Alterations in the lipid profile of critically ill children in relation to outcome

Teblick A, Gunst J, Langouche L, Van den Berghe G. Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research. Clin Sci (Lond). 2022;136(11):861–78.

Article  PubMed  CAS  Google Scholar 

Lauwers C, De Bruyn L, Langouche L. Impact of critical illness on cholesterol and fatty acids: insights into pathophysiology and therapeutic targets. Intensive Care Med Exp. 2023;11(1):84.

Article  PubMed  PubMed Central  Google Scholar 

Chiarla C, Giovannini I, Giuliante F, Zadak Z, Vellone M, Ardito F, Clemente G, Murazio M, Nuzzo G. Severe hypocholesterolemia in surgical patients, sepsis, and critical illness. J Crit Care. 2010;25(2):361–7.

Article  Google Scholar 

Mesotten D, Swinnen JV, Vanderhoydonc F, Wouters PJ, Van den Berghe G. Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab. 2004;89(1):219–26.

Article  PubMed  CAS  Google Scholar 

Tanaka S, Labreuche J, Drumez E, Harrois A, Hamada S, Vigue B, et al. Low HDL levels in sepsis versus trauma patients in intensive care unit. Ann Intensive Care. 2017;7(1):60.

Article  PubMed  PubMed Central  Google Scholar 

Hofmaenner DA, Arina P, Kleyman A, Page Black L, Salomao R, Tanaka S, et al. Association between Hypocholesterolemia and mortality in critically Ill patients with sepsis: a systematic review and meta-analysis. Crit Care Explor. 2023;5(2):e0860.

Article  PubMed  PubMed Central  Google Scholar 

Dunham CM, Fealk MH, Sever WE 3rd. Following severe injury, hypocholesterolemia improves with convalescence but persists with organ failure or onset of infection. Crit Care. 2003;7(6):R145–53.

Article  PubMed  PubMed Central  Google Scholar 

Wu J, Su C, Jiang J, Mao Y. The potential role of serum lipoprotein in children with sepsis. Medicine (Baltimore). 2023;102(48):e36311.

Article  PubMed  CAS  Google Scholar 

Bermudes ACG, de Carvalho WB, Zamberlan P, Muramoto G, Maranhao RC, Delgado AF. Changes in lipid metabolism in pediatric patients with severe sepsis and septic shock. Nutrition. 2018;47:104–9.

Article  PubMed  CAS  Google Scholar 

Vermont CL, den Brinker M, Kakeci N, de Kleijn ED, de Rijke YB, Joosten KF, et al. Serum lipids and disease severity in children with severe meningococcal sepsis. Crit Care Med. 2005;33(7):1610–5.

Article  PubMed  CAS  Google Scholar 

Hulst JM, van Goudoever JB, Zimmermann LJ, Tibboel D, Joosten KF. The role of initial monitoring of routine biochemical nutritional markers in critically ill children. J Nutr Biochem. 2006;17(1):57–62.

Article  PubMed  CAS  Google Scholar 

Fivez T, Kerklaan D, Mesotten D, Verbruggen S, Wouters PJ, Vanhorebeek I, et al. Early versus late parenteral nutrition in critically Ill children. N Engl J Med. 2016;374(12):1111–22.

Article  PubMed  CAS  Google Scholar 

De Bruyn A, Gunst J, Goossens C, Vander Perre S, Guerra GG, Verbruggen S, et al. Effect of withholding early parenteral nutrition in PICU on ketogenesis as potential mediator of its outcome benefit. Crit Care. 2020;24(1):536.

Article  PubMed  PubMed Central  Google Scholar 

Dathan-Stumpf A, Vogel M, Hiemisch A, Thiery J, Burkhardt R, Kratzsch J, et al. Pediatric reference data of serum lipids and prevalence of dyslipidemia: results from a population-based cohort in Germany. Clin Biochem. 2016;49(10–11):740–9.

Article  PubMed  CAS  Google Scholar 

Bonville DA, Parker TS, Levine DM, Gordon BR, Hydo LJ, Eachempati SR, et al. The relationships of hypocholesterolemia to cytokine concentrations and mortality in critically ill patients with systemic inflammatory response syndrome. Surg Infect (Larchmt). 2004;5(1):39–49.

Article  PubMed  Google Scholar 

Nielsen TRH, Lausten-Thomsen U, Fonvig CE, Bojsoe C, Pedersen L, Bratholm PS, et al. Dyslipidemia and reference values for fasting plasma lipid concentrations in Danish/North-European white children and adolescents. BMC Pediatr. 2017;17(1):116.

Article  PubMed  PubMed Central  Google Scholar 

De Bruyn L, Teblick A, Van Oudenhove T, Vander Perre S, Derese I, Pauwels L, et al. Glucocorticoid treatment increases cholesterol availability during critical illness: effect on adrenal and muscle function. Crit Care. 2024;28(1):295.

Article  PubMed  PubMed Central  Google Scholar 

van Leeuwen HJ, Heezius EC, Dallinga GM, van Strijp JA, Verhoef J, van Kessel KP. Lipoprotein metabolism in patients with severe sepsis. Crit Care Med. 2003;31(5):1359–66.

Article  PubMed  Google Scholar 

Chien JY, Jerng JS, Yu CJ, Yang PC. Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis. Crit Care Med. 2005;33(8):1688–93.

Article  PubMed  CAS  Google Scholar 

Levels JH, Abraham PR, van den Ende A, van Deventer SJ. Distribution and kinetics of lipoprotein-bound endotoxin. Infect Immun. 2001;69(5):2821–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Parker TS, Levine DM, Chang JC, Laxer J, Coffin CC, Rubin AL. Reconstituted high-density lipoprotein neutralizes gram-negative bacterial lipopolysaccharides in human whole blood. Infect Immun. 1995;63(1):253–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Guirgis FW, Black LP, Henson M, Bertrand A, DeVos E, Ferreira J, et al. The lipid intensive drug therapy for sepsis phase II pilot clinical trial. Crit Care Med. 2024;52(8):1183–93.

Article  PubMed  CAS  Google Scholar 

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