Steinman, R. M. & Cohn, Z. A. Identification of a novel cell type in peripheral lymphoid organs of mice. J. Exp. Med. 137, 1142–1162 (1973).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cabeza-Cabrerizo, M., Cardoso, A., Minutti, C. M., da Costa, M. P. & Sousa, C. R. E. Dendritic cells revisited. Annu. Rev. Immunol. 39, 131–166 (2021).

Article  CAS  PubMed  Google Scholar 

Merad, M., Sathe, P., Helft, J., Miller, J. & Mortha, A. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu. Rev. Immunol. 31, 563–604 (2013).

Article  CAS  PubMed  Google Scholar 

Rakoff-Nahoum, S. & Medzhitov, R. Toll-like receptors and cancer. Nat. Rev. Cancer 9, 57–63 (2009).

Article  CAS  PubMed  Google Scholar 

Prete, A. D. et al. Dendritic cell subsets in cancer immunity and tumor antigen sensing. Cell. Mol. Immunol. 20, 432–447 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Dalod, M., Chelbi, R., Malissen, B. & Lawrence, T. Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming. EMBO J. 33, 1104–1116 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao, L. L. & Kagan, J. C. Targeting innate immune pathways for cancer immunotherapy. Immunity 56, 2206–2217 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fitzgerald, K. A. & Kagan, J. C. Toll-like receptors and the control of immunity. Cell 180, 1044–1066 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wculek, S. K. et al. Dendritic cells in cancer immunology and immunotherapy. Nat. Rev. Immunol. 20, 7–24 (2020).

Article  CAS  PubMed  Google Scholar 

Salmon, H. et al. Expansion and activation of CD103+ dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition. Immunity 44, 924–938 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roberts, E. W. et al. Critical role for CD103+/CD141+ dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma. Cancer Cell 30, 324–336 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sánchez-Paulete, A. R. et al. Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires BATF3-dependent dendritic cells. Cancer Discov. 6, 71–79 (2016).

Article  PubMed  Google Scholar 

Mellman, I. & Steinman, R. M. Dendritic cells specialized and regulated antigen processing machines. Cell 106, 255–258 (2001).

Article  CAS  PubMed  Google Scholar 

Sousa, C. R. e. Dendritic cells in a mature age. Nat. Rev. Immunol. 6, 476–483 (2006).

Article  Google Scholar 

Pittet, M. J., Pilato, M. D., Garris, C. & Mempel, T. R. Dendritic cells as shepherds of T cell immunity in cancer. Immunity 56, 2218–2230 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mellman, I., Chen, D. S., Powles, T. & Turley, S. J. The cancer-immunity cycle: indication, genotype, and immunotype. Immunity 56, 2188–2205 (2023).

Article  CAS  PubMed  Google Scholar 

Broz, M. L. et al. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell 26, 638–652 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Engelhardt, J. J. et al. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell 21, 402–417 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spranger, S., Dai, D., Horton, B. & Gajewski, T. F. Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy. Cancer Cell 31, 711–723.e4 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Böttcher, J. P. et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control. Cell 172, 1022–1037.e14 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Brown, C. C. et al. Transcriptional basis of mouse and human dendritic cell heterogeneity. Cell 179, 846–863.e24 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodrigues, P. F. et al. Progenitors of distinct lineages shape the diversity of mature type 2 conventional dendritic cells. Immunity 57, 1567–1585.e5 (2024).

Article  CAS  PubMed  Google Scholar 

Lewis, K. L. et al. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity 35, 780–791 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tussiwand, R. et al. Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity 42, 916–928 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Minutti, C. M. et al. Distinct ontogenetic lineages dictate cDC2 heterogeneity. Nat. Immunol. 25, 448–461 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Binnewies, M. et al. Unleashing type-2 dendritic cells to drive protective antitumor CD4+ T cell immunity. Cell 177, 556–571.e16 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kvedaraite, E. & Ginhoux, F. Human dendritic cells in cancer. Sci. Immunol. 7, eabm9409 (2022).

Article  CAS  PubMed  Google Scholar 

Schlitzer, A., McGovern, N. & Ginhoux, F. Dendritic cells and monocyte-derived cells: two complementary and integrated functional systems. Semin. Cell Dev. Biol. 41, 9–22 (2015).

Article  CAS  PubMed  Google Scholar 

León, B., López-Bravo, M. & Ardavín, C. Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against leishmania. Immunity 26, 519–531 (2007).

Article  PubMed  Google Scholar 

Cheong, C. et al. Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas. Cell 143, 416–429 (2010).

Article  CAS  PubMed  PubMed Central