Lin, X., Xiao, Z., Chen, T., Liang, S. H. & Guo, H. Glucose metabolism on tumor plasticity, diagnosis, and treatment. Front. Oncol. 10, 317 (2020).

PubMed  PubMed Central  Google Scholar 

Hay, N. Reprogramming glucose metabolism in cancer: Can it be exploited for cancer therapy? Nat. Rev. Cancer 16, 635–649 (2016).

CAS  PubMed  PubMed Central  Google Scholar 

Liberti, M. V. & Locasale, J. W. The Warburg effect: How does it benefit cancer cells? Trends Biochem. Sci. 41, 211–218 (2016).

CAS  PubMed  PubMed Central  Google Scholar 

Nagarajan, S. R., Butler, L. M. & Hoy, A. J. The diversity and breadth of cancer cell fatty acid metabolism. Cancer Metab. 9, 2 (2021).

PubMed  PubMed Central  Google Scholar 

Palm, W. & Thompson, C. B. Nutrient acquisition strategies of mammalian cells. Nature 546, 234–242 (2017).

CAS  PubMed  PubMed Central  Google Scholar 

DeWaal, D. et al. Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin. Nat. Commun. 9, 446 (2018).

PubMed  PubMed Central  Google Scholar 

Chan, D. A. et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci. Transl. Med. 3, 94ra70 (2011).

CAS  PubMed  PubMed Central  Google Scholar 

Liu, Y. et al. A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol. Cancer Ther. 11, 1672–1682 (2012).

CAS  PubMed  Google Scholar 

Fernandez, L. P., Gomez de Cedron, M. & Ramirez de Molina, A. Alterations of lipid metabolism in cancer: implications in prognosis and treatment. Front. Oncol. 10, 577420 (2020).

PubMed  PubMed Central  Google Scholar 

Khan, W. et al. Lipid metabolism in cancer: a systematic review. J. Carcinog. 20, 4 (2021).

CAS  PubMed  PubMed Central  Google Scholar 

Wang, W., Bai, L., Li, W. & Cui, J. The lipid metabolic landscape of cancers and new therapeutic perspectives. Front. Oncol. 10, 605154 (2020).

PubMed  PubMed Central  Google Scholar 

Snaebjornsson, M. T., Janaki-Raman, S. & Schulze, A. Greasing the wheels of the cancer machine: the role of lipid metabolism in cancer. Cell Metab. 31, 62–76 (2020).

CAS  PubMed  Google Scholar 

Mason, P. et al. SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PLoS ONE 7, e33823 (2012).

CAS  PubMed  PubMed Central  Google Scholar 

Guseva, N. V., Rokhlin, O. W., Glover, R. A. & Cohen, M. B. TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status. Cancer Biol. Ther. 12, 80–85 (2011).

CAS  PubMed  Google Scholar 

Seki, T. et al. Brown-fat-mediated tumour suppression by cold-altered global metabolism. Nature 608, 421–428 (2022).

CAS  PubMed  PubMed Central  Google Scholar 

Symonds, M. E., Aldiss, P., Pope, M. & Budge, H. Recent advances in our understanding of brown and beige adipose tissue: the good fat that keeps you healthy. F1000Res 7, F1000 (2018).

PubMed  PubMed Central  Google Scholar 

Virtanen, K. A. et al. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360, 1518–1525 (2009).

CAS  PubMed  Google Scholar 

Cannon, B. & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277–359 (2004).

CAS  PubMed  Google Scholar 

Klingenberg, M. Uncoupling protein—a useful energy dissipator. J. Bioenerg. Biomembr. 31, 419–430 (1999).

CAS  PubMed  Google Scholar 

Suzuki, D., Murata, Y. & Oda, S. Changes in Ucp1, D2 (Dio2) and Glut4 (Slc2a4) mRNA expression in response to short-term cold exposure in the house musk shrew (Suncus murinus). Exp. Anim. 56, 279–288 (2007).

CAS  PubMed  Google Scholar 

Vimaleswaran, K. S., Radha, V., Deepa, R. & Mohan, V. Absence of association of metabolic syndrome with PPARGC1A, PPARG and UCP1 gene polymorphisms in Asian Indians. Metab. Syndr. Relat. Disord. 5, 153–162 (2007).

CAS  PubMed  Google Scholar 

Feldmann, H. M., Golozoubova, V., Cannon, B. & Nedergaard, J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 9, 203–209 (2009).

CAS  PubMed  Google Scholar 

Tabuchi, C. & Sul, H. S. Corrigendum: signaling pathways regulating thermogenesis. Front. Endocrinol. (Lausanne) 12, 698619 (2021).

PubMed  Google Scholar 

Yi, D. et al. Zc3h10 acts as a transcription factor and is phosphorylated to activate the thermogenic program. Cell Rep. 29, 2621–2633.e4 (2019).

CAS  PubMed  PubMed Central  Google Scholar 

Puigserver, P. & Spiegelman, B. M. Peroxisome proliferator–activated receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator. Endocr. Rev. 24, 78–90 (2003).

CAS  PubMed  Google Scholar 

Lin, J. et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice. Cell 119, 121–135 (2004).

CAS  PubMed  Google Scholar 

Kajimura, S. Promoting brown and beige adipocyte biogenesis through the PRDM16 pathway. Int. J. Obes. Suppl. 5, S11–S14 (2015).

CAS  PubMed  PubMed Central  Google Scholar 

Harms, M. J. et al. PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program. Genes Dev. 29, 298–307 (2015).

CAS  PubMed  PubMed Central  Google Scholar 

Ohno, H., Shinoda, K., Spiegelman, B. M. & Kajimura, S. PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 15, 395–404 (2012).

CAS  PubMed  PubMed Central  Google Scholar 

Kajimura, S. et al. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-β transcriptional complex. Nature 460, 1154–1158 (2009).

CAS  PubMed  PubMed Central  Google Scholar 

Seale, P. et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 454, 961–967 (2008).

CAS  PubMed  PubMed Central  Google Scholar 

Kajimura, S. et al. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 22, 1397–1409 (2008).

CAS  PubMed  PubMed Central  Google Scholar 

Seale, P. et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 6, 38–54 (2007).

CAS  PubMed  PubMed Central  Google Scholar 

Wang, C. H. et al. CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Sci. Transl. Med. 12, eaaz8664 (2020).

CAS  PubMed  PubMed Central  Google Scholar 

Nwosu, Z. C. et al. Uridine-derived ribose fuels glucose-restricted pancreatic cancer. Nature 618, 151–158 (2023).

CAS  PubMed  PubMed Central  Google Scholar 

Kim, H. K. et al. Deep learning improves prediction of CRISPR-Cpf1 guide RNA activity. Nat. Biotechnol. 36, 239–241 (2018).

CAS  PubMed  Google Scholar 

Flint, J. & Shenk, T. Viral transactivating proteins. Annu. Rev. Genet. 31, 177–212 (1997).

CAS