Changes in the OCT angiographic appearance of type 1 and type 2 CNV in exudative AMD during anti-VEGF treatment. BMJ Open Ophthalmol. 2019;4:e000369.

Article  PubMed  PubMed Central  Google Scholar 

Huang J, Huang J, Chen Y, Ying GS. Evaluation of approaches to analyzing continuous correlated eye data when sample size is small. Ophthalmic Epidemiol. 2018;25:45–54.

Article  PubMed  Google Scholar 

Comments (0)

No login
gif