Hutchings, M. I., Truman, A. W. & Wilkinson, B. Antibiotics: past, present and future. Curr. Opin. Microbiology 51, 72–80 (2019).
Mancuso, G., Midiri, A., Gerace, E. & Biondo, C. Bacterial antibiotic resistance: the most critical pathogens. Pathogens https://doi.org/10.3390/pathogens10101310 (2021).
Naghavi, M. et al. Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050. Lancet 404, 1199–1226 (2024).
Blair, J. M. A., Webber, M. A., Baylay, A. J., Ogbolu, D. O. & Piddock, L. J. V. Molecular mechanisms of antibiotic resistance. Nat. Rev. Microbiol. 13, 42–51 (2015).
Article CAS PubMed Google Scholar
Bhargava, P. & Collins, J. J. Boosting bacterial metabolism to combat antibiotic resistance. Cell Metab. 21, 154–155 (2015).
Article CAS PubMed Google Scholar
Liu, Y., Yang, K., Zhang, H., Jia, Y. & Wang, Z. Combating antibiotic tolerance through activating bacterial metabolism. Front. Microbiol. 11, 577564 (2020).
Article PubMed PubMed Central Google Scholar
Kitzenberg, D. A. et al. Adenosine awakens metabolism to enhance growth-independent killing of tolerant and persister bacteria across multiple classes of antibiotics. mBio 13, e00480–e00522 (2022).
Article PubMed PubMed Central Google Scholar
Stokes, J. M., Lopatkin, A. J., Lobritz, M. A. & Collins, J. J. Bacterial metabolism and antibiotic efficacy. Cell Metab. 30, 251–259 (2019).
Article CAS PubMed PubMed Central Google Scholar
Hooper, D. C. & Jacoby, G. A. Topoisomerase inhibitors: fluoroquinolone mechanisms of action and resistance. Cold Spring Harb. Perspect. Med. 6, a025320 (2016).
Article PubMed PubMed Central Google Scholar
Gutierrez, A. et al. Understanding and sensitizing density-dependent persistence to quinolone antibiotics. Mol. Cell 68, 1147–1154.e3 (2017).
Article CAS PubMed Google Scholar
Krause, K. M., Serio, A. W., Kane, T. R. & Connolly, L. E. Aminoglycosides: an overview. Cold Spring Harb. Perspect. Med. 6, a027029 (2016).
Article PubMed PubMed Central Google Scholar
Wohlgemuth, I. et al. Translation error clusters induced by aminoglycoside antibiotics. Nat. Commun. 12, 1830 (2021).
Article CAS PubMed PubMed Central Google Scholar
Cabral, D. J. et al. Microbial metabolism modulates antibiotic susceptibility within the murine gut microbiome. Cell Metab. 30, 800–823 (2019).
Article CAS PubMed PubMed Central Google Scholar
Mohiuddin, S. G., Ngo, H. & Orman, M. A. Unveiling the critical roles of cellular metabolism suppression in antibiotic tolerance. npj Antimicrob. Resist. 2, 1–10 (2024).
Reese, A. T. et al. Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut. eLife 7, e35987 (2018).
Article PubMed PubMed Central Google Scholar
VanHook, A. M. Antibiotics directly affect host cell metabolism. Sci. Signal. 11, eaas9172 (2018).
Lopatkin, A. J. et al. Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate. Nat. Microbiol. 4, 2109–2117 (2019).
Article PubMed PubMed Central Google Scholar
Baquero, F. & Levin, B. R. Proximate and ultimate causes of the bactericidal action of antibiotics. Nat. Rev. Microbiol. 19, 123–132 (2021).
Article CAS PubMed Google Scholar
Cho, H., Uehara, T. & Bernhardt, T. G. β-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery. Cell 159, 1300–1311 (2014).
Article CAS PubMed PubMed Central Google Scholar
Dawan, J. & Ahn, J. Bacterial stress responses as potential targets in overcoming antibiotic resistance. Microorganisms 10, 1385 (2022).
Article CAS PubMed PubMed Central Google Scholar
Qi, W. et al. The effect of the stringent response and oxidative stress response on fitness costs of de novo acquisition of antibiotic resistance. Int. J. Mol. Sci. 25, 2582 (2024).
Article CAS PubMed PubMed Central Google Scholar
Kawai, Y. et al. On the mechanisms of lysis triggered by perturbations of bacterial cell wall biosynthesis. Nat. Commun. 14, 4123 (2023).
Article CAS PubMed PubMed Central Google Scholar
Dwyer, D. J. et al. Antibiotics induce redox-related physiological alterations as part of their lethality. Proc. Natl Acad. Sci. USA 111, E2100–E2109 (2014).
Article CAS PubMed PubMed Central Google Scholar
Kohanski, M. A., Dwyer, D. J., Hayete, B., Lawrence, C. A. & Collins, J. J. A common mechanism of cellular death induced by bactericidal antibiotics. Cell 130, 797–810 (2007).
Article CAS PubMed Google Scholar
Liu, Y. et al. Inhibitors of reactive oxygen species accumulation delay and/or reduce the lethality of several antistaphylococcal agents. Antimicrob. Agents Chemother. 56, 6048–6050 (2012).
Article CAS PubMed PubMed Central Google Scholar
Rowan, A. D., Cabral, D. J. & Belenky, P. Bactericidal antibiotics induce programmed metabolic toxicity. Microb. Cell 3, 178–180 (2015).
Qi, W., Jonker, M. J., de Leeuw, W., Brul, S. & Ter Kuile, B. H. Reactive oxygen species accelerate de novo acquisition of antibiotic resistance in E. coli. iScience 26, 108373 (2023).
Article CAS PubMed PubMed Central Google Scholar
Kalghatgi, S. et al. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in mammalian cells. Sci. Transl. Med. 5, 192ra85 (2013).
Article PubMed PubMed Central Google Scholar
Zeng, S. et al. Isoniazid bactericidal activity involves electron transport chain perturbation. Antimicrob. Agents Chemother. 63, e01841–e01918 (2019).
Article CAS PubMed PubMed Central Google Scholar
Lobritz, M. A. et al. Antibiotic efficacy is linked to bacterial cellular respiration. Proc. Natl Acad. Sci. USA 112, 8173–8180 (2015).
Article CAS PubMed PubMed Central Google Scholar
Xu, Z. et al. Droplet-based high-throughput single microbe RNA sequencing by smRandom-seq. Nat. Commun. 14, 5130 (2023).
Article CAS PubMed PubMed Central Google Scholar
Lopatkin, A. J. et al. Clinically relevant mutations in core metabolic genes confer antibiotic resistance. Science 371, eaba0862 (2021).
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