Amidfar M, Askari G, Kim YK. Association of metabolic dysfunction with cognitive decline and Alzheimer’s disease: a review of metabolomic evidence. Prog Neuropsychopharmacol Biol Psychiatry. 2024;128:110848.

Article  CAS  PubMed  Google Scholar 

Angelidi AM, Belanger MJ, Kokkinos A, Koliaki CC, Mantzoros CS. Novel noninvasive approaches to the treatment of obesity: from pharmacotherapy to gene therapy. Endocr Rev. 2022;43:507–57. https://doi.org/10.1210/endrev/bnab034Review.

Article  PubMed  Google Scholar 

Azzam SK, Alsafar H, Sajini AA. FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms. Int J Mol Sci. 2022. https://doi.org/10.3390/ijms23073800.

Article  PubMed  PubMed Central  Google Scholar 

Berlivet S, Scutenaire J, Deragon JM, Bousquet-Antonelli C. Readers of the m 6 A epitranscriptomic code. Biochim Et Biophys Acta Gene Regul Mech. 2019;1862:329–42.

Article  CAS  Google Scholar 

Bettcher BM, Neuhaus J, Wynn MJ, Elahi FM, Casaletto KB, Saloner R, et al. Increases in a pro-inflammatory chemokine, MCP-1, are related to decreases in memory over time. Front Aging Neurosci. 2019;10:25.

Article  Google Scholar 

Brejchova K, Radner FPW, Balas L, Paluchova V, Cajka T, Chodounska H, et al. Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides. Proc Natl Acad Sci U S A. 2021;118(2):e2020999118. https://doi.org/10.1073/pnas.2020999118.

Article  CAS  PubMed  Google Scholar 

Brito DVC, Esteves F, Rajado AT, Silva N, Andrade R, Apolónio J, et al. Assessing cognitive decline in the aging brain: lessons from rodent and human studies. Npj Aging. 2023;9:1–11. https://doi.org/10.1038/s41514-023-00120-6.

Article  Google Scholar 

Chaturvedi M, Kaczmarek L. MMP-9 inhibition: a therapeutic strategy in ischemic stroke. Mol Neurobiol. 2014;49:563–73. https://doi.org/10.1007/s12035-013-8538-z.

Article  CAS  PubMed  Google Scholar 

Chen W, Hartman R, Ayer R, Marcantonio S, Kamper J, Tang J, et al. Matrix metalloproteinases inhibition provides neuroprotection against hypoxia-ischemia in the developing brain. J Neurochem. 2009;111(3):726–36.

Article  CAS  PubMed  Google Scholar 

Chew NWS, Ng CH, Tan DJH, Kong G, Lin C, Chin YH, et al. The global burden of metabolic disease: Data from 2000 to 2019. Cell Metab. 2023;35(3):414–28.

Article  CAS  PubMed  Google Scholar 

Choi M, Kim D, Youn YJ, Ryu J, Jeong YH. Effect of obesity and high-density lipoprotein concentration on the pathological characteristics of Alzheimer’s disease in high-fat diet-fed mice. Int J Mol Sci. 2022;23(20):12296.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Almeida LGN, Thode H, Eslambolchi Y, Chopra S, Young D, Gill S, et al. Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology. Pharmacol Rev. 2022;74:712–68.

Article  PubMed  Google Scholar 

Ding C, Yimiti D, Sanada Y, Matsubara Y, Nakasa T, Matsubara K, et al. High-fat diet-induced obesity accelerates the progression of spontaneous osteoarthritis in senescence-accelerated mouse prone 8. Mod Rheumatol. 2024;34(4):831–40.

Article  PubMed  Google Scholar 

DiSabato DJ, Quan N, Godbout JP. Neuroinflammation: the devil is in the details. J Neurochem. 2016;139:136–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, Meier DT, et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med. 2011;17(11):1481–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Entezari M, Hashemi D, Taheriazam A, Zabolian A, Mohammadi S, Fakhri F, et al. AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation. Biomed Pharmacother. 2022;146:112563.

Article  CAS  PubMed  Google Scholar 

Farooqui AA, Farooqui T, Panza F, Frisardi V. Metabolic syndrome as a risk factor for neurological disorders. Cell Mol Life Sci. 2012;69:741–62.

Article  CAS  PubMed  Google Scholar 

Febbraio MA, Hiscock N, Sacchetti M, Fischer CP, Pedersen BK. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes. 2004;53(7):1643–8.

Article  CAS  PubMed  Google Scholar 

Feng B, Zheng J, Cai Y, Han Y, Han Y, Wu J, et al. An epigenetic manifestation of Alzheimer’s disease: DNA methylation. Actas Espanolas De Psiquiatria. 2024;52:365–74. https://doi.org/10.62641/aep.v52i3.1595.

Article  PubMed  PubMed Central  Google Scholar 

Gao Z, Zha X, Li M, Xia X, Wang S. Insights into the m6A demethylases FTO and ALKBH5: structural, biological function, and inhibitor development. Cell Biosci. 2024;14:108.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011;11:607–10.

Article  CAS  PubMed  Google Scholar 

Griñán-Ferré C, Corpas R, Puigoriol-Illamola D, Palomera-Ávalos V, Sanfeliu C, Pallàs M. Understanding epigenetics in the neurodegeneration of Alzheimer’s disease: SAMP8 mouse model. J Alzheimer’s Dis. 2018;62:943–63.

Article  Google Scholar 

Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, et al. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia. Cancer Cell. 2019;35(4):677–91. https://doi.org/10.1016/j.ccell.2019.03.006.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang C, Chen W, Wang X. Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases. Genes Dis. 2023a;10:2351–65.

Article  CAS  PubMed  Google Scholar 

Huang Y, Xia W, Dong Z, Yang CG. Chemical inhibitors targeting the oncogenic m6A modifying proteins. Acc Chem Res. 2023b;56(21):3010–22.

Article  CAS  PubMed  Google Scholar 

Huang WM, Li ZX, Wu YH, Shi ZL, Mi JL, Hu K, et al. m6A demethylase FTO renders radioresistance of nasopharyngeal carcinoma via promoting OTUB1-mediated anti-ferroptosis. Transl Oncol. 2023c;27:101576.

Article  CAS  PubMed  Google Scholar 

Jiang L, Liang R, Luo Q, Chen Z, Song G. Targeting FTO suppresses hepatocellular carcinoma by inhibiting ERBB3 and TUBB4A expression. Biochem Pharmacol. 2024;226:116375.

Article  CAS  PubMed  Google Scholar 

Justo AFO, Suemoto CK. The modulation of neuroinflammation by inducible nitric oxide synthase. J Cell Commun Signal. 2022;16(2):155–8. https://doi.org/10.1007/s12079-021-00663-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kan L, Ott S, Joseph B, Park ES, Dai W, Kleiner RE, et al. A neural m6A/Ythdf pathway is required for learning and memory in Drosophila. Nat Commun. 2021;12(1):1–18. https://doi.org/10.1038/s41467-021-21537-1.

Article  CAS  Google Scholar 

Kok HJ, Barton ER. Actions and interactions of IGF-I and MMPs during muscle regeneration. Semin Cell Dev Biol. 2021;119:11–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kummer KK, Zeidler M, Kalpachidou T, Kress M. Role of IL-6 in the regulation of neuronal development, survival and function. Cytokine. 2021;144:155582.