Swanton, C. et al. Embracing cancer complexity: hallmarks of systemic disease. Cell 187, 1589–1616 (2024).
Article CAS PubMed PubMed Central Google Scholar
de Visser, K. E. & Joyce, J. A. The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth. Cancer Cell 41, 374–403 (2023).
Kroemer, G., McQuade, J. L., Merad, M., Andre, F. & Zitvogel, L. Bodywide ecological interventions on cancer. Nat. Med. 29, 59–74 (2023).
Article CAS PubMed Google Scholar
Greaves, M. & Maley, C. C. Clonal evolution in cancer. Nature 481, 306–313 (2012).
Article CAS PubMed PubMed Central Google Scholar
Lavery, J. A. et al. Association of exercise with pan-cancer incidence and overall survival. Cancer Cell https://doi.org/10.1016/j.ccell.2023.12.007 (2023).
Moore, S. C. et al. Association of leisure-time physical activity with risk of 26 types of cancer in 1.44 million adults. JAMA Intern. Med. 176, 816–825 (2016).
Article PubMed PubMed Central Google Scholar
Caspersen, C. J., Powell, K. E. & Christenson, G. M. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep. 100, 126–131 (1985).
CAS PubMed PubMed Central Google Scholar
Sasso, J. P. et al. A framework for prescription in exercise-oncology research. J. Cachexia Sarcopenia Muscle 6, 115–124 (2015).
Article PubMed PubMed Central Google Scholar
Torborg, S. R., Li, Z., Chan, J. E. & Tammela, T. Cellular and molecular mechanisms of plasticity in cancer. Trends Cancer 8, 735–746 (2022).
Article CAS PubMed PubMed Central Google Scholar
Batlle, E. & Clevers, H. Cancer stem cells revisited. Nat. Med. 23, 1124–1134 (2017).
Article CAS PubMed Google Scholar
Fiore, V. F., Almagro, J. & Fuchs, E. Shaping epithelial tissues by stem cell mechanics in development and cancer. Nat. Rev. Mol. Cell Biol. https://doi.org/10.1038/s41580-024-00821-0 (2025).
Article PubMed PubMed Central Google Scholar
Hicks, M. R. & Pyle, A. D. The emergence of the stem cell niche. Trends Cell Biol. 33, 112–123 (2023).
Morrison, S. J. & Spradling, A. C. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 132, 598–611 (2008).
Article CAS PubMed PubMed Central Google Scholar
Rando, T. A., Brunet, A. & Goodell, M. A. Hallmarks of stem cell aging. Cell Stem Cell 32, 1038–1054 (2025).
Article CAS PubMed PubMed Central Google Scholar
Mihaylova, M. M., Sabatini, D. M. & Yilmaz, ÖH. Dietary and metabolic control of stem cell function in physiology and cancer. Cell Stem Cell 14, 292–305 (2014).
Article CAS PubMed PubMed Central Google Scholar
Tomasetti, C., Li, L. & Vogelstein, B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science 355, 1330–1334 (2017).
Article CAS PubMed PubMed Central Google Scholar
Leja, M. J., Shah, D. J. & Reardon, M. J. Primary cardiac tumors. Tex. Heart Inst. J. 38, 261–262 (2011).
PubMed PubMed Central Google Scholar
Alcantara Llaguno, S. et al. Cell-of-origin susceptibility to glioblastoma formation declines with neural lineage restriction. Nat. Neurosci. 22, 545–555 (2019).
Article PubMed PubMed Central Google Scholar
Baggiolini, A. et al. Developmental chromatin programs determine oncogenic competence in melanoma. Science 373, eabc1048 (2021).
Article CAS PubMed PubMed Central Google Scholar
Goodell, M. A. & Rando, T. A. Stem cells and healthy aging. Science 350, 1199–1204 (2015).
Article CAS PubMed Google Scholar
Blokzijl, F. et al. Tissue-specific mutation accumulation in human adult stem cells during life. Nature 538, 260–264 (2016).
Article CAS PubMed PubMed Central Google Scholar
Zhuang, X. et al. Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis. Nature 637, 184–194 (2025).
Article CAS PubMed Google Scholar
Sanft, T. et al. NCCN guidelines(R) insights: survivorship, version 2.2024. J. Natl Compr. Canc Netw. 22, 648–658 (2024).
Ligibel, J. A. et al. Exercise, diet, and weight management during cancer treatment: ASCO guideline. J. Clin. Oncol. 40, 2491–2507 (2022).
Rock, C. L. et al. American Cancer Society nutrition and physical activity guideline for cancer survivors. CA Cancer J. Clin. 72, 230–262 (2022).
Cormie, P. et al. Clinical oncology society of Australia position statement on exercise in cancer care. Med. J. Aust. 209, 184–187 (2018).
Friedenreich, C. M., Stone, C. R., Cheung, W. Y. & Hayes, S. C. Physical activity and mortality in cancer survivors: a systematic review and meta-analysis. JNCI Cancer Spectr. 4, pkz080 (2020).
Lavery, J. A. et al. Pan-cancer analysis of postdiagnosis exercise and mortality. J. Clin. Oncol. https://doi.org/10.1200/JCO.23.00058 (2023).
Article PubMed PubMed Central Google Scholar
Courneya, K. S. et al. Structured exercise after adjuvant chemotherapy for colon cancer. N. Engl. J. Med. 393, 13–25 (2025).
Article CAS PubMed Google Scholar
Jones, L. W. Exercise and cancer outcomes: what do we know and where next? J. Sport Health Sci. 14, 101068 (2025).
Article PubMed PubMed Central Google Scholar
Koelwyn, G. J., Quail, D. F., Zhang, X., White, R. M. & Jones, L. W. Exercise-dependent regulation of the tumour microenvironment. Nat. Rev. Cancer 17, 620–632 (2017).
Nash, D. M., Terry, L. V. & Febbraio, M. A. Exercising through cancer: physical activity as medicine for cancer care. Cancer Cell 43, 2175–2180 (2025).
Article CAS PubMed Google Scholar
Steensberg, A. et al. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J. Physiol. 529, 237–242 (2000).
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